Results 41 to 50 of about 98,997 (145)

Proteomic analysis of a novel Bacillus Jumbo phage revealing glycoside hydrolase as structural component [PDF]

Frontiers in Microbiology, 2016
Tailed phages with genomes of larger than 200 kbp are classified as Jumbo phages and exhibited extremely high uncharted diversity. The genomic annotation of Jumbo phage is often disappointing because most of the predicted proteins, including structural ...
Yihui eYuan, Meiying eGao
doaj   +3 more sources

Conserved jumbo phage factors required for protein import into a phage nucleus

bioRxiv
Bacteriophages use diverse mechanisms to evade anti-phage defenses systems. ΦKZ-like jumbo phages assemble a proteinaceous nucleus-like compartment that excludes antagonistic host nucleases, while internalizing DNA replication and transcription ...
Claire Kokontis, T. Klein, Sukrit Silas, Joseph Bondy-Denomy   +3 more
semanticscholar   +2 more sources

Isolation and Characterization of a Novel Jumbo Phage HPP-Temi Infecting Pseudomonas aeruginosa Pa9 and Increasing Host Sensitivity to Ciprofloxacin [PDF]

Antibiotics
Pseudomonas aeruginosa is a bacteria responsible for many hospital-acquired infections. Phages are promising alternatives for treating P. aeruginosa infections, which are often intrinsically resistant. The combination of phage and antibiotics in clearing
Olufunke Olufunmilola Olorundare, Nikita Zrelovs, Dennis Kabantiyok, Karina Svanberga, Juris Jansons, Andris Kazaks, Godwin Ojonugwa Agada, Chibuzor Gerald Agu, Oluwatoyin Ruth Morenikeji, Ogundeji Alice Oluwapelumi, Thomas Dung, Shedrach Benjamin Pewan   +11 more
doaj   +2 more sources

Antivirulence Activity and Therapeutic Potential of Jumbo <i>Vibrio</i> Phage pVa-22 against <i>Vibrio alginolyticus</i>. [PDF]

J Microbiol Biotechnol
Vibrio alginolyticus is an emerging zoonotic pathogen responsible for severe aquaculture and human infections, and its increasing antimicrobial resistance calls for alternative control strategies. Here, we report the isolation and characterization of the
Jo SJ, Kwon J, Park SC, Kim SG.
europepmc   +2 more sources

Larger Than Life: Isolation and Genomic Characterization of a Jumbo Phage That Infects the Bacterial Plant Pathogen, Agrobacterium tumefaciens. [PDF]

Front Microbiol, 2018
Agrobacterium tumefaciens is a plant pathogen that causes crown gall disease, leading to the damage of agriculturally-important crops. As part of an effort to discover new phages that can potentially be used as biocontrol agents to prevent crown gall ...
Attai H, Boon M, Phillips K, Noben JP, Lavigne R, Brown PJB.   +5 more
europepmc   +2 more sources

Therapeutic application of a jumbo bacteriophage against metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates [PDF]

Journal of Biomedical Science
Background Therapeutic options against metallo-β-lactamase producing P. aeruginosa (MBL-PA) are limited due to multi-drug resistance. A jumbo phage isolated from wastewater in Greece was characterized microbiologically and genetically and evaluated for ...
Paschalis Paranos, Dimitrios Skliros, Nikita Zrelovs, Panagiota-Christina Georgiou, Karina Svanberga, Andris Kazaks, Marios Kostakis, Nikolaos Thomaidis, Emmanouil Flemetakis, Joseph Meletiadis   +9 more
doaj   +2 more sources

Xanthomonas citri jumbo phage XacN1 exhibits a wide host range and high complement of tRNA genes. [PDF]

Sci Rep, 2018
Xanthomonas virus (phage) XacN1 is a novel jumbo myovirus infecting Xanthomonas citri, the causative agent of Asian citrus canker. Its linear 384,670 bp double-stranded DNA genome encodes 592 proteins and presents the longest (66 kbp) direct terminal ...
Yoshikawa G, Askora A, Blanc-Mathieu R, Kawasaki T, Li Y, Nakano M, Ogata H, Yamada T.   +7 more
europepmc   +2 more sources

Unexplored diversity and molecular genetic signatures of chimallin and phuz encoding phages [PDF]

BMC Genomics
Nucleus-forming phages are a class of jumbo phages with the capacity to form a protein nuclear shell during infection within a bacterial host. This protein nuclear shell protects the replication of the phage genome by excluding host defense factors ...
Shize Sun, Cunyuan Li, Jia Sun, Xiaoyue Li, Min Liu, Xia Li, Kaiping Liu, Hui Li, Jinming Yu, Ping Zhou, Limin Wang, Kuojun Cai, Wei Ni, Shengwei Hu   +13 more
doaj   +2 more sources

Defining the constituents and functions of a lipid-based jumbo phage compartment

bioRxiv
Viruses are vulnerable to cellular defenses at the start of the infection when a single copy genome has not yet initiated de novo viral protein synthesis. A family of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, uses a protein-
Deepto Mozumdar, A. Fossati, Erica Stevenson, J. Guan, Eliza S. Nieweglowska, Sanjana Rao, D. Agard, D. Swaney, Joseph Bondy-Denomy   +8 more
semanticscholar   +2 more sources

Subcellular organization of viral particles during maturation of nucleus-forming jumbo phage. [PDF]

Sci Adv, 2022
Many eukaryotic viruses assemble mature particles within distinct subcellular compartments, but bacteriophages are generally assumed to assemble randomly throughout the host cell cytoplasm. Here, we show that viral particles of Pseudomonas nucleus-forming jumbo phage PhiPA3 assemble into a ...
Chaikeeratisak V, Khanna K, Nguyen KT, Egan ME, Enustun E, Armbruster E, Lee J, Pogliano K, Villa E, Pogliano J.   +9 more
europepmc   +5 more sources