Results 51 to 60 of about 67,505 (283)

Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction

Frontiers in Pharmacology, 2022
Pancreatic cancer is an aggressive cancer characterized by high mortality and poor prognosis, with a survival rate of less than 5 years in advanced stages. Ivermectin, an antiparasitic drug, exerts antitumor effects in various cancer types.
D. Lee, H. Kang, So Yi Kim, Myeong Jin Kim, Jae Woong Jeong, Woosol Chris Hong, S. Fang, Hyung Sun Kim, Yun-Sun Lee, H. Kim, Joon Seong Park   +10 more
semanticscholar   +1 more source

Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2

In Vivo, 2020
Background/Aim: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One drug that has attracted interest is the antiparasitic compound ivermectin, a macrocyclic lactone ...
S. Lehrer, P. Rheinstein
semanticscholar   +1 more source

Ivermectin susceptibility, sporontocidal effect, and inhibition of time to re-feed in the Amazonian malaria vector Anopheles darlingi

Malaria Journal, 2017
Background Outdoor malaria transmission hinders malaria elimination efforts in the Amazon region and novel vector control tools are needed. Ivermectin mass drug administration (MDA) to humans kills wild Anopheles, targets outdoor-feeding vectors, and can
Kevin C. Kobylinski, Karín S. Escobedo-Vargas, Victor M. López-Sifuentes, Salomón Durand, Edward S. Smith, G. Christian Baldeviano, Robert V. Gerbasi, Sara-Blythe Ballard, Craig A. Stoops, Gissella M. Vásquez   +9 more
doaj   +1 more source

Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model

Microorganisms, 2022
Ivermectin, an FDA-approved antiparasitic drug, has been reported to have in vitro activity against SARS-CoV-2. Increased off-label use of ivermectin for COVID-19 has been reported.
Caroline S. Foo, Rana Abdelnabi, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Birgit Weynand, Johan Neyts   +6 more
doaj   +1 more source

Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study

PLoS ONE, 2021
Background Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infection
P. Behera, B. Patro, A. Singh, P. Chandanshive, Ravikumar S R, S. Pradhan, S. Pentapati, Gitanjali Batmanabane, P. Mohapatra, B. Padhy, S. Bal, S. Singh, R. Mohanty   +12 more
semanticscholar   +1 more source

Ivermectin for onchocercal eye disease (river blindness).

, 2012
BACKGROUND: It is believed that ivermectin (a microfilaricide) could prevent blindness due to onchocerciasis. However, when given to everyone in communities where onchocerciasis is common, the effects of ivermectin on lesions affecting the eye are ...
Ejere, Henry OD, Evans, Jennifer R, Schwartz, Ellen, Wormald, Richard   +3 more
core   +1 more source

Lymphatic Filariasis Control in Tanzania: Effect of Six Rounds of Mass Drug Administration with Ivermectin and Albendazole on Infection and Transmission. [PDF]

, 2013
Control of lymphatic filariasis (LF) in most countries of sub-Saharan Africa is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole, in order to interrupt transmission. We present findings from a detailed study
C Chaccour, DJ Tisch, DW Meyrowitsch, DW Meyrowitsch, DW Meyrowitsch, E Michael, E Michael, E Michael, EM Pedersen, Erling M Pedersen, FO Richards, GJ Weil, GJ Weil, GJ Weil, H Joseph, HM Joseph, JD King, JE McMahon, JE McMahon, JL Liang, JM Mlandonicky, KC Kobylinski, KD Ramaiah, KY Won, LM Zeldenryk, M Parker, MN Malecela, Mwele N Malecela, N Kolstrup, O Mitja, Paul E Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PE Simonsen, PJ Hotez, RMR Ramzy, RT Rwegoshora, Stephen M Magesa, WHO, WHO, William N Kisinza, YA Derua, Yahya A Derua   +48 more
core   +1 more source

Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach

Future Virology, 2021
Aim: COVID-19 is currently the biggest threat to mankind. Recently, ivermectin (a US FDA-approved antiparasitic drug) has been explored as an anti-SARS-CoV-2 agent.
Abhigyan Choudhury, N. Das, Ritwik Patra, M. Bhattacharya, Pratik Ghosh, B. C. Patra, S. Mukherjee   +6 more
semanticscholar   +1 more source

Comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbits

German Journal of Veterinary Research, 2022
The present study aimed to investigate the effects of nano-capsulated ivermectin on the liver and kidney function and oxidative status in mite infested-rabbits, compared to ivermectin. Additionally, the ivermectin residue profile in adipose tissue, liver,
Azza Abdelmoteleb, Dalia Elmasry, Fatma Amro, Reham Mahmoud   +3 more
doaj   +1 more source

Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]

, 2007
Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas, Chang, Cymes, Cymes, Dahan, England, Gandhi, Grosman, Han, Hawthorne, Hawthorne, Hemmings, Kondratskaya, Kondratskaya, Law, Lee, Lewis, Lobo, Lynch, Lynch, Lynch, Miyazawa, Muroi, O'Shea, Paas, Rajendra, Shan, Unwin, Unwin, Webb, Wilson   +30 more
core   +3 more sources