Jumbo phages are active against extensively drug-resistant eyedrop-associated Pseudomonas aeruginosa infections. [PDF]
Antimicrob Agents Chemother, 2023 Antibiotic-resistant bacteria present an emerging challenge to human health. Their prevalence has been increasing across the globe due in part to the liberal use of antibiotics that has pressured them to develop resistance.
Cobián Güemes AG +16 more
europepmc +7 more sources
Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection
Molecular Cell, 2022 Bacteria have diverse defences against phages. In response, jumbo phages evade multiple DNA-targeting defences by protecting their DNA inside a nucleus-like structure.
Peter C Fineran
exaly +4 more sources
Characterization of a novel Jumbo phage JP4 with potential to control pathogenic Escherichia coli [PDF]
Virology JournalBackground Amidst rising antimicrobial resistance, bacteriophage (phage) therapy has re-emerged as a pivotal weapon against multidrug-resistant pathogens. Jumbo phages, distinguished by large genomes, show particular therapeutic promise.
Kexin Zhang +13 more
doaj +3 more sources
Unexplored diversity and molecular genetic signatures of chimallin and phuz encoding phages [PDF]
BMC GenomicsNucleus-forming phages are a class of jumbo phages with the capacity to form a protein nuclear shell during infection within a bacterial host. This protein nuclear shell protects the replication of the phage genome by excluding host defense factors ...
Shize Sun +13 more
doaj +3 more sources
The complex developmental mechanisms of nucleus-forming jumbo phages. [PDF]
Curr Opin MicrobiolMozumdar D, A Agard D, Bondy-Denomy J.
europepmc +3 more sources
Therapeutic application of a jumbo bacteriophage against metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates [PDF]
Journal of Biomedical ScienceBackground Therapeutic options against metallo-β-lactamase producing P. aeruginosa (MBL-PA) are limited due to multi-drug resistance. A jumbo phage isolated from wastewater in Greece was characterized microbiologically and genetically and evaluated for ...
Paschalis Paranos +9 more
doaj +3 more sources
A flagella-dependent Burkholderia jumbo phage controls rice seedling rot and steers Burkholderia glumae toward reduced virulence in rice seedlings [PDF]
mBioBacteriophages (phages) are being investigated as potential biocontrol agents for the suppression of bacterial diseases in cultivated crops. Jumbo bacteriophages, which possess genomic DNA larger than 200 kbp, generally have a broader host range than ...
Brittany S. I. Supina +4 more
doaj +3 more sources
fENko-Kae01 is a flagellum-specific jumbo phage infecting Klebsiella aerogenes
BMC MicrobiologyBackground Klebsiella aerogenes is an opportunistic pathogen that causes a wide variety of infections. Due to the rising problem of antibiotic resistance, novel antibiotics and strategies to combat bacterial infections are needed.
Kira Ranta +2 more
doaj +5 more sources
Jumbo phage killer immune system targets early infection of nucleus-forming phages. [PDF]
CellJumbo bacteriophages of the ϕKZ-like family assemble a lipid-based early phage infection (EPI) vesicle and a proteinaceous nucleus-like structure during infection. These structures protect the phage from nucleases and may create selective pressure for immunity mechanisms targeting this specific phage family. Here, we identify "jumbo phage killer" (Juk),
Yuping L +17 more
europepmc +4 more sources
Isolation and characterization of fMGyn-Pae01, a phiKZ-like jumbo phage infecting Pseudomonas aeruginosa [PDF]
Virology JournalBackground Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide variety of infections, and belongs to the group of ESKAPE pathogens that are the leading cause of healthcare-associated infections and have high level of antibiotic ...
Kira Ranta +2 more
doaj +3 more sources