Results 101 to 110 of about 1,863,226 (298)

Aspirations and job burnout: A study of New Zealand managers [PDF]

open access: yes, 2011
Self Determination Theory (SDT) asserts aspirations (life goals) of personal growth, relationship, community and health (intrinsic aspirations) support optimal functioning including in employees and leaders, whereas aspirations for wealth, image and fame
Haar, Jarrod, Roche, Maree
core   +1 more source

The impact of workload and emotional demands on turnover intentions: the mediating and moderating effects of job burnout

open access: yesFrontiers in Psychology
IntroductionAlthough workload and emotional demands are recognized as key antecedents of job burnout, research focusing on preschool teachers has rarely compared their relative effects or explored whether burnout may function simultaneously as a mediator
Wen-Yu Hung   +2 more
doaj   +1 more source

Job Demand or Resource?

open access: yesZeitschrift für Arbeits- und Organisationspsychologie A&O
Abstract: Artificial intelligence (AI) can function both as a job demand and as a job resource, with crucial implications for employees’ well-being and motivation. However, research has not yet investigated how employees appraise AI in these terms and whether their appraisals are malleable.
Franziska Schrade   +2 more
openaire   +1 more source

The Impact Of Job Demands And Resources On Job Crafting

open access: yesJournal of Applied Business Research (JABR), 2017
Organizations are constantly under pressure for survival in the current highly volatile work environment. This change has been accelerated by trends such as smart work environments and artificial intelligence in the organizational context. Given such uncertainty deriving from a fast rate of change and high complexity, it is vital for organizations to ...
Sang-Hoon Lee   +2 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Putting Tasks to the Test: Human Capital, Job Tasks and Wages [PDF]

open access: yes
Employing original, representative survey data, we document that cognitive, interpersonal and physical job task demands can be measured with high validity using standard interview techniques.
David H. Autor, Michael J. Handel
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Affective organizational commitment among nursing home employees: A longitudinal study on the influence of a health‐promoting work environment

open access: yesNursing Open, 2019
Aim To investigate whether affective organizational commitment (AOC) among nursing home employees is enhanced by a health‐promoting work environment, conceptualized as high levels of job resources, work‐related sense of coherence (work‐SOC) and low ...
Karoline Grødal   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

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