Results 31 to 40 of about 26,766 (239)

Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

Frontiers in Molecular Neuroscience, 2012
Ivermectin is a gold standard anthelmintic drug that works by potently depressing neuronal activity and muscular contractility in arthropods and nematodes. At the molecular level, ivermectin activates inhibitory glutamate-gated chloride channels (GluClRs)
Timothy eLynagh, Joe eLynch
doaj   +1 more source

Ivermectin for Covid-19

, 2020
Discussion of scholar papers published on Ivermectin and of some news that we can find about its use for Covid-19. A list of clinical trials is also given. The discussion was made in a series of versions from 14 June to 27 July 2020. For what concerns scholar papers, we report among them a preprint posted on 10 June in MedRχiv, which concludes that ...
openaire   +2 more sources

Impact of ivermectin components on Anopheles dirus and Anopheles minimus mosquito survival

Parasites & Vectors
Background Ivermectin mass drug administration to humans or livestock is a potential vector control tool for malaria elimination. Racemic ivermectin is composed of two components, namely a major component (> 80%; ivermectin B1a), which has an ethyl group
Pattarapon Khemrattrakool, Thitipong Hongsuwong, Phornpimon Tipthara, Rattawan Kullasakboonsri, Theerawit Phanphoowong, Patchara Sriwichai, Borimas Hanboonkunupakarn, Podjanee Jittamala, Joel Tarning, Kevin C. Kobylinski   +9 more
doaj   +1 more source

Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth

Frontiers in Pharmacology, 2021
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. Ivermectin, an antiparasitic drug, has been shown to possess anti-inflammation, anti-virus, and antitumor properties. However, whether ivermectin affects
Shican Zhou, Hang Wu, Wenjuan Ning, Xiao Wu, Xiaoxiao Xu, Yuanqiao Ma, Xingwang Li, Junhong Hu, Chenyu Wang, Junpeng Wang   +9 more
doaj   +1 more source

Spontaneous Resolution of Delusional Infestation Upon Eliminating Social Isolation: A Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Delusional infestation (DI) is a psychiatric condition involving a false belief of parasitic infection. A 79‐year‐old woman with persistent pruritus and scabies delusion refused antipsychotics but improved after relocating to assisted living.
Veranca Shah, Jesse J. Keller
wiley   +1 more source

Challenges and opportunities in mitigating sarcoptic mange in wild South American camelids

The Journal of Wildlife Management, EarlyView.
Wild South American camelids—vicuña and guanaco—face threats from sarcoptic mange, a contagious skin disease linked to severe population declines. Despite its impact, major gaps remain in understanding disease dynamics. This review summarizes current knowledge, identifies key data and management gaps, and outlines urgent actions for effective ...
Alynn M. Martin, Emiliana Isasi‐Catalá, Marília Salgado‐Caxito, Ana Gallegos, Leonardo Hostos‐Olivera, Paulo Colchao‐Claux, Steve Smith, L. Fabian Beltran‐Saavedra, Catherine Dougnac, Camila Germana, Mariana Montoya, Scott Carver, Paul C. Cross, Christian Walzer   +13 more
wiley   +1 more source

Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide‐susceptible and resistant strains

Pest Management Science, EarlyView.
Two small molecules, SACC‐0039590 and SACC‐0428788, killed cattle fever tick, R. microplus, susceptible Deutch strain and pyrethroid resistant Arauquita strain larvae. SACC‐0039590 at 1 mM decreased the reproductive parameters of Deutch females. Abstract BACKGROUND Resistance to acaricides underscores the need for tick control alternatives.
Waleed M. Arafa, Kimberly H. Lohmeyer, Patricia V. Pietrantonio   +2 more
wiley   +1 more source

Discovery of murayaquinone from an endophytic bacterium Streptomyces sp. AN140557 as a potent inhibitor of the pine wood nematode, Bursaphelenchus xylophilus

Pest Management Science, EarlyView.
Murayaquinone isolated from the pine endophyte Streptomyces sp. AN140557 exhibits potent, dose‐dependent nematicidal activity and egg‐hatching inhibition against the pine wood nematode. It effectively inhibited pine wilt disease in greenhouse tests, suggesting potential as a promising biocontrol agent.
Min‐Kyoung Kang, Hyeon‐Ji Kim, Jong‐Hoon Kim   +2 more
wiley   +1 more source

Complexin in ivermectin resistance in body lice. [PDF]

PLoS Genetics, 2018
Ivermectin has emerged as very promising pediculicide, particularly in cases of resistance to commonly used pediculicides. Recently, however, the first field-evolved ivermectin-resistance in lice was reported.
Nadia Amanzougaghene, Florence Fenollar, Claude Nappez, Amira Ben-Amara, Philippe Decloquement, Said Azza, Yassina Bechah, Eric Chabrière, Didier Raoult, Oleg Mediannikov   +9 more
doaj   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source