Results 1 to 10 of about 3,007 (198)

Asymmetric Synthesis of Functionalized 2‑Isoxazolines [PDF]

ACS Omega
The asymmetric synthesis of the isoxazoline skeleton was achieved by the oxidation of hydroxylaminoalkyl furan prepared from simple starting materials: 2-methylfuran and (S)-epichlorohydrin. The synthesis features an NBS-mediated oxidation of hydroxylaminoalkyl furan to give an α,β-unsaturated ketone intermediate which cyclized to the isoxazoline.
Beyza Hamur, Fatma Albayrak Halac, Fethiye Yilmazer, Fraser F. Fleming, Irem Kulu, Ramazan Altundas   +5 more
doaj   +4 more sources

An easy access to chromano-isoxazolines and functionalized isoxazolines [PDF]

ARKIVOC, 2004
2-Allyloxybenzaldoximes on treatment with ceric ammonium nitrate (CAN) at room temperature afforded 3a,4-dihydro-3H-chromeno[4,3-c]isoxazoles while benzaldoximes on interaction with Baylis-Hillman adduct in the presence of CAN produced functionalized isoxazolines.
Biswanath Das, Gurram Mahender, Harish Holla, Joydeep Banerjee   +3 more
doaj   +2 more sources

Nitrile Oxide, Alkenes, Dipolar Cycloaddition, Isomerization and Metathesis Involved in the Syntheses of 2-Isoxazolines [PDF]

Molecules, 2023
The involvement of 1,3-dipolar cycloaddition (1,3-DP), double bond migration, metathesis, and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C=C bond containing dipolarophiles, in the syntheses of 2-isoxazolines ...
Stanisław Krompiec, Piotr Lodowski, Aneta Kurpanik-Wójcik, Bogumiła Gołek, Angelika Mieszczanin, Aleksandra Fijołek, Marek Matussek, Klaudia Kaszuba   +7 more
doaj   +2 more sources

Novel Synthesis of Dihydroisoxazoles by p-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones [PDF]

Molecules, 2023
This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of p-TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This
Caiyun Yang, Sirou Hu, Xinhui Pan, Ke Yang, Ke Zhang, Qingguang Liu, Xiaobing Xin, Jie Li, Jinhui Wang, Xiaoda Yang   +9 more
doaj   +2 more sources

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Pharmaceuticals, 2023
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates.
Xiyue Wang, Qingyun Hu, Hui Tang, Xinhui Pan   +3 more
doaj   +1 more source

in silico Study Reveals Potential Docking Sites of δ 2-isoxazolines derivates for Inhibiting Russell’s Viper PLA2 Toxin [PDF]

Journal of Tropical Life Science, 2021
Snake venom phospholipase A2s (svPLA2s) has been known as the most abundant component and predominant cause of Russell’s viper envenomation. Limitation to serum therapy and considerable pharmacological interest led the researcher to syn-thesized multi ...
Tsaniyah Nur Kholilah, Widodo, Nia Kurniawan   +2 more
doaj   +1 more source

Efficacy of Oral Sarolaner for the Treatment of Feline Otodectic Mange

Pathogens, 2021
Otodectes cynotis is a mite with a cosmopolitan distribution that is the primary agent for the development of otitis externa in feline species. The aim of this study was to evaluate the efficacy of the oral administration of sarolaner for the treatment ...
Diefrey Ribeiro Campos, Jéssica Karoline de Oliveira Chaves, Brena Gava Guimarães, So Yin Nak, Gabriela Pereira Salça de Almeida, Isabela Scalioni Gijsen, Juliana de Moraes Intrieri, Fabio Barbour Scott   +7 more
doaj   +1 more source

3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles

Molecules, 2021
In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various ...
Xinhui Pan, Xiaobing Xin, Ying Mao, Xin Li, Yanan Zhao, Yidi Liu, Ke Zhang, Xiaoda Yang, Jinhui Wang   +8 more
doaj   +1 more source

New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Carbonic anhydrases (CAs) are widespread metalloenzymes which catalyse the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3−) and a proton, relevant in many physiological processes. In the last few years, the involvement of CA activation
Doretta Cuffaro, Riccardo Di Leo, Lidia Ciccone, Alessio Nocentini, Claudiu T. Supuran, Elisa Nuti, Armando Rossello   +6 more
doaj   +1 more source

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

Ultrasonics Sonochemistry, 2021
In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA)
Aicha Talha, Cécile Favreau, Maxence Bourgoin, Guillaume Robert, Patrick Auberger, Lahcen EL Ammari, Mohamed Saadi, Rachid Benhida, Anthony R. Martin, Khalid Bougrin   +9 more
doaj   +1 more source