Results 141 to 150 of about 65,024 (264)

Could a macular telangiectasia type 2-like phenotype characterize retinal JC virus infection? [PDF]

AIDS
Varenne F, Siegfried-Vergnon A, Lhomme S, Treiner E, Pignolet B, Joly M, Bonneville F, Gandia P, Rodriguez C, Cortese I, Martin-Blondel G, Soler V.   +11 more
europepmc   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Molecular characterization of JC virus in progressive multifocal leukoencephalopathy cases from India. [PDF]

Sci Rep
Palani GS, Telang S, Reddy V, Dhanya K, Ashwini MA, Mani RS.   +5 more
europepmc   +1 more source

Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease. [PDF]

Nat Rev Neurol, 2021
Cortese I, Reich DS, Nath A.
europepmc   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Should natalizumab be used despite JC virus positivity?-Commentary. [PDF]

Mult Scler
Hedström AK.
europepmc   +1 more source

Adoptive Transfer of JC Virus-Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy. [PDF]

Ann Neurol, 2021
Berzero G, Basso S, Stoppini L, Palermo A, Pichiecchio A, Paoletti M, Lucev F, Gerevini S, Rossi A, Vegezzi E, Diamanti L, Bini P, Gastaldi M, Delbue S, Perotti C, Seminari E, Faraci M, Luppi M, Baldanti F, Zecca M, Marchioni E, Comoli P.   +21 more
europepmc   +1 more source

Ageing‐Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1‐Meditated Ca2+ Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice

Cell Proliferation, EarlyView.
During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi, Yusheng Zhang, Gong Chen, Jiru Zhang, Jing Liu, Hao Zhu, Minne Sun, Yu Duan   +7 more
wiley   +1 more source

Persistence of intraocular JC-virus associated with a MacTel phenotype. [PDF]

AIDS
Hupin N, Hoogewoud F, Sallo FB, Vermeirsch S, Suttels V, Guex-Crosier Y.   +5 more
europepmc   +1 more source

Central nervous system disease with JC virus infection in adults with congenital HIV. [PDF]

AIDS, 2021
McEntire CRS, Fong KT, Jia DT, Cooper ER, Cervantes-Arslanian AM, Mateen FJ, Anand P, Thakur KT.   +7 more
europepmc   +1 more source