Results 111 to 120 of about 1,243,353 (299)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Affective organizational commitment among nursing home employees: A longitudinal study on the influence of a health‐promoting work environment

open access: yesNursing Open, 2019
Aim To investigate whether affective organizational commitment (AOC) among nursing home employees is enhanced by a health‐promoting work environment, conceptualized as high levels of job resources, work‐related sense of coherence (work‐SOC) and low ...
Karoline Grødal   +3 more
doaj   +1 more source

New Estimates of Disability-Related Wage Discrimination with Controls for Job Demands [PDF]

open access: yes
Using data from 2004 SIPP, matched to job demands from O*Net, we provide new estimates of disability-related wage discrimination. We apply state-of-the-art econometric methods to wage models which include job demands and interactions between demands and ...
BALDWIN Marjorie L., CHOE Chung
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Job Demand or Resource?

open access: yesZeitschrift für Arbeits- und Organisationspsychologie A&O
Abstract: Artificial intelligence (AI) can function both as a job demand and as a job resource, with crucial implications for employees’ well-being and motivation. However, research has not yet investigated how employees appraise AI in these terms and whether their appraisals are malleable.
Franziska Schrade   +2 more
openaire   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

open access: yesAging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath   +3 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Managing Vitality, Sustainable Performance and Fatigue in Nursing Home Staff: A Multi‐Location Cross‐Sectional Survey Study: Empirical Research Quantitative

open access: yesNursing Open
Aim This study examines the moderating role of specific job resources in the association between job demands, vigour, sustainable performance and fatigue in nursing home staff.
Jan deJonge   +2 more
doaj   +1 more source

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