Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE) [PDF]
Molecular and Cellular Pediatrics, 2023 Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE).
Valentina Natoli +3 more
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Bone mineral density in juvenile systemic lupus erythematosus [PDF]
Brazilian Journal of Medical and Biological Research, 2002 We evaluated spine bone mineral density (BMD) in Brazilian children with juvenile systemic lupus erythematosus (JSLE) in order to detect potential predictors of reduction in bone mass.
Castro T.C.M. +6 more
doaj +2 more sources
Ovarian dysfunction in adolescent girls with autoimmune rheumatic diseases [PDF]
Pediatric Rheumatology Online Journal, 2023 Objective To explore the different menstrual and pubertal abnormalities in adolescent females with systemic autoimmune rheumatic diseases (ARD). Methods The study included adolescent girls aged 13–18 years with juvenile idiopathic arthritis (JIA ...
Mohamed Taman +3 more
doaj +2 more sources
Desempenho diagnóstico e associações clínicas dos anticorpos contra componentes da cromatina no lúpus eritematoso sistêmico juvenil Diagnostic performance and clinical associations of antibodies to the chromatin antigenic system in juvenile systemic lupus erythematosus [PDF]
Revista Brasileira de Reumatologia, 2012 OBJETIVOS: Determinar a frequência de anticorpos contra componentes da cromatina no lúpus eritematoso sistêmico juvenil (LESJ) e correlacionar a presença desses autoanticorpos com manifestações clínicas e atividade da doença.
Silene Peres Keusseyan +5 more
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Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus [PDF]
Brazilian Journal of Medical and Biological Research, 2014 We evaluated the concentrations of 25-hydroxyvitamin D [25(OH)D] in children and adolescents with juvenile systemic lupus erythematosus (JSLE) and associated them with disease duration and activity, use of medication (chloroquine and glucocorticoids ...
O.A.B. Peracchi +6 more
doaj +5 more sources
Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement [PDF]
Frontiers in ImmunologyBackgroundLupus pathogenesis is mainly ascribed to increased production and/or impaired clearance of dead cell debris. Although self-reactive T and B lymphocytes are critically linked to lupus development, neutrophils, monocytes, and natural killer (NK ...
Bernadete L. Liphaus +7 more
doaj +2 more sources
Interplay of NF-κB and PPAR-γ transcription factors in patients with juvenile systemic lupus erythematosus [PDF]
Lupus Science and MedicineObjective Juvenile SLE (jSLE) is an autoimmune disease characterised by the presence of high levels of autoantibodies, predominantly targeting nuclear antigens, resulting in a breakdown of self-tolerance.
Ozgur Kasapcopur +6 more
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Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus [PDF]
Frontiers in MedicineBackground and aimsJuvenile-onset systemic lupus erythematosus (JSLE) is a chronic autoimmune disease affecting individuals under 18, causing multi-system impairment.
Su Jin Park +2 more
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Lymphocyte apoptosis and its association with the inflammatory markers and disease severity in juvenile-onset systemic lupus erythematosus patients [PDF]
Pediatric Rheumatology Online JournalBackground The defective clearance of apoptotic bodies in juvenile-onset systemic lupus erythematosus (jSLE) potentially leads to the persistence of autoreactive lymphocytes and the perpetuation of the autoimmune response. These factors contribute to the
Eman Eissa +4 more
doaj +2 more sources
An Unprecedented Triad: Simultaneous Acute Pancreatitis, Axonal Polyneuropathy, and Type 1 Diabetes Mellitus in a Catastrophic Juvenile Lupus Flare [PDF]
Clinical Case ReportsA 14‐year‐old female with juvenile systemic lupus erythematosus (jSLE) presented with a life‐threatening and previously unreported triad: the simultaneous onset of acute pancreatitis, severe axonal polyneuropathy, and autoimmune Type 1 Diabetes (T1D ...
Laiba Hashmi +11 more
doaj +2 more sources