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METTL3-Mediated miR-4534 Maturation Promotes IVDD Progression by Targeting the Sirt6-Mediated Nrf2/HO-1 Pathway

Archives of Medical Science
IntroductionIntervertebral disc degeneration (IVDD) is a significant contributor to the development of discogenic low back pain and impairment. Apoptosis and degradation of the extracellular matrix (ECM) have also been reported to be major factors in IVDD.
Ran, Bo, Yang, Ziqing, Li, Mengzhao
exaly   +5 more sources

Targeting IL-1β expression in IVDD [PDF]

Nature Reviews Rheumatology, 2020
Jessica McHugh
exaly   +3 more sources

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Clinical case of intervertebral disc disease (IVDD)

III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS, 2023
IVDD is an intervertebral disc injury characterized by extrusion of the disc into the spinal canal, compressing the spinal cord and causing limb paralysis. Diagnosis involves anamnesis, clinical history, physical and neurological examination. Treatment is clinical or surgical, depending on the degree, extent and location.
Alice Elisa Pizzutti, Luíza Fruett M. de Lima   +1 more
openaire   +1 more source

Efficiency of Dual siRNA-Mediated Gene Therapy for Intervertebral Disc Degeneration (IVDD)

Spine Journal, 2019
One of the common causes of low back pain is intervertebral disc degeneration. The pathophysiology of disc degeneration involves apoptosis of nucleus pulposes cells and degradation of extra cellular matrix (ECM). Caspase 3 plays a central role in apoptosis and the ADAMTS5 (A Disintegrin and Metalloproteinase with Thrombospondin motifs 5) gene plays a ...
Rajkiran Reddy Banala, Ghulam Hassan Dar, A V Gurava Reddy   +2 more
exaly   +3 more sources

Experience With the IVDD Performance Evaluations of the ADVIA Centaur Infectious Disease Assays

Journal of Clinical Virology, 2004
The adoption of the new European Directive on In Vitro Diagnostics (IVD Directive, 1998) by all western and the majority of the eastern European countries requires diagnostic manufacturers to conduct extensive performance evaluations to generate data for supporting and validating their performance claims.
Josef van Helden
exaly   +3 more sources

Targeting NP Cell Senescence in IVDD

Nature Reviews Rheumatology
exaly   +3 more sources

cPLA2 as a Therapeutic Target in Chondrocytes for OA and IVDD

Nature Reviews Rheumatology
Holly Webster
exaly   +3 more sources

Lactylation of SOD1 Promotes Oxidative Damage in IVDD

Nature Reviews Rheumatology
Jessica McHugh
exaly   +3 more sources

Periplocin Targets LRP4 to Regulate Metabolic Homeostasis and Anti-Inflammation for the Treatment of IVDD

Phytomedicine
Intervertebral disc degeneration (IVDD) is characterized by deteriorating intervertebral discs, leading primarily to low back pain and leg pain. Most current treatments for IVDD primarily address symptoms without targeting the underlying degenerative process. Moreover, tumor necrosis factor-α (TNF-α)-mediated inflammation and degradation of the nucleus
Yuanqiang Zhang, Kaiwen Liu, Qunbo Meng
exaly   +3 more sources

Assessing the Toxicological Impact of PET-MPs Exposure on IVDD: Insights From Network Toxicology and Molecular Docking

Journal of Environmental Management
Polyethylene terephthalate microplastics (PET-MPs) have emerged as a significant environmental concern due to their persistence and potential health hazards. Their role in degenerative diseases, particularly intervertebral disc degeneration (IVDD), remains poorly understood, highlighting the need for systematic evaluation of their molecular toxicity ...
Jinqing Wang, Fengguang Yang, Xuewen Kang   +2 more
exaly   +3 more sources