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Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus Infection Promotes Immune Recognition by Natural Killer Cells. [PDF]
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Evaluating Neural Network Performance in Predicting Disease Status and Tissue Source of JC Polyomavirus from Patient Isolates Based on the Hypervariable Region of the Viral Genome. [PDF]
Pike AMC +3 more
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Development of intranuclear inclusions of human polyomavirus JC.
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JC Polyomavirus Infection Potentiated by Biologics
Infectious Disease Clinics of North America, 2020The risk of JC polyomavirus encephalopathy varies among biologic classes and among agents within the same class. Of currently used biologics, the highest risk is seen with natalizumab followed by rituximab. Multiple other agents have also been implicated.
Ashrit, Multani, Dora Y, Ho
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The biology of JC polyomavirus
Biological Chemistry, 2017Abstract JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs in people with underlying immunodeficiency or in individuals being treated with potent immunomodulatory therapies.
Benedetta Assetta, Walter J. Atwood
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Fifty Years of JC Polyomavirus: A Brief Overview and Remaining Questions [PDF]
Abigaïl L Atkinson, Walter Atwood
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Evolution of human polyomavirus JC
Microbiology, 2000More than 20 near full-length genome sequences have been reported for human polyomavirus JC (JCV). These have previously been classified into seven genotypes, and additional subtypes, which exhibit geographical associations. One of these genotypes, Type 4, has been suggested to be a recombinant of Types 1 and 3.
J N, Hatwell, P M, Sharp
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Infection with polyomavirus JC
BMJ, 2011Is highly prevalent, and can be fatal in immunocompromised people The recent discovery of new neurological syndromes that result from neuronal infection with polyomavirus JC, also known as JC virus, and the presence of this virus in the grey matter are currently under debate.1 It has been suggested that JC virus is associated with cognitive decline ...
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