Results 71 to 80 of about 12,255 (190)
Electronic Journal of Statistics, 2017 Isotonic regression offers a flexible modeling approach under monotonicity assumptions, which are natural in many applications. Despite this attractive setting and extensive theoretical research, isotonic regression has enjoyed limited interest in practical modeling primarily due to its tendency to suffer significant overfitting, even in moderate ...
Luss, Ronny, Rosset, Saharon
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A non-parametric framework for estimating threshold limit values
BMC Medical Research Methodology, 2005 Background To estimate a threshold limit value for a compound known to have harmful health effects, an 'elbow' threshold model is usually applied. We are interested on non-parametric flexible alternatives.
Ulm Kurt, Salanti Georgia
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Diabetic Medicine, EarlyView.This systematic review of 36 studies comparing machine learning with traditional statistical models for predicting diabetes‐related complications found modest discrimination gains with ensemble approaches, particularly random forest and gradient boosting.
Bismah Ghafoor +3 more
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The FEBS Journal, EarlyView.Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang +5 more
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International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction The Atellica HEMA 580 is a novel haematology analyser providing eight‐part leukocyte differential and optical platelet (PLT) counting. We compared its analytical and clinical performance with that of the ADVIA 2120i. Methods A total of 796 residual whole blood specimens were analysed.
Hyeongyu Lee +3 more
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Weighted L∞ isotonic regression
Journal of Computer and System Sciences, 2018 Abstract Algorithms are given for determining weighted L ∞ isotonic regressions satisfying order constraints given by a directed acyclic graph with n vertices and m edges. An Θ ( m log n ) algorithm is given, but it uses parametric search, so a practical approach is introduced, based on calculating prefix solutions.
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Journal of Fish Biology, EarlyView.Abstract Fish must manage the competing demands of ion balance and gas exchange across the gills – a physiological tension known as the osmorespiratory compromise. In dynamic estuarine environments, the osmorespiratory compromise may be exacerbated by variable salinity and periods of hypoxia that demand high respiratory work.
Timothy D. Clark +4 more
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Application of isotonic regression in estimating EDg and its 95% confidence interval by bootstrap method for a biased coin up-and-down sequential dose-finding design. [PDF]
Indian J Anaesth, 2023 Hemraj C +3 more
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Modified isotonic regression based phase I/II clinical trial design identifying optimal biological dose. [PDF]
Contemp Clin Trials, 2023 Qiu Y +5 more
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Engineered surface strategies to manage dental implant‐related infections
Periodontology 2000, EarlyView.Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza +7 more
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