Results 41 to 50 of about 20,875 (302)

Method of identifying inhibitors of glutathione S-transferase (GST) gene expression [PDF]

open access: yes, 1999
Complementary DNA and genomic clones for three variants of GST-.pi. are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer.
Akande, Olanike   +6 more
core   +1 more source

A low-toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures [PDF]

open access: yes, 2004
We describe an inexpensive, low-toxicity and high-yielding method for the production of pure lanosterol and dihydrolanosterol from the commercially available mixture.
Kavtaradze, Levan K.   +2 more
core   +2 more sources

Various Synthetic Pathways for the Synthesis of 3,4-Disubstituted Isoxazole by One Pot Multicomponent Reaction

open access: yesOrbital: The Electronic Journal of Chemistry, 2020
Isoxazole is a five membered heterocyclic compound which is an azole with an oxygen atom next to nitrogen. The substituted isoxazole derivatives show various biological activities like antimicrobial, antiviral, anti-inflammatory, antioxidant, anticancer ...
Parul Setia, Ruchi Bharti, Renu Sharma
doaj   +3 more sources

Synthesis of Fused Isoxazoles: A Comprehensive Review

open access: yesEngineering Proceedings
Pharmaceutically important isoxazoles are within the wide range of heterocycles. The isoxazole ring, being five-membered, is also found in many bioactive natural products in addition to synthetic drugs.
Niveditha N. Mallik   +5 more
doaj   +1 more source

Isoxazolium N-ylides and 1-oxa-5-azahexa-1,3,5-trienes on the way from isoxazoles to 2H-1,3-oxazines

open access: yesBeilstein Journal of Organic Chemistry, 2014
Theoretical and experimental studies of the reaction of isoxazoles with diazo compounds show that the formation of 2H-1,3-oxazines proceeds via the formation of (3Z)-1-oxa-5-azahexa-1,3,5-trienes which undergo a 6π-cyclization.
Alexander F. Khlebnikov   +6 more
doaj   +1 more source

Novel Sulfonium Reagents for the Modular Synthesis of Spiro[2.3]Hexanes and Heteroatom‐Containing Analogues: Synthesis, Application, and Evaluation as Bioisosteres

open access: yesAngewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Strained spirocyclic spiro[2.3]hexane and its heteroatom‐containing derivatives, including previously underrepresented 5‐oxa‐1‐azaspiro[2.3]hexanes and 1,5‐diazaspiro[2.3]hexanes, were synthesized via a modular approach of insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into alkenes, carbonyls and imines.
Philipp Natho   +10 more
wiley   +2 more sources

Recent advances in metal catalyzed or mediated cyclization/functionalization of alkynes to construct isoxazoles

open access: yes, 2020
Isoxazoles and their derivatives represent privileged heteroaromatic motifs, which exhibit remarkable biological and pharmaceutical activities. Notably, metal catalyzed or mediated cyclization/functionalization of alkynes such as alkynone oxime ethers ...
Jianxiao Li   +3 more
semanticscholar   +1 more source

Complexation between oleanolic and maslinic acids with native and modified cyclodextrins [PDF]

open access: yes, 2018
Oleanolic (OA) and maslinic (MA) acids are two natural triterpenoids with a wide range of beneficial effects for human health. However, their low solubility and permeability make their application in the food or industry difficult. The complexation of OA
López Miranda, Santiago
core   +2 more sources

Mechanistic Insights Into Photocatalytic Materials for Toxic Pollutants: Environmental Remediation of Personal Care Products

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Photocatalytic materials have emerged as promising solutions for environmental applications due to their ability to degrade organic pollutants under sunlight or artificial light. In this review, recent progress on the photocatalytic materials used for the degradation of pharmaceutical personal care products (PPCPs) in environmental ...
Urvashi Sen   +5 more
wiley   +1 more source

Electrochemical Synthesis of Isoxazoles and Isoxazolines via Anodic Oxidation of Oximes

open access: yesChemElectroChem, 2023
Isoxazol(in)es are widely featured structural motifs in natural products, agrochemicals, and pharmaceuticals. The first intermolecular approach for a direct electrochemical synthesis from readily available aldoximes is reported.
Silja Hofmann   +4 more
doaj   +1 more source

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