Asymmetric Synthesis of Functionalized 2‑Isoxazolines [PDF]
ACS OmegaThe asymmetric synthesis of the isoxazoline skeleton was achieved by the oxidation of hydroxylaminoalkyl furan prepared from simple starting materials: 2-methylfuran and (S)-epichlorohydrin. The synthesis features an NBS-mediated oxidation of hydroxylaminoalkyl furan to give an α,β-unsaturated ketone intermediate which cyclized to the isoxazoline.
Beyza Hamur +5 more
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Nitrile Oxide, Alkenes, Dipolar Cycloaddition, Isomerization and Metathesis Involved in the Syntheses of 2-Isoxazolines [PDF]
Molecules, 2023 The involvement of 1,3-dipolar cycloaddition (1,3-DP), double bond migration, metathesis, and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C=C bond containing dipolarophiles, in the syntheses of 2-isoxazolines ...
Stanisław Krompiec +7 more
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Veterinary Evidence, 2019 PICO questionIn dogs with generalised demodicosis, are isoxazolines as effective as a combined formulation of imidacloprid and moxidectin at reducing mite count and the severity of associated clinical signs?Clinical bottom lineFive single-blinded ...
Sarah Long
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An easy access to chromano-isoxazolines and functionalized isoxazolines [PDF]
ARKIVOC, 2004 2-Allyloxybenzaldoximes on treatment with ceric ammonium nitrate (CAN) at room temperature afforded 3a,4-dihydro-3H-chromeno[4,3-c]isoxazoles while benzaldoximes on interaction with Baylis-Hillman adduct in the presence of CAN produced functionalized isoxazolines.
Biswanath Das +3 more
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MnVI-NP–Catalyzed Generation of Nitrile Oxides: Easy Access to Isoxazolines and Isoxazoles via Stereoselective 1,3-Dipolar Cycloaddition Reactions [PDF]
SynOpen, 2022 The versatility and effectiveness of MnVI-NPs as a catalyst is examined for the generation of nitrile oxides from aldoximes and subsequent 1,3-dipolar cycloaddition reactions.
Yasmin Saima, Saikat Khamarui
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Comparative analysis of isoxazoline activity on human and canine GABA receptors expressed in Xenopus oocytes [PDF]
Parasites & VectorsBackground Isoxazolines, including sarolaner, lotilaner, afoxolaner and fluralaner, are a class of ectoparasiticides that target gamma-aminobutyric acid receptors (GABARs) in insects and acari.
Heinz Sager +3 more
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Novel Synthesis of Dihydroisoxazoles by p-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones [PDF]
Molecules, 2023 This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of p-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This
Caiyun Yang +9 more
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N–O Cleavage reactions of heterobicycloalkene-fused 2-isoxazolines [PDF]
Beilstein Journal of Organic Chemistry, 2014 Transition metal-mediated N–O bond cleavage reactions of heterobicycloalkene-fused 3-methyl-2-isoxazolines were investigated. Optimal cleavage conditions were found with Raney nickel/AlCl3 mediation in aqueous methanol.
Jaipal R. Nagireddy +3 more
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Effects of RDL GABA Receptor Point Mutants on Susceptibility to Meta-Diamide and Isoxazoline Insecticides in Drosophila melanogaster [PDF]
InsectsIonotropic γ-aminobutyric acid (GABA) receptors in insects, specifically those composed of the RDL (resistant to dieldrin) subunit, serve as important targets for commonly used synthetic insecticides. These insecticides belong to various chemical classes,
Tianhao Zhou +5 more
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Effective treatment with afoxolaner (NexGard) of Trixacarus caviae in a pet guinea pig [PDF]
Veterinary Medicine and ScienceTrixacarus caviae is a sarcoptic mange mite infesting guinea pigs. Infestation in immunosuppressed animals produces severe dermatological problems, including alopecia, intense pruritus, hyperkeratosis and non‐dermatological issues (e.g., seizures ...
Georgiana Deak +5 more
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