Results 41 to 50 of about 11,386,708 (226)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Understanding the Contribution of HRM Bundles for Employee Outcomes Across the Life-Span

Frontiers in Psychology, 2019
Using the Job Demands-Resources model literature and the life-span theory as scholarly frameworks, we examined the effects of job demands and job resources as mediators in the relationship between bundles of used HRM practices and employee outcomes.
Klaske N. Veth, Klaske N. Veth, Hubert P. L. M. Korzilius, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Ben J. M. Emans, Annet H. De Lange, Annet H. De Lange   +10 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Service-oriented job crafting for employee well-being in hotel industry: a job demands-resources perspective

Cogent Business & Management
The hotel industry, recognizing the critical need to understand the dynamics between job demands, job resources, service-oriented job crafting and employee well-being, investigates this interplay utilizing the Job-Demands-Resources (JD-R) theory as its ...
Yustisia Kristiana, Rosdiana Sijabat, Niko Sudibjo, Innocentius Bernarto   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Recovery needs of emotional labor - A resource perspective on job demands in major Vietnamese cities

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kinh tế và Quản trị kinh doanh
This research investigates emotional labor within workplace environments characterized by emotional management demands that potentially exacerbate employee stress and fatigue.
Nguyễn Hồng Quân, Nguyễn Yến Nhi, Nguyễn Vân Nhi, Phùng Minh Khôi   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Reciprocal relationships between job demands, job resources, and recovery opportunities

, 2012
The aim of this study was to explore longitudinal relationships between job demands, job resources, and recovery opportunities. On the basis of the Job Demands-Resources model and Conservation of Resources theory we hypothesized that we would find ...
Rodríguez-Muñoz, A. (Alfredo), Sanz-Vergel, A.I. (Ana Isabel), Demerouti, E. (Eva), Bakker, A.B. (Arnold)   +3 more
core   +2 more sources

Job demands-resources on digital gig platforms and counterproductive work behavior

Frontiers in Psychology
IntroductionWith the rapid expansion of digital gig platforms, counterproductive work behavior among gig workers has become increasingly prominent, adversely impacting the platform’s reputation, operational efficiency, and user experience.
Shanshan Zhao, Shanshan Zhao, Yanfeng Liu, Yanfeng Liu   +3 more
doaj   +1 more source