Results 11 to 20 of about 585 (130)

Multisubunit RNA Polymerases of Jumbo Bacteriophages

Viruses, 2020
Prokaryotic viruses with DNA genome longer than 200 kb are collectively referred to as “jumbo phages”. Some representatives of this phylogenetically diverse group encode two DNA-dependent RNA polymerases (RNAPs)—a virion RNAP and a non-virion RNAP.
Maria L. Sokolova, Inna Misovetc, Konstantin V. Severinov   +2 more
doaj   +3 more sources

Pseudomonas Phage PaBG—A Jumbo Member of an Old Parasite Family [PDF]

Viruses, 2020
Bacteriophage PaBG is a jumbo Myoviridae phage isolated from water of Lake Baikal. This phage has limited diffusion ability and thermal stability and infects a narrow range of Pseudomonas aeruginosa strains.
Peter Evseev, Nina Sykilinda, Anna Gorshkova, Lidia Kurochkina, Rustam Ziganshin, Valentin Drucker, Konstantin Miroshnikov   +6 more
doaj   +3 more sources

Isolation and Characterization of Salmonella Jumbo-Phage pSal-SNUABM-04 [PDF]

Viruses, 2020
The increasing emergence of antimicrobial resistance has become a global issue. Therefore, many researchers have attempted to develop alternative antibiotics. One promising alternative is bacteriophage.
Jun Kwon, Sang Guen Kim, Hyoun Joong Kim, Sib Sankar Giri, Sang Wha Kim, Sung Bin Lee, Se Chang Park   +6 more
doaj   +3 more sources

vB_PaeM_MIJ3, a Novel Jumbo Phage Infecting Pseudomonas aeruginosa, Possesses Unusual Genomic Features [PDF]

Frontiers in Microbiology, 2019
Phages are the most abundant biological entity on Earth. There are many variants in phage virion sizes, morphology, and genome sizes. Large virion sized phages, with genome sizes greater than 200 kbp have been identified and termed as Jumbo phages. These
Mohammed Imam, Mohammed Imam, Bandar Alrashid, Bandar Alrashid, Faizal Patel, Ahmed S. A. Dowah, Nathan Brown, Andrew Millard, Martha R. J. Clokie, Edouard E. Galyov   +9 more
doaj   +3 more sources

Interactions between Jumbo Phage SA1 and Staphylococcus: A Global Transcriptomic Analysis

Microorganisms, 2022
Staphylococcus aureus (S. aureus) is an important zoonotic pathogen that poses a serious health concern to humans and cattle worldwide. Although it has been proven that lytic phages may successfully kill S.
Bingyan Zhang, Jiayi Xu, Xiaoqi He, Yigang Tong, Huiying Ren   +4 more
doaj   +3 more sources

Jumbo phage killer immune system targets early infection of nucleus-forming phages

Cell
Jumbo bacteriophages of the ϕKZ-like family assemble a lipid-based early phage infection (EPI) vesicle and a proteinaceous nucleus-like structure during infection. These structures protect the phage from nucleases and may create selective pressure for immunity mechanisms targeting this specific phage family. Here, we identify "jumbo phage killer" (Juk),
Li, Yuping, Linlin, Guan, Isabelle, Becher, Kira S, Makarova, Xueli, Cao, Surabhi, Hareendranath, Jingwen, Guan, Frank, Stein, Siqi, Yang, Arne, Boergel, Karine, Lapouge, Kim, Remans, David, Agard, Mikhail, Savitski, Athanasios, Typas, Eugene V, Koonin, Yue, Feng, Joseph, Bondy-Denomy   +17 more
exaly   +3 more sources

Unexplored diversity and molecular genetic signatures of chimallin and phuz encoding phages [PDF]

BMC Genomics
Nucleus-forming phages are a class of jumbo phages with the capacity to form a protein nuclear shell during infection within a bacterial host. This protein nuclear shell protects the replication of the phage genome by excluding host defense factors ...
Shize Sun, Cunyuan Li, Jia Sun, Xiaoyue Li, Min Liu, Xia Li, Kaiping Liu, Hui Li, Jinming Yu, Ping Zhou, Limin Wang, Kuojun Cai, Wei Ni, Shengwei Hu   +13 more
doaj   +2 more sources

Phage isolation and functional characterization reveal strong antibiofilm activity against Pseudomonas aeruginosa in a cystic fibrosis sputum model [PDF]

Frontiers in Cellular and Infection Microbiology
Pseudomonas aeruginosa is an opportunistic pathogen that forms persistent biofilms in the lungs of cystic fibrosis and other chronic pulmonary disease patients, contributing to antibiotic tolerance, recurrent infection, and clinical decline.
Madeline Bowder, Hannah Kapoor, Steven J Carrell, Lia Danelishvili, Lia Danelishvili   +4 more
doaj   +2 more sources

Characterization and genomic analysis of Sharanji: a jumbo bacteriophage of Escherichia coli [PDF]

Virology Journal
Background Bacteriophages are the most genetically diverse biological entities in nature. Our current understanding of phage biology primarily stems from studies on a limited number of model bacteriophages.
Sharayu Magar, Sivaraj Barath, Debmitra Sen, Ranjith Kumar Singari, T. Nagarajan, Anjali Parmar, Sutharsan Govindarajan   +6 more
doaj   +2 more sources

fENko-Kae01 is a flagellum-specific jumbo phage infecting Klebsiella aerogenes

BMC Microbiology
Background Klebsiella aerogenes is an opportunistic pathogen that causes a wide variety of infections. Due to the rising problem of antibiotic resistance, novel antibiotics and strategies to combat bacterial infections are needed.
Kira Ranta, Mikael Skurnik, Saija Kiljunen   +2 more
doaj   +4 more sources