Results 131 to 140 of about 20,657 (229)
Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc
eLife, 2015 The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by replicating selected results from a substantial number of high-profile papers in the field of cancer biology published between ...
Irawati Kandela +3 more
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BMC Cancer, 2018 Background Targeted therapy has always been the focus in developing therapeutic approaches in cancer, especially in the treatment of acute myeloid leukemia (AML).
Yafeng Zhou +4 more
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A methodology for the decomposition of discrete event models for parallel simulation [PDF]
, 1993 Parallel simulation has presented the possibility of performing high-speed simulation. However, when attempting to make a link between the requirements of parallel simulation and discrete event simulation used in commercial areas such as manufacturing, a
Taylor, S J E, Wilson, D R, Winter, S C
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On the constant in the Mertens product for arithmetic progressions. II. Numerical values
, 2007 We give explicit numerical values with 100 decimal digits for the constant in the Mertens product over primes in the arithmetic progressions $a \bmod q$, for $q \in \{3$, ..., $100\}$ and $(a, q) = 1$.Comment: The complete set of results can be ...
Languasco, A., Zaccagnini, A.
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Cancer Management and Research, 2020 Songwei Huan,1,* Tao Gui,1,* Qiutong Xu,1,* Songkuan Zhuang,2 Zhenyan Li,1 Yuling Shi,3 Jiebin Lin,3 Bin Gong,1 Guiqiang Miao,1 Manseng Tam,4 Huan-Tian Zhang,1 Zhengang Zha,1 Chunfei Wu3 1Institute of Orthopedic Diseases and Department of Bone and Joint ...
Huan S +12 more
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EBioMedicine, 2019 Background: DNA repair deficiency accumulates DNA damage and sensitizes tumor cells to PARP inhibitors (PARPi). Based on our observation that the BET inhibitor JQ1 increases levels of DNA damage, we evaluated the efficacy of JQ1 + the PARPi olaparib in ...
Aubrey L. Miller +8 more
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Finite order automorphisms and real forms of affine Kac-Moody algebras in the smooth and algebraic category [PDF]
, 2009 Automorphisms of finite order and real forms of "smooth" affine Kac-Moody algebras are studied, i.e. of 2-dimensional extensions of the algebra of smooth loops in a simple Lie algebra.
Groß, Christian, Heintze, Ernst
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Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
Journal for ImmunoTherapy of Cancer, 2019 Background Prostate cancer responds poorly to current immunotherapies. Epigenetic therapies such as BET Bromodomain inhibition can change the transcriptome of tumor cells, possibly making them more immunogenic and thus susceptible to immune targeting ...
Wendy Mao +8 more
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Sinteza i biološko profilisanje (+)-JQ1 amida kao BET inhibitora
, 2021 BET proteini su epigenetski biološki targeti koji regulišu ekspresiju gena i uključeni su u patogenezu kancera. Jedan od inhibitora ovih proteina koji je opisan u literaturi je derivat tienotriazolodiazepina (+)-JQ1. Cilj ovog rada bio je dalje unapređenje osobina (+)-JQ1 derivatizacijom estarske grupe (Shema 1). U toku ovog istraživanja sintetisano je
Koravović, Mladen +6 more
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Polydopamine-Based Nanoparticles for Synergistic Chemotherapy of Prostate Cancer
International Journal of NanomedicineKebang Hu,1 Dongqi Zhang,1 Weiran Ma,2 Yanzhi Gu,2 Jiang Zhao,3 Xupeng Mu4 1Department of Urology, Lequn Branch, The First Hospital of Jilin University, Changchun, 130031, People’s Republic of China; 2College of Pharmacy, Jilin University, Changchun ...
Hu K, Zhang D, Ma W, Gu Y, Zhao J, Mu X
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