Results 101 to 110 of about 20,657 (229)

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, EarlyView.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source

EGFR signaling confers resistance to BET inhibition in hepatocellular carcinoma through stabilizing oncogenic MYC

Journal of Experimental & Clinical Cancer Research, 2019
Background The bromodomain and extra-terminal domain (BET) inhibitor is a type of anti-tumor agent, currently being evaluated in phase I and II clinical trials for cancer therapy.
Yalei Yin, Mingju Sun, Xi Zhan, Changqing Wu, Pengyu Geng, Xiaoyan Sun, Yunsong Wu, Shuijun Zhang, Jianhua Qin, Zhengping Zhuang, Yang Liu   +10 more
doaj   +1 more source

Blocking the Bromodomains Function Contributes to Disturbances in Alga Chara vulgaris Spermatids Differentiation

Cells, 2020
Bromodomain containing (BRD) proteins play an essential role in many cellular processes. The aim of this study was to estimate activity of bromodomains during alga Chara vulgaris spermatids differentiation. The effect of a bromodomain inhibitor, JQ1 (100
Agnieszka Wojtczak
doaj   +1 more source

Integrability and action operators in quantum Hamiltonian systems [PDF]

, 2000
For a (classically) integrable quantum mechanical system with two degrees of freedom, the functional dependence $\hat{H}=H_Q(\hat{J}_1,\hat{J}_2)$ of the Hamiltonian operator on the action operators is analyzed and compared with the corresponding ...
E. Magyari, Gerhard Müller, H. J. Stöckman, I. C. Percival, J. Spanier, L. E. Reichl, M. B. Cibils, M. B. Cibils, M. C. Gutzwiller, M. C. Gutzwiller, N. Srivastava, S. Ree, S. Weigert, V. V. Stepanov, V. V. Stepanov, Vyacheslav V. Stepanov   +15 more
core   +4 more sources

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells

Cell Death and Disease, 2019
(+)-JQ1 is an inhibitor of the tumor-driver bromodomain protein BRD4 and produces satisfactory effects because it efficiently increases apoptosis. Ferroptosis is an oxidative cell death program differing from apoptosis.
Shiyao Sui, Jian Zhang, Shouping Xu, Qin Wang, Peiyuan Wang, D. Pang   +5 more
semanticscholar   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

iRGD Tumor-Penetrating Peptide-Modified Nano-Delivery System Based on a Marine Sulfated Polysaccharide for Enhanced Anti-Tumor Efficiency Against Breast Cancer

International Journal of Nanomedicine, 2022
Bowei Chen,1,* Xiaohong Liu,1,* Yunan Li,1 Tianhe Shan,1 Liya Bai,1 Chunyu Li,2 Yinsong Wang1 1School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin ...
Chen B, Liu X, Li Y, Shan T, Bai L, Li C, Wang Y   +6 more
doaj  

BET protein inhibitor JQ1 downregulates chromatin accessibility and suppresses metastasis of gastric cancer via inactivating RUNX2/NID1 signaling

Oncogenesis, 2020
Chromatin accessibility is critical for tumor development, whose mechanisms remain unclear. As a crucial regulator for chromatin remodeling, BRD4 promotes tumor progression by regulating multiple genes.
Siqi Zhou, Shu Zhang, Lei Wang, Shu-ling Huang, Yue Yuan, Jie Yang, Hui Wang, Xihan Li, Pin Wang, Lin Zhou, Jun Yang, Yuemei Xu, Huan Gao, Yixuan Zhang, Ying Lv, X. Zou   +15 more
semanticscholar   +1 more source

Bromodomain‐containing protein 4 inhibitor JQ1 promotes melanoma cell apoptosis by regulating mitochondrial dynamics

Cancer Science, 2021
Although the role of bromodomain‐containing protein 4 (BRD4) in ovarian cancer, pancreatic cancer, lymphoma, and many other diseases is well known, its function in cutaneous melanoma is only partially understood.
Liyuan Li, Yan Meng, Xiaolin Wu, Jiajing Li, Yuxin Sun   +4 more
semanticscholar   +1 more source

Inhibiting STAT5 by the BET Bromodomain Inhibitor JQ1 Disrupts Human Dendritic Cell Maturation [PDF]

The Journal of Immunology, 2015
Abstract Maturation of dendritic cells (DCs) is required to induce T cell immunity, whereas immature DCs can induce immune tolerance. Although the transcription factor STAT5 is suggested to participate in DC maturation, its role in this process remains unclear.
Patricia A, Toniolo, Suhu, Liu, Jennifer E, Yeh, Pedro M, Moraes-Vieira, Sarah R, Walker, Vida, Vafaizadeh, José Alexandre M, Barbuto, David A, Frank   +7 more
openaire   +2 more sources