Results 51 to 60 of about 20,113 (176)

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source

Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients.

PLoS ONE, 2020
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not ...
Daniel Camprubí, Alex Almuedo-Riera, Helena Martí-Soler, Alex Soriano, Juan Carlos Hurtado, Carme Subirà, Berta Grau-Pujol, Alejandro Krolewiecki, Jose Muñoz   +8 more
doaj   +1 more source

Reading Nietzsche in an Age of Conspiracy Theories

Modern Theology, EarlyView.
Abstract This essay considers Friedrich Nietzsche's critique of Christian morality as a template for interpreting the epistemology of modern conspiracy theorists. The first section elucidates Nietzsche's notion of ressentiment as it can be applied to contemporary conspiracism. The effectiveness of this comparative assessment thus raises the question of
J.W. Olson
wiley   +1 more source

Dupilumab‐Associated Palmar Erythema Successfully Treated With Fluconazole

Australasian Journal of Dermatology, EarlyView.
Katina J. Selvaraj, Geoffrey Lee
wiley   +1 more source

Drivers of Noncompliance With Vaccine Mandates—The Interplay Between Distrust, Rationality, Morality, and Social Motivation

Regulation &Governance, EarlyView.
ABSTRACT COVID‐19 amplified the issue of public resistance to government vaccination programs. Little attention has focused on people's moral reasons for noncompliance, which differ from—but often build upon—the epistemic claims they make about vaccine safety and efficacy, disease severity, and the trustworthiness of government. This study explores the
Katie Attwell, Hang Duong, Amy Morris, Leah Roberts, Mark Navin   +4 more
wiley   +1 more source

What Goes First? Effects of Starvation on the Body Condition of a Neotropical Dung Beetle

Entomologia Experimentalis et Applicata, Volume 174, Issue 4, Page 321-328, April 2026.
We investigated how prolonged starvation affects key physiological traits in the dung beetle Dichotomius bos. Prolonged starvation leads to significant reductions in body dry mass and fat reserves, while muscle mass remains unchanged. These findings indicate that dung beetles prioritize the maintenance of locomotor muscles while mobilizing stored ...
Leonardo Vilas‐Bôas M. P. de Cerqueira, Renato Portela Salomão, Damián Villaseñor‐Amador, Andressa Fraga Cotta, Pedro Lucas Moreira de Oliveira, César Murilo de Albuquerque Correa   +5 more
wiley   +1 more source

Differential susceptibilities of Anopheles albimanus and Anopheles stephensi mosquitoes to ivermectin

Malaria Journal, 2018
Background Vector control is a crucial element of anti-malaria campaigns and works best when there is a thorough knowledge of the biology and behaviour of the Anopheles vector species responsible for transmitting malaria within a given locale.
Staci M. Dreyer, Kelsey J. Morin, Jefferson A. Vaughan   +2 more
doaj   +1 more source

Rainfall shapes the physiological condition, but not the body size, of an introduced dung beetle in Brazilian pastures

Ecological Entomology, Volume 51, Issue 2, Page 346-355, April 2026.
Understanding rainfall‐driven physiological shifts in dung beetles is crucial to predict how climate change may affect the fitness and persistence of key insect species in tropical pastures. We compared body size, dry, lipid and muscle masses of Digitonthophagus gazella collected during dry and rainy seasons in Brazilian pastures to assess the effects ...
Cleilsom M. Cristaldo, Renato Portela Salomão, Pedro Lucas Moreira de Oliveira, Alfredo Raúl Abot, César Murilo de Albuquerque Correa   +4 more
wiley   +1 more source

Efficacy of Two Doses of Ivermectin Tablet in Treatment of Scabies in Comparison to Once Application of 5% Permethrin Lotion – A Randomized Controlled Trial

Indian Journal of Community Medicine
Background: Scabies may cause community outbreaks without early diagnosis and appropriate treatment. Oral ivermectin offsets some of the challenges associated with topical 5% permethrin application for treating scabies.
Debkumar Pal, Priyamadhaba Behera, Mythry Ravichandran, Dinesh P. Sahu, Chandra S. Sirka, Binod K. Patro, Siddharth Dash, Manish Taywade   +7 more
doaj   +1 more source

Imperatorin Mitigates Rosacea‐Like Inflammation by Modulating the Crosstalk Between JNK1 and STAT1

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
IMP treatment disrupts the interaction between JNK1 and STAT1, thereby attenuating STAT1 activity. This interference subsequently diminishes the phosphorylation and nuclear translocation of STAT1, which ultimately results in a reduced production of inflammatory cytokines and chemokines.
Xiaoxue Wang, Zexin Zhu
wiley   +1 more source