Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie
Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl +6 more
wiley +1 more source
Synthetic Studies Directed Toward Streptenol D: Enantioselective Preparation of the 3,5-diacetoxy-6\u3cem\u3eE\u3c/em\u3e,8\u3cem\u3eE\u3c/em\u3e-decadiene Segment [PDF]
, 1998 The enantioselective preparation of 2-(3′R,5′R-diacetoxy-6E,8E-decadienyl)-1,3-dioxane, (+)-13, is described. This synthesis of the skeleton of streptenol D utilizes the ability of a diene-complexed (tricarbonyl)iron unit to serve as a protecting and ...
Dasgupta, Bireshwar, Donaldson, William
core +1 more source
Glucopyranosylidene-Spiro-Thiazolinones: Synthetic Studies and Determination of Absolute Configuration by TDDFT-ECD Calculations [PDF]
, 2017 Reactions of O-peracylated C-(1-bromo-β-d-glucopyranosyl)formamides with thioamides furnished the corresponding glucopyranosylidene-spiro-thiazolin-4-one.
Kun, Sándor +4 more
core +2 more sources
The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl +6 more
wiley +1 more source
Thioxanthone: A Benchmark Photocatalyst for Organic Synthesis
ChemCatChem, Volume 17, Issue 16, August 18, 2025.Thioxanthone is a highly versatile and effective organocatalyst for photochemical applications, with its low‐toxicity, metal‐free structure driving growing interest in sustainable photocatalysis. Building on our previous 2021 review, this update covers advances from 2021–2025 in thioxanthone‐based synthetic organic photochemistry – excluding ...
Vera P. Demertzidou +2 more
wiley +1 more source
Cycloaddition reactions of nitrosoalkenes, azoalkenes and nitrile oxides mediated by hydrotalcite [PDF]
, 2012 Mg:Al 3:1 hydrotalcite (Ht), used in catalytic quantities, promotes the generation of nitrosoalkenes, azoalkenes and nitrile oxides. These can be intercepted in situ by heterocycles and olefins in [4+2] and [3+2] cycloaddition reactions, producing ...
Lemos, A., Lourenço, J. P.
core
Reaction of Nitrones with Phosphinylallenes: DFT Mechanistic Investigations
European Journal of Organic Chemistry, Volume 28, Issue 28, July 29, 2025.The mechanism of the reaction between phosphinylallenes and nitrones is investigated by DFT calculations to elucidate the overall pathway and the stereochemical outcome. The initial (3+2) cycloaddition delivers an unstable isoxazolidine ylidene intermediate, spontaneously rearranging to the 4‐phosphinylpyrrolidin‐3‐one via a radical pathway. This study
Rayhane Hammami +5 more
wiley +1 more source
Asymmetric Lewis acid-catalyzed 1,3-dipolar cycloadditions [PDF]
, 2017 Highly tuned, one-point binding chiral iron and ruthenium complexes selectively coordinate and activate α,β-unsaturated aldehydes and ketones toward asymmetric catalytic Diels-Alder cycloaddition reactions.
Brinkmann, Yasmin +3 more
core
Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions [PDF]
, 2012 In this article we present a fast and efficient methodology for biochemical surface patterning under extremely mild conditions. Micropatterned azide/benzaldoxime-surfaces were prepared by microcontact printing of a heterobifunctional cyclooctyne oxime ...
Arlinghaus, Heinrich F +6 more
core +1 more source
N–O Cleavage reactions of heterobicycloalkene-fused 2-isoxazolines
Beilstein Journal of Organic Chemistry, 2014 Transition metal-mediated N–O bond cleavage reactions of heterobicycloalkene-fused 3-methyl-2-isoxazolines were investigated. Optimal cleavage conditions were found with Raney nickel/AlCl3 mediation in aqueous methanol.
Jaipal R. Nagireddy +3 more
doaj +1 more source