Results 151 to 160 of about 3,713 (190)

Causal links between multi-domain risk factors and intervertebral disc degeneration: a systematic review and meta-analysis of Mendelian randomization studies. [PDF]

BMC Musculoskelet Disord
Zhang H, Tian J, Lu Y, Yu D, Wu H, Lu Y, Yu L, Luo Z.   +7 more
europepmc   +1 more source

Dysregulated methylation-ubiquitination crosstalk accelerates intervertebral disc degeneration via MED12 destabilization and cGAS/STING activation. [PDF]

J Clin Invest
Liang H, Zhu D, Du Z, Li X, Shi R, Lei J, Tong B, Xu H, Wu D, Zhou X, Du Y, Ou Z, Wei J, Peng S, Ke W, Liao Z, Wang B, Wang K, Feng X, Song Y, Yang C.   +20 more
europepmc   +1 more source

Breaking the degenerative triad: Microenvironment reprogramming biomaterials for intervertebral disc regeneration. [PDF]

Bioact Mater
Zhao X, Han X, Hu Z, Chen Y, Wang X, Liu Q, Hu X, Zhang Q, Yue J, Ge Y, Ma Y, Li Y, Zhang Z, Li F, Chen W, Zhang Y.   +15 more
europepmc   +1 more source

The Long and Short of It: Exploring IVDD and Goniometry in Miniature Dachshunds

openaire   +1 more source

KMT2A Regulates the Autophagy-GATA4 Axis Through METTL3-Mediated m6A Modification of ATG4a to Promote NPCs Senescence and IVDD Progression

Bone Research
Abstract Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses. However, the specific mechanisms that regulate the senescence of NPCs remain unknown.
Aimin Wu, Xinzhou Wang, Ouqiang Wu
exaly   +5 more sources

Cross-Disease Biomarker Identification Reveals Shared Diagnostic Biomarkers for IVDD and NAFLD via Bulk and Single-Cell RNA Sequencing [PDF]

Frontiers in Molecular Neuroscience
IntroductionIntervertebral disc degeneration (IVDD) and non-alcoholic fatty liver disease (NAFLD) represent major global health burdens. Although recent evidence points to a potential association between these two conditions, the underlying molecular mechanisms remain poorly understood.
Kaiqiang Sun, Chen Yan, Wenbo Lin
exaly   +4 more sources