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The biology of JC polyomavirus
Biological Chemistry, 2017Abstract JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs in people with underlying immunodeficiency or in individuals being treated with potent immunomodulatory therapies.
Benedetta Assetta, Walter J. Atwood
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Evolution of human polyomavirus JC
Microbiology, 2000More than 20 near full-length genome sequences have been reported for human polyomavirus JC (JCV). These have previously been classified into seven genotypes, and additional subtypes, which exhibit geographical associations. One of these genotypes, Type 4, has been suggested to be a recombinant of Types 1 and 3.
J N, Hatwell, P M, Sharp
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Infection with polyomavirus JC
BMJ, 2011Is highly prevalent, and can be fatal in immunocompromised people The recent discovery of new neurological syndromes that result from neuronal infection with polyomavirus JC, also known as JC virus, and the presence of this virus in the grey matter are currently under debate.1 It has been suggested that JC virus is associated with cognitive decline ...
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JC polyomavirus in the aetiology and pathophysiology of glial tumours
Neurosurgical Review, 2015Glial brain tumours with their poor prognosis, limited treatment modalities and unclear detailed pathophysiology represent a significant health concern. The purpose of the current study was to investigate and describe the possible role of the human polyomavirus JC as an underlying cancerogenic or co-cancerogenic factor in the complex processes of glial
Tihomir, Eftimov +5 more
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Human Polyomavirus JC and Progressive Multifocal Leukoencephalopathy
2013John Cunningham virus (JCV) is a double-stranded DNA polyomavirus isolated in 1971 by Padgett et al. from the brain of a patient with Hodgkin disease. Viral DNA is transcripted on both strands and it encodes for the early genes counterclockwise and for the late genes clockwise.
MISCHITELLI, MONICA +5 more
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Characterization of JC human polyomavirus infection in a Portuguese population
Journal of Medical Virology, 2010AbstractJC virus (JCV) is ubiquitous in the human population, infecting children asymptomatically. After primary infection, JCV persists in the host throughout life and is often excreted in the urine. Two hundred thirty‐four urine samples and 78 serum samples, collected from 171 healthy individuals and 63 patients infected with HIV, were used to ...
Ana, Matos +5 more
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Haemorrhagic cystitis and polyomavirus JC infection in ataxia telangiectasia
Journal of Pediatric Urology, 2009We report the case of a young adolescent with ataxia telangiectasia (AT) and life-threatening haemorrhage from the bladder due to a combination of bladder wall telangiectasis, immunosuppressive therapy and an infection with polyomavirus JC. BK and JC are both members of the polyomavirus family. BK virus is a known cause of haemorrhagic cystitis in bone-
Martin, Christmann +5 more
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Immunosuppression increases latent infection of brain by JC polyomavirus
Pathology, 2011Progressive multifocal leukoencephalopathy (PML) is caused by reactivation of JC polyomavirus (JCV). Increased JCV reactivation in kidney, as indicated by JCV viruria is reported during immunosuppression; however, the relevance of systemic to neural reactivation remains unknown.Brain and kidney tissue from 138 non-PML patients (78 immunocompetent; 60 ...
Julianne, Bayliss +4 more
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Kidney graft loss associated with JC polyomavirus nephropathy
Journal of Nephrology, 2009Abstract This is the first case of documented treatment failure of JCV nephritis, despite a reduction of immunosuppressive agents and the use of antiviral therapy. We consistently detected high levels of JCV viremia, which correlated with the progressive deterioration of the graft and caused the final loss of the kidney, suggesting ...
Davide, Rolla +5 more
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Human Polyomavirus JC and BK Persistent Infection
2007Primary contact with the human polyomaviruses (HPV) is followed by lifelong persistence of viral DNA in its host. The most prominent organs affected are the kidney, the Central Nervous System (CNS)and the hematopoietic system. Under impairment of immune competence limited activation of virus infection can be followed by prolonged virus multiplication ...
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