Results 41 to 50 of about 19,561 (308)

Synthesis of Fused Isoxazoles: A Comprehensive Review

Engineering Proceedings
Pharmaceutically important isoxazoles are within the wide range of heterocycles. The isoxazole ring, being five-membered, is also found in many bioactive natural products in addition to synthetic drugs.
Niveditha N. Mallik, Chandramouli Manasa, Vrushabendra Basavanna, Dileep C. Shanthakumar, Srikantamurthy Ningaiah, Nagarakere S. Lingegowda   +5 more
doaj   +1 more source

Synthesis and Antimicrobial Activity of some Ester Functionalized Isoxazoles incorporating Anthracene Moieties via Nucleophilic Substitution Reaction

Zanco Journal of Medical Sciences, 2023
Background and objective: Five-membered heterocycle compounds having single oxygen and nitrogen atom at adjacent positions are known as isoxazoles. Isoxazole compounds have a broad range of biological activities and therapeutic value.
Sarbast M. Ahmed, Hewa Omer Ahmed, Faiq H. S. Hussain, Hayman Sardar Abdulrahman, Hemn A. Qader   +4 more
doaj  

Electrochemical Synthesis of Isoxazoles and Isoxazolines via Anodic Oxidation of Oximes

ChemElectroChem, 2023
Isoxazol(in)es are widely featured structural motifs in natural products, agrochemicals, and pharmaceuticals. The first intermolecular approach for a direct electrochemical synthesis from readily available aldoximes is reported.
Silja Hofmann, Johannes Winter, Tobias Prenzel, Dr. María deJesús Gálvez‐Vázquez, Prof. Dr. Siegfried R. Waldvogel   +4 more
doaj   +1 more source

Electrocyclizations of Conjugated Azapolyenes Produced in Reactions of Azaheterocycles with Metal Carbenes

Organics, 2021
Conjugated azapolyenes (azabuta-1,3-dienes, aza-/diaza-/oxaza-/oxadiazahexa-1,3,5-trienes) are highly reactive in electrocyclization reactions, which makes them convenient precursors for the synthesis of a wide range of four-, five-, and six-membered ...
Nikolai V. Rostovskii, Mikhail S. Novikov, Alexander F. Khlebnikov   +2 more
doaj   +1 more source

Photocycloaddition of aromatic and aliphatic aldehydes to isoxazoles: Cycloaddition reactivity and stability studies

Beilstein Journal of Organic Chemistry, 2011
The first photocycloadditions of aromatic and aliphatic aldehydes to methylated isoxazoles are reported. The reactions lead solely to the exo-adducts with high regio- and diastereoselectivities. Ring methylation of the isoxazole substrates is crucial for
Axel G. Griesbeck, Marco Franke, Jörg Neudörfl, Hidehiro Kotaka   +3 more
doaj   +1 more source

Synthesis of highly substituted allenylsilanes by alkylidenation of silylketenes [PDF]

, 2005
BACKGROUND: Allenylsilanes are useful intermediates in organic synthesis. An attractive, convergent but little used approach for their synthesis is the alkylidenation of stable silylketenes.
Ducept, P.C., Marsden, S.P.
core   +3 more sources

Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj  

Gold-catalyzed [4+3]- and [4+2]-annulations of 3-en-1-ynamides with isoxazoles via novel 6π-electrocyclizations of 3-azahepta trienyl cations

Chemical Science, 2018
Gold-catalysed [4+3]- and [4+2]-annulations of 3-substituted 3-en-1-ynamides with isoxazoles were achieved with Au(i) and Au(i)/Zn(ii) catalysts respectively.
Sovan Sundar Giri, Rai‐Shung Liu
semanticscholar   +1 more source

Catalyst Control in Positional-Selective C-H Alkenylation of Isoxazoles and a Ruthenium-Mediated Assembly of Trisubstituted Pyrroles.

Organic Letters, 2019
High levels of catalyst control are demonstrated in determining the positional selectivity in C-H alkenylation of isoxazoles. A cationic rhodium-mediated, strong-directing group promotes C( sp2)-H activation at the proximal aryl ring whereas, the ...
Pravin Kumar, M. Kapur
semanticscholar   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source