Results 131 to 140 of about 4,990 (166)

JC polyomavirus in the aetiology and pathophysiology of glial tumours

Neurosurgical Review, 2015
Glial brain tumours with their poor prognosis, limited treatment modalities and unclear detailed pathophysiology represent a significant health concern. The purpose of the current study was to investigate and describe the possible role of the human polyomavirus JC as an underlying cancerogenic or co-cancerogenic factor in the complex processes of glial
Tihomir, Eftimov, Yavor, Enchev, Iliya, Tsekov, Plamen, Simeonov, Zlatko, Kalvatchev, Elitsa, Encheva   +5 more
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Characterization of JC human polyomavirus infection in a Portuguese population

Journal of Medical Virology, 2010
AbstractJC virus (JCV) is ubiquitous in the human population, infecting children asymptomatically. After primary infection, JCV persists in the host throughout life and is often excreted in the urine. Two hundred thirty‐four urine samples and 78 serum samples, collected from 171 healthy individuals and 63 patients infected with HIV, were used to ...
Ana, Matos, Vitor, Duque, Sílvia, Beato, João Poiares, da Silva, Eugene, Major, António, Meliço-Silvestre   +5 more
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Haemorrhagic cystitis and polyomavirus JC infection in ataxia telangiectasia

Journal of Pediatric Urology, 2009
We report the case of a young adolescent with ataxia telangiectasia (AT) and life-threatening haemorrhage from the bladder due to a combination of bladder wall telangiectasis, immunosuppressive therapy and an infection with polyomavirus JC. BK and JC are both members of the polyomavirus family. BK virus is a known cause of haemorrhagic cystitis in bone-
Martin, Christmann, Sonja, Heitkamp, Evelyn, Lambrecht, Kristina, Doerries, Ralf, Schubert, Stefan, Zielen   +5 more
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Human Polyomavirus JC and Progressive Multifocal Leukoencephalopathy

2013
John Cunningham virus (JCV) is a double-stranded DNA polyomavirus isolated in 1971 by Padgett et al. from the brain of a patient with Hodgkin disease. Viral DNA is transcripted on both strands and it encodes for the early genes counterclockwise and for the late genes clockwise.
MISCHITELLI, MONICA, FIORITI, DANIELA, BELLIZZI, ANNA, ANZIVINO, ELENA, CHIARINI, Fernanda, PIETROPAOLO, Valeria Antonietta   +5 more
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Immunosuppression increases latent infection of brain by JC polyomavirus

Pathology, 2011
Progressive multifocal leukoencephalopathy (PML) is caused by reactivation of JC polyomavirus (JCV). Increased JCV reactivation in kidney, as indicated by JCV viruria is reported during immunosuppression; however, the relevance of systemic to neural reactivation remains unknown.Brain and kidney tissue from 138 non-PML patients (78 immunocompetent; 60 ...
Julianne, Bayliss, Tanja, Karasoulos, Scott, Bowden, Ivana, Glogowski, Catriona Ann, McLean   +4 more
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Seroepidemiology of the Human Polyomavirus JC in a Cohort of Italian Infants

Journal of Clinical Virology, 2015
BACKGROUND: JC virus (JCV) is a widespread member of the Polyomaviridae family. Following the primary infection, that occurs asymptomatically during childhood, JCV persists as latent infection in the host. In patients with impaired immune function, JCV can reactivate and induce Progressive Multifocal Leukoencephalopathy (PML), a demyelinating disease ...
ELIA, FRANCESCA, L. Pellegrinelli, D. Galati, SIGNORINI, LUCIA, DALLARI, SIMONE, VILLANI, SONIA, BELLA, RAMONA, S. Binda, V. Primache, FERRANTE, PASQUALE, DELBUE, SERENA   +10 more
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Human Polyomavirus JC and BK Persistent Infection

2007
Primary contact with the human polyomaviruses (HPV) is followed by lifelong persistence of viral DNA in its host. The most prominent organs affected are the kidney, the Central Nervous System (CNS)and the hematopoietic system. Under impairment of immune competence limited activation of virus infection can be followed by prolonged virus multiplication ...
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Kidney graft loss associated with JC polyomavirus nephropathy

Journal of Nephrology, 2009
Abstract This is the first case of documented treatment failure of JCV nephritis, despite a reduction of immunosuppressive agents and the use of antiviral therapy. We consistently detected high levels of JCV viremia, which correlated with the progressive deterioration of the graft and caused the final loss of the kidney, suggesting ...
Davide, Rolla, Claudio G, Giacomazzi, Raffaella, Gentile, Jean Louis, Ravetti, Giuseppe, Cannella, Oliviero E, Varnier   +5 more
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The quantification of JC polyomavirus in wastewater samples in Ahvaz, Iran

International Journal of Environmental Health Research
The presence of human JC polyomavirus (JCPyV) in wastewater serves as a notable marker of human fecal and urine of infected individuals. Therefore, this study investigated the occurrence of JCPyV in wastewater samples from diverse sites across Ahvaz city. To this aim, 60 wastewater samples were collected from different areas.
Parvaneh, Bahrami, Afshin, Takdastan, Manoochehr, Makvandi, Sahand, Jorfi, Mohammad, Karimi Baba Ahmadi, Abdolkazem, Neisi   +5 more
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African Origin of Polyomavirus JC and Implications for Prehistoric Human Migrations

Journal of Molecular Evolution, 2003
The presence of distinctive types of JC virus (JCV) in the main ethnic groups suggests a close coevolution with the human host. However, phylogenetic trees of JCV show a basal clade of European lineages (Types 1/4), whereas trees of human genes are coherent in placing the first split between African and non-African populations.
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