Activation of the Sap-1a Transcription Factor by the c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase [PDF]
Journal of Biological Chemistry, 1997 Ternary complex factors (TCFs) bind to the serum response element in the c-fos promoter and mediate its activation by many extracellular stimuli. Some of these stimuli activate the ERK subclass of mitogen-activated protein kinases (MAPKs) that target the TCF Sap-1a.
Ralf Janknecht, Tony Hunter
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Vomitoxin-Induced Cyclooxygenase-2 Gene Expression in Macrophages Mediated by Activation of ERK and p38 but Not JNK Mitogen-Activated Protein Kinases [PDF]
Toxicological Sciences, 2002 Vomitoxin (VT) and other trichothecene mycotoxins mediate a broad range of immunotoxic effects via the induction of inflammation-associated genes in leukocytes. The purpose of this study was to test the hypothesis that VT induces cyclooxygenase-2 (COX-2)
Yuseok Moon, James J. Pestka
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Activation of G1 Progression, JNK Mitogen-activated Protein Kinase, and Actin Filament Assembly by the Exchange Factor FGD1 [PDF]
Journal of Biological Chemistry, 1998 Cdc42 has been shown to control bifurcating pathways leading to filopodia formation/G1 cell cycle progression and to JNK mitogen-activated protein kinase activation. To dissect these pathways further, the cellular effects induced by a Cdc42 guanine nucleotide exchange factor, FGD1, have been examined.
Koh‐ichi Nagata +4 more
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Scaffold Role of a Mitogen-activated Protein Kinase Phosphatase, SKRP1, for the JNK Signaling Pathway [PDF]
Journal of Biological Chemistry, 2002 Stress-activated protein kinase (SAPK) pathway-regulating phosphatase 1 (SKRP1) has been identified as a member of the mitogen-activated protein kinase (MAPK) phosphatase (MKP) family that interacts physically with the MAPK kinase (MAPKK) MKK7, a c-Jun N-terminal kinase (JNK) activator, and inactivates the MAPK JNK pathway.
Takeru Zama +5 more
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Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity [PDF]
Carcinogenesis, 2000 In this study we have explored the involvement of oxidative stress in Cr(VI)-induced JNK, p38 and ERK signaling pathways and their effects on Cr(VI) cytotoxicity in human non-small cell lung carcinoma CL3 cells.
Show‐Mei Chuang +2 more
semanticscholar +3 more sources
Drosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif. [PDF]
PLoS ONE, 2012 Defining context specific requirements for proteins and pathways is a major challenge in the study of signal transduction. For example, the stress-activated protein kinase (SAPK) pathways are comprised of families of closely related transducers that are ...
Rebecca L Gonda +2 more
doaj +11 more sources
Ultraviolet Light-induced Stimulation of the JNK Mitogen-activated Protein Kinase in the Absence of Src Family Tyrosine Kinase Activation [PDF]
Journal of Biological Chemistry, 2000 In T cells, the JNK mitogen-activated protein kinase is activated by simultaneous stimulation of the T-cell receptor and CD28 or by a number of stress stimuli including ultraviolet light, hydrogen peroxide, and anisomycin. Lck, a Src family kinase, is essential for T-cell receptor-mediated activation of JNK.
Kambiz Amdjadi, Bartholomew M. Sefton
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Activation of the cellular mitogen-activated protein kinase pathways ERK, P38 and JNK duringToxoplasma gondiiinvasion [PDF]
Parasite, 2003 Host cell invasion is essential for the pathogenicity of the obligate intracellular protozoan parasite Toxoplasma gondii. In the present study, we evaluated the ability of T. gondii tachyzoites to trigger phosphorylation of the different mitogen-activated protein kinases (MAPK) in human monocytic cells THP1.
Audrey Valere +5 more
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JNK and p38 Mitogen-Activated Protein Kinase Pathways Contribute to Porcine Circovirus Type 2 Infection [PDF]
Journal of Virology, 2009 ABSTRACTInfection with a wide variety of viruses often perturbs host cell signaling pathways including the Jun NH2-terminal kinase/stress-activated kinase (JNK/SAPK) and the p38 mitogen-activated protein kinase (p38/MAPK), which are important components of cellular signal transduction pathways.
Li Wei, Zhongwu Zhu, Jing Wang, Jue Liu
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The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases [PDF]
BMC Genomics, 2011 Abstract Background Anopheles gambiae is the primary mosquito vector of human malaria parasites in sub-Saharan Africa. To date, three innate immune signaling pathways, including the nuclear factor (NF)-kappaB-dependent Toll and immune deficient (IMD) pathways and the Janus kinase/signal transducers and ...
Ashley A Horton +8 more
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