Results 1 to 10 of about 8,819 (284)

Nitrile Oxide, Alkenes, Dipolar Cycloaddition, Isomerization and Metathesis Involved in the Syntheses of 2-Isoxazolines [PDF]

Molecules, 2023
The involvement of 1,3-dipolar cycloaddition (1,3-DP), double bond migration, metathesis, and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C=C bond containing dipolarophiles, in the syntheses of 2-isoxazolines ...
Stanisław Krompiec, Piotr Lodowski, Aneta Kurpanik-Wójcik, Bogumiła Gołek, Angelika Mieszczanin, Aleksandra Fijołek, Marek Matussek, Klaudia Kaszuba   +7 more
doaj   +3 more sources

Electrochemical Synthesis of Isoxazolines: Method and Mechanism. [PDF]

Chemistry, 2022
An electrochemical method for the green and practical synthesis of a broad range of substituted isoxazoline cores is presented. Both aryl and more challenging alkyl aldoximes are converted to the desired isoxazoline in an electrochemically enabled regio‐
Holman SDL, Wills AG, Fazakerley NJ, Poole DL, Coe DM, Berlouis LA, Reid M.   +6 more
europepmc   +7 more sources

Asymmetric Synthesis of Functionalized 2‑Isoxazolines [PDF]

ACS Omega
The asymmetric synthesis of the isoxazoline skeleton was achieved by the oxidation of hydroxylaminoalkyl furan prepared from simple starting materials: 2-methylfuran and (S)-epichlorohydrin. The synthesis features an NBS-mediated oxidation of hydroxylaminoalkyl furan to give an α,β-unsaturated ketone intermediate which cyclized to the isoxazoline.
Beyza Hamur, Fatma Albayrak Halac, Fethiye Yilmazer, Fraser F. Fleming, Irem Kulu, Ramazan Altundas   +5 more
doaj   +4 more sources

Effects of RDL GABA Receptor Point Mutants on Susceptibility to Meta-Diamide and Isoxazoline Insecticides in Drosophila melanogaster [PDF]

Insects
Ionotropic γ-aminobutyric acid (GABA) receptors in insects, specifically those composed of the RDL (resistant to dieldrin) subunit, serve as important targets for commonly used synthetic insecticides. These insecticides belong to various chemical classes,
Tianhao Zhou, Weiping Wu, Suhan Ma, Jie Chen, Jia Huang, Xiaomu Qiao   +5 more
doaj   +4 more sources

3-[N,N-Bis(sulfonyl)amino]isoxazolines with Spiro-Annulated or 1,2-Annulated Cyclooctane Rings Inhibit Reproduction of Tick-Borne Encephalitis, Yellow Fever, and West Nile Viruses. [PDF]

Int J Mol Sci, 2023
Spirocyclic compounds containing heterocyclic moieties represent promising 3D scaffolds for modern drug design. In the search for novel anti-flaviviral agents, we have obtained a series of 3-[N,N-bis(sulfonyl)amino]isoxazolines containing spiro-annulated
Sedenkova KN, Sazonov AS, Vasilenko DA, Andriasov KS, Eremenko MG, Grishin YK, Khvatov EV, Goryashchenko AS, Uvarova VI, Osolodkin DI, Ishmukhametov AA, Averina EB.   +11 more
europepmc   +2 more sources

Novel Synthesis of Dihydroisoxazoles by p-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones [PDF]

Molecules, 2023
This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of p-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This
Caiyun Yang, Sirou Hu, Xinhui Pan, Ke Yang, Ke Zhang, Qingguang Liu, Xiaobing Xin, Jie Li, Jinhui Wang, Xiaoda Yang   +9 more
doaj   +2 more sources

An easy access to chromano-isoxazolines and functionalized isoxazolines [PDF]

ARKIVOC, 2004
2-Allyloxybenzaldoximes on treatment with ceric ammonium nitrate (CAN) at room temperature afforded 3a,4-dihydro-3H-chromeno[4,3-c]isoxazoles while benzaldoximes on interaction with Baylis-Hillman adduct in the presence of CAN produced functionalized isoxazolines.
Biswanath Das, Gurram Mahender, Harish Holla, Joydeep Banerjee   +3 more
doaj   +3 more sources

Comparative analysis of isoxazoline activity on human and canine GABA receptors expressed in Xenopus oocytes [PDF]

Parasites & Vectors
Background Isoxazolines, including sarolaner, lotilaner, afoxolaner and fluralaner, are a class of ectoparasiticides that target gamma-aminobutyric acid receptors (GABARs) in insects and acari.
Heinz Sager, Anouk Sarr, Emmanuelle Kuntz, Lucien Rufener   +3 more
doaj   +2 more sources

Δ2-ISOXAZOLINE DERIVATIVES AS ANTIMICROBIALS [PDF]

Heterocyclic Communications, 2006
The inhibitory effect of newly synthesized C- (anthranyl and biphenyl)-5-substituted-I´2-isoxazolines were characterized by IR, 1H NMR, 13C NMR and CHN anal. and evaluated for their antimicrobial activity against different strains. Strains such as Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, Xanthomonas campestris pvs., Xanthomonas ...
B.S. Priya, Basappa Basappa, K. S. Rangappa   +2 more
openalex   +5 more sources

New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Carbonic anhydrases (CAs) are widespread metalloenzymes which catalyse the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3−) and a proton, relevant in many physiological processes. In the last few years, the involvement of CA activation
Doretta Cuffaro, Riccardo Di Leo, Lidia Ciccone, Alessio Nocentini, Claudiu T. Supuran, Elisa Nuti, Armando Rossello   +6 more
doaj   +2 more sources