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Molecular Crosstalk Between MASLD and IVDD Revealed Through Integrated Biomarker Discovery Analysis

Frontiers in Immunology
Background Non-alcoholic fatty liver disease (NAFLD), recently retermed as metabolic dysfunction-associated steatotic liver disease (MASLD), and intervertebral disc degeneration (IVDD) are major health burdens with rising prevalence. Despite affecting different organ systems, emerging evidence suggests potential
Wang, Guohao, Liu, Yongming, Shen, Xingchao   +2 more
exaly   +3 more sources

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Referral Nursing – Inter-Vertebral Disc Disease (IVDD) in Dogs

Veterinary Nursing Journal, 2011
ABSTRACT:Inter-vertebral disc disease (IVDD) occurs when an extrusion or protrusion of inter-vertebral disc material occurs within the spinal cord. Clinical signs of IVDD depend on several factors which include the type of herniation, the location of the lesion, and the extent of the protrusion of disc material into the spinal canal.Prognosis depends ...
exaly   +2 more sources

Automatic Mask Creation and Feature Analysis for Detectionof IVDD in Canines

5th International Conference on Computer Sciences and Convergence Information Technology, 2010
Intervertebral disc disease (IVDD) is a condition that affects both humans and canines. This disease is painful and degrades the quality of life for those that suffer from it. The current diagnostic methods for this disease are Magnetic Resonance Imaging (MRI) and/or Computed Axial Tomography (CAT scan).
Scott E Umbaugh, Dominic J Marino, Catherine A Loughin   +2 more
exaly   +2 more sources

Tuina Inhibits Chondrocyte Apoptosis by Regulating the FAK/PI3K/Akt Pathway in Rabbits With IVDD

Combinatorial Chemistry and High Throughput Screening
Background: Intervertebral disc degeneration (IVDD), a key contributor to degenerative spinal diseases such as cervical spondylosis, significantly influences the quality of life of patients. Tuina, historically employed in the clinical management of cervical spondylosis, has demonstrated positive therapeutic outcomes; however, the mechanism of Tuina ...
Jiayi Liu, Ailin Li
exaly   +3 more sources

miR-4478 Promotes Ferroptosis of Nucleus Pulposus Cells Through Targeting SLC7A11 to Induce IVDD

Folia Biologica
Nucleus pulposus cells (NPC) are important for the development of intervertebral disc degeneration (IVDD). miR-4478 can aggravate IVDD, but whether it can aggravate IVDD by regulating ferroptosis in NPC remains unclear. The optimal level of ferroptosis activator RSL3 for eliciting ferroptosis in NPC was screened by Western blot and
Long Jia
exaly   +3 more sources

Dmab/ivDde protected diaminodiacids for solid-phase synthesis of peptide disulfide-bond mimics

Tetrahedron Letters, 2017
The use of pre-prepared diaminodiacids has been established as an effective approach for the chemical synthesis of peptide disulfide bond mimics. A technical problem often encountered in the implementation of the diaminodiacids strategy is the use of heavy metal reagents to remove the side-chain protecting groups.
Yang Xu, Tao Wang, Chao-Jian Guan, Yi-Ming Li, Lei Liu, Jing Shi, Donald Bierer   +6 more
openaire   +1 more source

Navigating the Transition: From IVDD to IVDR Compliance

Proceedings of the 1st International Conference on Frontiers in Physical and Chemical Sciences: Exploring New Horizons, FPCS 2024, 13-14 November 2024, Bengaluru, Karnataka, India
Rashmitha R, Shivanand K Mutta
exaly   +2 more sources

Identification and Validation of Diagnostic Biomarkers for Osteoarthritis Coexisting with IVDD and LFH via Bioinformatics and Machine Learning

Current Medicinal Chemistry
Introduction: Osteoarthritis (OA), intervertebral disc degeneration (IVDD), and ligamentum flavum hypertrophy (LFH) frequently manifest concurrently in the aging population. This study aims to identify potential diagnostic genes associated with these three interconnected conditions.
Weiqi, Han, Zhibo, Deng, Zhao, Lin, Jun, Luo, Jie, Xu   +4 more
openaire   +2 more sources

Evaluation of ivDde as a quasi-orthogonal protecting group for Fmoc solid-phase peptide synthesis

2006
Modifications of the side-chains of lysine, ornithine, and diaminopropionic acid (Dpr) can be very useful, if an appropriate protection scheme is available. In 1993, Bycroft and coworkers introduced the quasi-orthogonal amino protecting group Dde [l-(4,4-dimethyl2,6-dioxocyclohex-1-ylidene)-ethyl] for Fmoc solid-phase peptide synthesis [1].
R. Randy Wilhelm, Ananth Srinivasan, Michelle A. Schmidt   +2 more
openaire   +1 more source

Biomimetic Hydrogen‐Generating Piezoelectric Hydrogel for Dual Glucose Regulation and Mitophagy Activation in Diabetes‐Induced IVDD

Advanced Functional Materials
Abstract Glucose metabolic imbalance is central to metabolic disorders like diabetes, while mitochondrial dysfunction‐driven reactive oxygen species (ROS) overproduction worsens disease progression. Traditional therapies primarily focus on regulating glucose levels but fail to restore mitophagy.
Lei Liu, Yucheng Ji, Lefeng Su, Yubo Feng, Yuwei Hu, Yuduo Zhu, Zilong Jin, Zhanyi Chen, Lan Li, Hongxing Shen, Lifeng Lao, Yingchao Han, He Xu   +12 more
openaire   +1 more source