JNK and p38 gene and protein expression during liver ischemia-reperfusion in a rat model treated with silibinin [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Signal transduction of mitogen-activated protein kinases (MAPKs) is activated during ischemia. In this study, c-Jun N-terminal Kinase (JNK) and p38 MAPK (p38) gene and protein expression were evaluated as two members of the MAPK family ...
Nastaran Aamani +4 more
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Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity. [PDF]
, 2014 BackgroundMounting evidence points to individual contributions of tumour necrosis factor-alpha (TNF) and the c-Jun N-terminal kinase (JNK) pathway to the induction and maintenance of various pain states.
Abdelmoaty, S +8 more
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Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model
Frontiers in Cell and Developmental Biology, 2020 The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has many functions, regulating a diversity of processes: from cell movement during embryogenesis to the stress response of cells after environmental insults.
John E. La Marca, H. Richardson
semanticscholar +1 more source
c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]
, 2012 The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
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The role of JNK in the proinflammatory action of the SARS-CoV-2 protein ORF3a [PDF]
Medicinski PodmladakIntroduction: Coronavirus disease 2019 (COVID-19) is a contagious respiratory infection caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Aranđelović Lena +4 more
doaj +1 more source
Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. [PDF]
, 2007 c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7,
Boyle, David L +3 more
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Circulation Research, 2002 Large numbers of gap junctions interconnect working myocytes in the ventricle of adult humans.1–5⇓⇓⇓⇓ Until recently, it was assumed that the reason for the abundance of these clusters of intercellular channels was straightforward. This phenomenon was thought to be principally a matter of ensuring that action potentials were conducted efficiently from ...
Ralph J. Barker, Robert G. Gourdie
openaire +1 more source
SFRP1 suppresses granulosa cell proliferation and migration through inhibiting JNK pathway
Clinical and Experimental Obstetrics & Gynecology, 2021 Background: Secreted frizzled-related protein 1 (SFRP1) functions as a Wnt antagonist to repress the proliferation and migration of epithelial ovarian cancer cells.
Shan Zhou, Liang Xia, Liyuan Han
doaj +1 more source
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]
, 2014 Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre +67 more
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Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor treated CML stem cells [PDF]
, 2016 Treatment of chronic myelogenous leukemia (CML) with BCR-ABL tyrosine kinase inhibitors (TKI) fails to eliminate leukemia stem cells (LSC). Patients remain at risk for relapse, and additional approaches to deplete CML LSC are needed to enhance the ...
Agarwal, Puneet +9 more
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