Therapeutic application of a jumbo bacteriophage against metallo-β-lactamase producing Pseudomonas aeruginosa clinical isolates [PDF]
Journal of Biomedical ScienceBackground Therapeutic options against metallo-β-lactamase producing P. aeruginosa (MBL-PA) are limited due to multi-drug resistance. A jumbo phage isolated from wastewater in Greece was characterized microbiologically and genetically and evaluated for ...
Paschalis Paranos +9 more
doaj +2 more sources
Proteomic analysis of a novel Bacillus Jumbo phage revealing glycoside hydrolase as structural component [PDF]
Frontiers in Microbiology, 2016 Tailed phages with genomes of larger than 200 kbp are classified as Jumbo phages and exhibited extremely high uncharted diversity. The genomic annotation of Jumbo phage is often disappointing because most of the predicted proteins, including structural ...
Yihui eYuan, Meiying eGao
doaj +3 more sources
Systematic bacteriophage selection for the lysis of multiple Pseudomonas aeruginosa strains [PDF]
Frontiers in Cellular and Infection MicrobiologyPseudomonas aeruginosa is an opportunistic pathogen causing severe infections of the lung, burn wounds and eyes. Due to its intrinsic high antibiotic resistance the bacterium is difficult to eradicate.
Finja Rieper +11 more
doaj +2 more sources
A flagella-dependent Burkholderia jumbo phage controls rice seedling rot and steers Burkholderia glumae toward reduced virulence in rice seedlings [PDF]
mBioBacteriophages (phages) are being investigated as potential biocontrol agents for the suppression of bacterial diseases in cultivated crops. Jumbo bacteriophages, which possess genomic DNA larger than 200 kbp, generally have a broader host range than ...
Brittany S. I. Supina +4 more
doaj +2 more sources
The Biology of Nucleus-Forming Jumbo Phages. [PDF]
Annu Rev GenetNucleus-forming jumbo bacteriophages display a surprisingly intricate replication cycle inside of bacterial host cells, challenging the long-standing paradigm of prokaryotic simplicity. The phage nucleus encloses phage DNA in a protein shell, strictly uncouples transcription from translation, and facilitates selective protein import and messenger RNA ...
Birkholz EA, Armbruster EG, Pogliano J.
europepmc +2 more sources
Jumbo phages are active against extensively drug-resistant eyedrop-associated Pseudomonas aeruginosa infections. [PDF]
Antimicrob Agents Chemother, 2023 ABSTRACT Antibiotic-resistant bacteria present an emerging challenge to human health. Their prevalence has been increasing across the globe due in part to the liberal use of antibiotics that has pressured them to develop resistance.
Cobián Güemes AG +16 more
europepmc +6 more sources
Isolation and characterization of fMGyn-Pae01, a phiKZ-like jumbo phage infecting Pseudomonas aeruginosa [PDF]
Virology JournalBackground Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide variety of infections, and belongs to the group of ESKAPE pathogens that are the leading cause of healthcare-associated infections and have high level of antibiotic ...
Kira Ranta +2 more
doaj +2 more sources
A cytoskeletal vortex drives phage nucleus rotation during jumbo phage replication in E. coli [PDF]
Cell Reports, 2021 AbstractVortex-like arrays of cytoskeletal filaments that drive cytoplasmic streaming and nucleus rotation have been identified in eukaryotes, but similar structures have not been described in prokaryotes. The only known example of a rotating intracellular body in prokaryotic cells occurs when nucleus-forming jumbo phages infect Pseudomonas.
Erica A. Birkholz +8 more
openaire +3 more sources
Isolation protocol of jumbo phage from winter grass soil [PDF]
IOP Conference Series: Earth and Environmental Science, 2021 Abstract Jumbo phage can isolated by two different methods and protocols. It depends on size, phage species, substrate sources, environment, media and tools. Each method has positive and negative results within each factors. The research aimed to determine the suitable protocol to isolated the jumbo phages from winter grass soil during ...
A Wafa +3 more
openaire +1 more source
A Novel Jumbo Phage PhiMa05 Inhibits Harmful Microcystis sp. [PDF]
Frontiers in Microbiology, 2021 Microcystis poses a concern because of its potential contribution to eutrophication and production of microcystins (MCs). Phage treatment has been proposed as a novel biocontrol method for Microcystis. Here, we isolated a lytic cyanophage named PhiMa05 with high efficiency against MCs-producing Microcystis strains.
Ampapan Naknaen +6 more
openaire +4 more sources