Results 91 to 100 of about 2,887,251 (356)

Work-Family Conflict and Job Satisfaction: the Mediating Role of Person-Organization Fit Study on Employees of the BRI Aceh Region [PDF]

open access: yes, 2016
The objective of this research is to analyze the influence of person–organizationfit (P-O fit) on work–family conflict (WFC) and job satisfaction (JS) relationships atBank Rakyat Indonesia, Aceh Regional in Banda Aceh.
Ibrahim, M. (Mahdani), Yusra, Y. (Yusra)
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Talent Flow Analytics in Online Professional Network

open access: yesData Science and Engineering, 2018
Analyzing job hopping behavior is important for understanding job preference and career progression of working individuals. When analyzed at the workforce population level, job hop analysis helps to gain insights of talent flow among different jobs and ...
Richard J. Oentaryo   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Scheduling with Predictions and the Price of Misprediction [PDF]

open access: yes, 2019
In many traditional job scheduling settings, it is assumed that one knows the time it will take for a job to complete service. In such cases, strategies such as shortest job first can be used to improve performance in terms of measures such as the ...
Mitzenmacher, Michael
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Workload Analysis to Determine the Optimal Number of Human Resources at Sariraya Co., Ltd

open access: yesIndonesian Interdisciplinary Journal of Sharia Economics
Sariraya Co., Ltd is a pioneer Indonesian halal food chain based in Aichi, Japan. Sariraya specializes in halal food chains in Japan with several business units such as tempeh factories, restaurants, and halal marts.
Fauzan Nafisa Faryaputra, Kiki Sudiana
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

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