Results 71 to 80 of about 12,339 (203)

Generalized Isotonic Regression [PDF]

Journal of Computational and Graphical Statistics, 2014
Minor changes. Final version.
Luss, Ronny, Rosset, Saharon
openaire   +2 more sources

Topology‐Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates

Small, EarlyView.
Electrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Julio Fernández‐Fernández, Vicente Domínguez‐Arca, Raúl Escribano, Sheila Lorenzo, Sergio Ferrero, Sergio Acosta, José Carlos Rodríguez‐Cabello   +6 more
wiley   +1 more source

Effective dose of intranasal remimazolam for preoperative sedation in preschool children: a dose-finding study using Dixon’s up-and-down method

Frontiers in Pharmacology
Background:Most preschool children are distressed during anesthesia induction. While current pharmacological methods are useful, there is a need for further optimization to an “ideal” standard.
Ming-Jie Ni, Yu-Ting Jin, Qian-Lin Wu, Ning Zhang, Jia-He Tian, Jun Li, Kai-Ming Yuan   +6 more
doaj   +1 more source

Comparative predictive accuracy of machine learning versus traditional statistical methods for diabetes‐related complications: A systematic review and analysis

Diabetic Medicine, EarlyView.
This systematic review of 36 studies comparing machine learning with traditional statistical models for predicting diabetes‐related complications found modest discrimination gains with ensemble approaches, particularly random forest and gradient boosting.
Bismah Ghafoor, Francesco Zaccardi, Kamlesh Khunti, Sharmin Shabnam   +3 more
wiley   +1 more source

Weighted L∞ isotonic regression

Journal of Computer and System Sciences, 2018
Abstract Algorithms are given for determining weighted L ∞ isotonic regressions satisfying order constraints given by a directed acyclic graph with n vertices and m edges. An Θ ( m log ⁡ n ) algorithm is given, but it uses parametric search, so a practical approach is introduced, based on calculating prefix solutions.
openaire   +2 more sources

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Bounded isotonic regression

Electronic Journal of Statistics, 2017
Isotonic regression offers a flexible modeling approach under monotonicity assumptions, which are natural in many applications. Despite this attractive setting and extensive theoretical research, isotonic regression has enjoyed limited interest in practical modeling primarily due to its tendency to suffer significant overfitting, even in moderate ...
Luss, Ronny, Rosset, Saharon
openaire   +2 more sources

A non-parametric framework for estimating threshold limit values

BMC Medical Research Methodology, 2005
Background To estimate a threshold limit value for a compound known to have harmful health effects, an 'elbow' threshold model is usually applied. We are interested on non-parametric flexible alternatives.
Ulm Kurt, Salanti Georgia
doaj   +1 more source

Myo1g Mediates NKR‐P1C Expression in Primary Mouse NK Cells and Participates in Cytotoxicity

Immunology, EarlyView.
In this study we analysed the participation of Myosin 1g in the development and functions of murine natural killer (NK) cells; we found that Myosin 1g is expressed in murine‐activated primary NK cells from the spleen. Additionally, in the absence of Myosin 1g, correlates with a reduced expression of NKR‐P1C but not of CD49b or NKp46.
Héctor Romero‐Ramírez, Vania Aminta Zuleica López‐Esparza, Mariana Flores‐Castelán, Leopoldo Santos‐Argumedo   +3 more
wiley   +1 more source

Clinical use of sodium bicarbonate in small animals: indications, electrolyte changes and survival outcome

Journal of Small Animal Practice, EarlyView.
Objectives The objective of the study was to describe the use of sodium bicarbonate in dogs and cats. Materials and Methods Retrospective descriptive study of animals administered sodium bicarbonate from 2019 to 2023 in a university teaching hospital.
L. Hoover, M. A. Oyama, E. L. Reineke
wiley   +1 more source