Results 41 to 50 of about 19,238 (306)
Electrochemical Synthesis of Isoxazoles and Isoxazolines via Anodic Oxidation of Oximes
ChemElectroChem, 2023 Isoxazol(in)es are widely featured structural motifs in natural products, agrochemicals, and pharmaceuticals. The first intermolecular approach for a direct electrochemical synthesis from readily available aldoximes is reported.
Silja Hofmann +4 more
doaj +1 more source
Molecules, 2022 Amides, anhydrides, esters, and thioesters of 2H-azirine-2-carboxylic acids were prepared by a rapid procedure at room temperature involving FeCl2-catalyzed isomerization of 5-chloroisoxazoles to 2H-azirine-2-carbonyl chlorides, followed by reaction with
Anastasiya V. Agafonova +2 more
doaj +1 more source
Development of the novel isoxazolo[3,4-d]pyridazinone scaffold, which positively modulates the metabotropic glutamate receptor subtypes 2 and 4 [PDF]
, 2022 The seven transmembrane (7TM) superfamily, also known as G-protein coupled receptors (GPCR), are one of the largest superfamilies in the human genome.
Gates, Christina Ann
core +1 more source
Beilstein Journal of Organic Chemistry, 2011 The first photocycloadditions of aromatic and aliphatic aldehydes to methylated isoxazoles are reported. The reactions lead solely to the exo-adducts with high regio- and diastereoselectivities. Ring methylation of the isoxazole substrates is crucial for
Axel G. Griesbeck +3 more
doaj +1 more source
Organics, 2021 Conjugated azapolyenes (azabuta-1,3-dienes, aza-/diaza-/oxaza-/oxadiazahexa-1,3,5-trienes) are highly reactive in electrocyclization reactions, which makes them convenient precursors for the synthesis of a wide range of four-, five-, and six-membered ...
Nikolai V. Rostovskii +2 more
doaj +1 more source
Chemical Science, 2018 Gold-catalysed [4+3]- and [4+2]-annulations of 3-substituted 3-en-1-ynamides with isoxazoles were achieved with Au(i) and Au(i)/Zn(ii) catalysts respectively.
Sovan Sundar Giri, Rai‐Shung Liu
semanticscholar +1 more source
Target Agnostic Photoaffinity Labelling by Sulfonylhydrazones. [PDF]
Angew Chem Int Ed EnglSulfonyl hydrazones were identified as new photo‐crosslinkers exploiting their base catalyzed low‐energy photoactivation that leads to reactive carbenes. The amino acid promiscuity, their usefulness in proteomics application and the range of labelled targets including enzymes, a PPI target and a transcription factor suggests that sulfonyl hydrazones ...
Garami K +9 more
europepmc +3 more sources
Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1998 The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj
Organic Letters, 2019 α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base.
Pankaj V Khairnar +7 more
semanticscholar +1 more source
Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated with an adjunctive noncompetitive AMPA‐receptor ...
Robert M. Helling +6 more
wiley +1 more source