Results 171 to 180 of about 17,156 (211)
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2008
Isoxazoles, benzisoxazoles, isoxazolines, and isoxazolidines are classes of heterocyclic compounds having a remarkable number of applications and are very versatile building blocks in organic synthesis. The major developments on the chemistry of these heterocycles reported in the literature from 1996 to 2006 are reviewed.
GIOMI, DONATELLA +2 more
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Isoxazoles, benzisoxazoles, isoxazolines, and isoxazolidines are classes of heterocyclic compounds having a remarkable number of applications and are very versatile building blocks in organic synthesis. The major developments on the chemistry of these heterocycles reported in the literature from 1996 to 2006 are reviewed.
GIOMI, DONATELLA +2 more
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2001
Publisher Summary Natural products based on the isoxazole (1,2-oxazole) skeleton constitute a small, heterogeneous group of natural products encompassing at present more than 90 structures. This group has not traditionally been classified as a special alkaloid group and has never been reviewed as a group previously.
L, Rahbaek, C, Christophersen
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Publisher Summary Natural products based on the isoxazole (1,2-oxazole) skeleton constitute a small, heterogeneous group of natural products encompassing at present more than 90 structures. This group has not traditionally been classified as a special alkaloid group and has never been reviewed as a group previously.
L, Rahbaek, C, Christophersen
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Isoxazoles with antipicornavirus activity
Journal of Medicinal Chemistry, 1985The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected ...
G D, Diana +5 more
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2022
Isoxazoles, isoxazolines and isoxazolidines are a class of heterocyclic compounds having a remarkable number of applications and are very versatile building blocks in organic synthesis. The developments concerning the synthesis of the above monocyclic systems reported in the literature from 2007 to 2019 are reviewed.
Cordero, Franca M. +2 more
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Isoxazoles, isoxazolines and isoxazolidines are a class of heterocyclic compounds having a remarkable number of applications and are very versatile building blocks in organic synthesis. The developments concerning the synthesis of the above monocyclic systems reported in the literature from 2007 to 2019 are reviewed.
Cordero, Franca M. +2 more
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Isoxazole is a versatile five-membered heterocyclic compound that has attracted significant attention due to its diverse medicinal chemistry and material science applications. This chapter provides a comprehensive overview of synthetic methodologies for preparing isoxazole derivatives, including traditional approaches such as cyclization reactions and ...
Erum Akbar Hussain +2 more
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Erum Akbar Hussain +2 more
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Oxazolo[4,5-d]isoxazole Derivatives and 3,4-Disubstituted Isoxazoles from Isoxazol-5(4H)-ones
Synthetic Communications, 1993Abstract Synthesis for oxazolo[4,5-d]isoxazole derivatives and 3,4-disubstituted isoxazoles from isoxazol-5(4H)-ones is reported.
E.M. Beccalli, A. Marchesini, T. Pilati
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Isoxazole Ionotropic Glutamate Neurotransmitters
Current Medicinal Chemistry, 2005Analogs of the excitatory neurotransmitter glutamate are potential medicinal agents for a wide variety of neurological disorders. The isoxazole glutamate derivatives represent an important class of compounds because of their receptor specificity and binding affinity. Since the discovery of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid (
David J, Burkhart, N R, Natale
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Isoxazoles I: Protonation of Isoxazole Derivatives in Aqueous Sulfuric Acid
Journal of Pharmaceutical Sciences, 1973The protonation of 3-amino-5-methylisoxazole, 5-amino-3,4-dimethylisoxazole, sulfamethoxazole (N-sulfanilamido-5-methyl-3-isoxazole), and sulfisoxazole (N-sulfanilamido-3,4-dimethyl-5-isoxazole) in aqueous sulfuric acid was studied. The pKSH+ and log SH+/S or log SH2+2/SH+ values were determined by UV spectrophotometry.
R H, Manzo, M M, De Bertorello
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The Journal of Organic Chemistry, 2019
The first synthesis of isoxazole-4-carboxylic acid derivatives by domino isoxazole-isoxazole isomerization is reported. Fe(II)-catalyzed isomerization of 4-acyl-5-methoxy-/5-aminoisoxazoles (dioxane, 105 °C) leads to the formation of isoxazole-4-carboxylic esters and amides in good yields. 4-Formyl-5-methoxyisoxazoles give methyl oxazole-4-carboxylates
Anna V. Serebryannikova +3 more
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The first synthesis of isoxazole-4-carboxylic acid derivatives by domino isoxazole-isoxazole isomerization is reported. Fe(II)-catalyzed isomerization of 4-acyl-5-methoxy-/5-aminoisoxazoles (dioxane, 105 °C) leads to the formation of isoxazole-4-carboxylic esters and amides in good yields. 4-Formyl-5-methoxyisoxazoles give methyl oxazole-4-carboxylates
Anna V. Serebryannikova +3 more
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Trisubstituted isoxazoles from 3,4-disubstituted-(2H)-isoxazol-5-ones
Tetrahedron, 1998Abstract A new trisubstituted isoxazole synthesis, starting from 3,4-disubstituted-(2H)-isoxazol-5-ones, is ...
E.M. Beccalli, M.L. Gelmi, A. Marchesini
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