Results 11 to 20 of about 20,657 (229)
(+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling [PDF]
Cell & Bioscience, 2018 Background Microglia activation is a crucial event in neurodegenerative disease. The depression of microglial inflammatory response is considered a promising therapeutic strategy.
Huanhuan Wang +12 more
doaj +3 more sources
Bromodomain Inhibitor JQ1 Provides Novel Insights and Perspectives in Rhabdomyosarcoma Treatment
International Journal of Molecular Sciences, 2022 Rhabdomyosarcoma (RMS) is the most common type of pediatric soft tissue sarcoma. It is classified into two main subtypes: embryonal (eRMS) and alveolar (aRMS).
I. Marchesi +6 more
semanticscholar +3 more sources
Modulation of Virulence-Associated Traits in Aspergillus fumigatus by BET Inhibitor JQ1
Microorganisms, 2022 Aspergillus fumigatus is a disease-causing, opportunistic fungus that can establish infection due to its capacity to respond to a wide range of environmental conditions.
Anastasia Orekhova +12 more
doaj +5 more sources
The bromodomain inhibitor JQ1 is a molecular glue targeting centromeres
bioRxiv, 2023 Centromeres are the position on each chromosome that orchestrates the accurate partitioning of the genome during cell division. Centromere-dependent cell-cycle checkpoints are maintained by cancer cells to prevent catastrophic chromosome segregation ...
S. Corless +8 more
semanticscholar +2 more sources
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE. [PDF]
Brain Research Bulletin, 2022 Sepsis-associated encephalopathy (SAE) manifests clinically in hyperneuroinflammation. Pyroptosis, which can induce an inflammatory cascade response, has been considered to be a causative factor of SAE.
Xiao-Juan Zhong +8 more
semanticscholar +3 more sources
Co-Encapsulation of Paclitaxel and JQ1 in Zein Nanoparticles as Potential Innovative Nanomedicine
Micromachines, 2022 The manuscript describes the development of zein nanoparticles containing paclitaxel (PTX) and the bromo-and extra-terminal domain inhibitor (S)-tertbutyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-6-yl ...
M. Celano +7 more
semanticscholar +4 more sources
Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)‐JQ1 [PDF]
Helvetica Chimica Acta, 2021 AbstractA series of bulky organometallic and organic analogues of the bromodomain (BRD) inhibitor (+)‐JQ1 have been prepared. The most potent, N‐[(adamantan‐1‐yl)methyl]‐2‐[(9S)‐7‐(4‐chlorophenyl)‐4,5,13‐trimethyl‐3‐thia‐1,8,11,12‐tetraazatricyclo[8.3.0.02,6]trideca‐2(6),4,7,10,12‐pentaen‐9‐yl]acetamide, 2e, showed excellent potency with an KD=ca.
Hassell‐Hart, Storm +14 more
openaire +4 more sources
Neoplasia: An International Journal for Oncology Research, 2022 BH3 mimetics are promising novel anticancer therapeutics. By selectively inhibiting BCL-2, BCL-xL, or MCL-1 (i.e. ABT-199, A-1331852, S63845) they shift the balance of pro- and anti-apoptotic proteins in favor of apoptosis.
Ufuk Erdogdu +7 more
doaj +1 more source
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
Tissue Engineering and Regenerative Medicine, 2021 Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy.
Seok-hyeong Go +5 more
semanticscholar +3 more sources
Genes and Diseases, 2022 As a BET bromodomain inhibitor, JQ1 has been proven have efficacy against a number of different cancers. In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice could lead to germ cell defects and a
Xiaorong Wang +11 more
doaj +1 more source