Results 1 to 10 of about 20,504 (258)

Trifluoromethylated Flavonoid-Based Isoxazoles as Antidiabetic and Anti-Obesity Agents: Synthesis, In Vitro α-Amylase Inhibitory Activity, Molecular Docking and Structure–Activity Relationship Analysis

Molecules, 2021
Diabetes mellitus is a major health problem globally. The management of carbohydrate digestion provides an alternative treatment. Flavonoids constitute the largest group of polyphenolic compounds, produced by plants widely consumed as food and/or used ...
Faisal K. Algethami, Ilyes Saidi, Hani Nasser Abdelhamid, Mohamed R. Elamin, Babiker Y. Abdulkhair, Amani Chrouda, Hichem Ben Jannet   +6 more
doaj   +2 more sources

Efficient Synthesis, Structural Characterization, Antibacterial Assessment, ADME-Tox Analysis, Molecular Docking and Molecular Dynamics Simulations of New Functionalized Isoxazoles. [PDF]

Molecules
This work describes the synthesis, characterization, and in vitro and in silico evaluation of the biological activity of new functionalized isoxazole derivatives. The structures of all new compounds were analyzed by IR and NMR spectroscopy.
Arzine A, Hadni H, Boujdi K, Chebbac K, Barghady N, Rhazi Y, Chalkha M, Nakkabi A, Chkirate K, Mague JT, Kawsar SMA, Al Houari G, M Alanazi M, El Yazidi M.   +13 more
europepmc   +2 more sources

Copper(II)-Photocatalyzed Radical Anellation of Nitroalkanes with Alkenes or Alkynes for the Synthesis of Isoxazolines and Isoxazoles. [PDF]

Angew Chem Int Ed Engl
We present a Cu(II)‐photocatalyzed method that employs commercially available nitroalkanes for the synthesis of isoxazolines and isoxazoles from alkenes and alkynes, respectively. Detailed mechanistic investigations revealed that the broad substrate scope, encompassing both activated and unactivated alkenes and alkynes, is attributable to a radical ...
Sardana S, Pattanaik A, Rehbein J, Reiser O.   +3 more
europepmc   +2 more sources

Mechanochemical Strategies Applied to the Late-Stage Modifications of Pharmaceutically Active Compounds. [PDF]

Angew Chem Int Ed Engl
This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Templ J, Borchardt L.
europepmc   +2 more sources

Synthesis of 2H-azirine-2,2-dicarboxylic acids and their derivatives [PDF]

Beilstein Journal of Organic Chemistry
Methods for the preparation of 3-aryl-2H-azirine-2,2-dicarboxylic acids and their amides, esters, and azides by FeCl2-catalyzed isomerization of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides into 3-aryl-2H-azirine-2,2-dicarbonyl dichlorides followed by ...
Anastasiya V. Agafonova, Mikhail S. Novikov, Alexander F. Khlebnikov   +2 more
doaj   +2 more sources

Azirinyl-Substituted Nitrile Oxides: Generation and Use in the Synthesis of Isoxazole Containing Heterocyclic Hybrids [PDF]

Molecules
The procedure for the generation of azirinyl-substituted nitrile oxides by the reaction of 2-(diazoacetyl)-2H-azirines with tert-butyl nitrite while preserving the azirine ring has been developed.
Alexander S. Dudik, Timur O. Zanakhov, Ekaterina E. Galenko, Mikhail S. Novikov, Alexander F. Khlebnikov   +4 more
doaj   +2 more sources

Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity [PDF]

Molecules
Easy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl)isoxazole derivatives via 1,3-dipolar cycloaddition with terminal alkynes, 1,1 ...
Ekaterina E. Galenko, Mikhail S. Novikov, Alexander S. Bunev, Alexander F. Khlebnikov   +3 more
doaj   +2 more sources

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Pharmaceuticals, 2023
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates.
Xiyue Wang, Qingyun Hu, Hui Tang, Xinhui Pan   +3 more
doaj   +1 more source

Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides

Beilstein Journal of Organic Chemistry, 2022
Herein we report a method for the synthesis of 3,4,5-trisubstituted isoxazoles in water under mild basic conditions at room temperature via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides.
Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le   +3 more
doaj   +1 more source

Design, Synthesis, and Biological Assessment of Novel Vanillin-Isoxazole Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptor

Chemistry Proceedings, 2023
The homomeric α7 nicotinic acetylcholine receptor (α7 nAChR) is a cation-permeable pentameric ligand-gated channel present in the nervous system and non-neuronal cells.
Santiago Stabile, Juan Facundo Chrestia, Gabriel Radivoy, Cecilia Bouzat   +3 more
doaj   +1 more source