Results 41 to 50 of about 654 (107)

Complete Genome Sequence of a Jumbo Bacteriophage, Escherichia Phage vB_EcoM_EC001

Microbiology Resource Announcements, 2022
Here, we report the genome sequence of a jumbo Escherichia phage vB_EcoM_EC001, a myovirus isolated from primary sludge using enterohemorrhagic Escherichia coli O157:H7. The genome is 240,200 bp long and has 270 predicted coding sequences, including a tryptophanyl tRNA gene.
Stevan Cucić, Andrew M. Kropinski, Janet Lin, Cezar M. Khursigara, Hany Anany   +4 more
openaire   +3 more sources

Molecular basis for anti-jumbo phage immunity by AVAST type 5.

Mol Cell
Abstract Jumbo phages protect their genomes from DNA-sensing bacterial defense systems by enclosing them within vesicles and nucleus-like compartments. Very little is known about defense systems specialized to counter these phages. Here, we show that AVAST Type 5 (Avs5) systems, part of the STAND superfamily and spanning three phylogenetic ...
Muralidharan A, Costa AR, Fierlier D, van den Berg DF, van den Bossche H, Zoumaro-Djayoon AD, Rodríguez-Molina A, Pabst M, Pacesa M, Correia BE, Brouns SJJ.   +10 more
europepmc   +3 more sources

Characterization and Genomic Analysis of a Novel Jumbo Bacteriophage vB_StaM_SA1 Infecting Staphylococcus aureus With Two Lysins

Frontiers in Microbiology, 2022
The development of new antimicrobial agents is critically needed due to the alarming increase in antibiotic resistance in bacterial pathogens. Phages have been widely considered as effective alternatives to antibiotics.
Bingyan Zhang, Bingyan Zhang, Huzhi Sun, Feiyang Zhao, Qian Wang, Qiang Pan, Yigang Tong, Huiying Ren   +7 more
doaj   +1 more source

Characterization and Genomic Analysis of PALS2, a Novel Staphylococcus Jumbo Bacteriophage

Frontiers in Microbiology, 2021
Staphylococcus aureus is an important human pathogen that can be frequently encountered in clinical and food-processing surroundings. Among the various countermeasures, bacteriophages have been considered to be promising alternatives to antibiotics.
Yoona Lee, Yoona Lee, Bokyung Son, Bokyung Son, Yoyeon Cha, Yoyeon Cha, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu   +9 more
doaj   +1 more source

Genome-wide identification of bacterial genes contributing to nucleus-forming jumbo phage infection. [PDF]

Nucleic Acids Res
Abstract The Chimalliviridae family of bacteriophages (phages) form a proteinaceous nucleus-like structure during infection of their bacterial hosts. This phage ‘nucleus’ compartmentalises phage DNA replication and transcription, and shields the phage genome from DNA-targeting defence systems such as CRISPR-Cas and restriction ...
Harding KR, Malone LM, Kyte NAP, Jackson SA, Smith LM, Fineran PC.   +5 more
europepmc   +3 more sources

Immediate targeting of host ribosomes by jumbo phage encoded proteins

, 2023
AbstractBacteriophages must seize control of the host gene expression machinery to promote their own protein synthesis. Since the bacterial hosts are armed with numerous anti-phage defence systems, it is essential that mechanisms of host take-over act immediately upon infection.
Gerovac M, Chihara K, Wicke L, Böttcher B, Lavigne R, Vogel J.   +5 more
europepmc   +2 more sources

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

, 2023
Large-genome bacteriophages (jumbo phages) of theChimalliviridaefamily assemble a nucleus-like compartment bounded by a protein shell that protects the replicating phage genome from host-encoded restriction enzymes and CRISPR/Cas nucleases. While the nuclear shell provides broad protection against host nucleases, it necessitates transport of mRNA out ...
Eray Enustun, Emily G. Armbruster, Jina Lee, Sitao Zhang, Brian A. Yee, Yajie Gu, Amar Deep, Jack T. Naritomi, Qishan Liang, Stefan Aigner, Benjamin A. Adler, Brady F. Cress, Jennifer A. Doudna, Vorrapon Chaikeeratisak, Don W. Cleveland, Majid Ghassemian, Gene W. Yeo, Joe Pogliano, Kevin D. Corbett   +18 more
openaire   +2 more sources

Jumbo phages are active against extensively drug-resistant eyedrop-associated Pseudomonas aeruginosa infections [PDF]

Antimicrobial Agents and Chemotherapy, 2023
ABSTRACT Antibiotic-resistant bacteria present an emerging challenge to human health. Their prevalence has been increasing across the globe due in part to the liberal use of antibiotics that has pressured them to develop resistance.
Cobián Güemes, Ana Georgina, Ghatbale, Pooja, Blanc, Alisha N., Morgan, Chase J., Garcia, Andrew, Leonard, Jesse, Huang, Lina, Kovalick, Grace, Proost, Marissa, Chiu, Megan, Kuo, Peiting, Oh, Joseph, Karthikeyan, Smruthi, Knight, Rob, Pogliano, Joe, Schooley, Robert T., Pride, David T.   +16 more
openaire   +4 more sources

Characterization of Novel Erwinia amylovora Jumbo Bacteriophages from Eneladusvirus Genus

Viruses, 2020
Jumbo phages, which have a genome size of more than 200 kb, have recently been reported for the first time. However, limited information is available regarding their characteristics because few jumbo phages have been isolated.
Sang Guen Kim, Sung Bin Lee, Sib Sankar Giri, Hyoun Joong Kim, Sang Wha Kim, Jun Kwon, Jungkum Park, Eunjung Roh, Se Chang Park   +8 more
doaj   +1 more source

Jumbo Phages: A Comparative Genomic Overview of Core Functions and Adaptions for Biological Conflicts

Viruses, 2021
Jumbo phages have attracted much attention by virtue of their extraordinary genome size and unusual aspects of biology. By performing a comparative genomics analysis of 224 jumbo phages, we suggest an objective inclusion criterion based on genome size ...
Lakshminarayan M. Iyer, Vivek Anantharaman, Arunkumar Krishnan, A. Maxwell Burroughs, L. Aravind   +4 more
doaj   +1 more source