vB_PaeM_MIJ3, a Novel Jumbo Phage Infecting Pseudomonas aeruginosa, Possesses Unusual Genomic Features [PDF]
Frontiers in Microbiology, 2019 Phages are the most abundant biological entity on Earth. There are many variants in phage virion sizes, morphology, and genome sizes. Large virion sized phages, with genome sizes greater than 200 kbp have been identified and termed as Jumbo phages. These
Mohammed Imam +9 more
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Xanthomonas citri jumbo phage XacN1 exhibits a wide host range and high complement of tRNA genes [PDF]
Scientific Reports, 2018 Xanthomonas virus (phage) XacN1 is a novel jumbo myovirus infecting Xanthomonas citri, the causative agent of Asian citrus canker. Its linear 384,670 bp double-stranded DNA genome encodes 592 proteins and presents the longest (66 kbp) direct terminal ...
Ahmed A Askora +2 more
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Interactions between Jumbo Phage SA1 and Staphylococcus: A Global Transcriptomic Analysis
Microorganisms, 2022 Staphylococcus aureus (S. aureus) is an important zoonotic pathogen that poses a serious health concern to humans and cattle worldwide. Although it has been proven that lytic phages may successfully kill S.
Bingyan Zhang +4 more
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Frontiers in Microbiology, 2019 A common cause of human food poisoning is through ingestion of pork products contaminated with Salmonella spp. Worryingly multi-drug resistant (MDR) Salmonella strains have been isolated from pigs, which motivates the need for alternative antimicrobials.
Anisha M. Thanki +3 more
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The human oral phageome is highly diverse and rich in jumbo phages [PDF]
bioRxiv, 2020 Until recently, the contribution of bacteriophages to the composition and function of the human microbiome has been largely overlooked. Recent developments in discovering novel bacteriophages from human metagenomes have been mostly focused on the gut ...
Victoria R. Carr +5 more
semanticscholar +2 more sources
Novel bacteriophages targeting wheat phyllosphere bacteria carry DNA modifications and single-strand breaks [PDF]
Virus ResearchThe phyllosphere microbiome can positively or negatively impact plant health and growth, but we currently lack the tools to control microbiome composition.
Peter Erdmann Dougherty +6 more
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Molecular basis for anti-jumbo phage immunity by AVAST Type 5
bioRxivAbstract Jumbo phages protect their genomes from DNA-sensing bacterial defense systems by enclosing them within vesicles and nucleus-like compartments. Very little is known about defense systems specialized to counter these phages. Here, we show that AVAST Type 5 (Avs5) systems, part of the STAND superfamily and spanning three phylogenetic ...
Muralidharan A +9 more
europepmc +3 more sources
Proteomic analysis of a novel Bacillus Jumbo phage revealing glycoside hydrolase as structural component [PDF]
Frontiers in Microbiology, 2016 Tailed phages with genomes of larger than 200 kbp are classified as Jumbo phages and exhibited extremely high uncharted diversity. The genomic annotation of Jumbo phage is often disappointing because most of the predicted proteins, including structural ...
Yihui eYuan, Meiying eGao
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Systematic bacteriophage selection for the lysis of multiple Pseudomonas aeruginosa strains [PDF]
Frontiers in Cellular and Infection MicrobiologyPseudomonas aeruginosa is an opportunistic pathogen causing severe infections of the lung, burn wounds and eyes. Due to its intrinsic high antibiotic resistance the bacterium is difficult to eradicate.
Finja Rieper +11 more
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A phage nucleus-associated RNA-binding protein is required for jumbo phage infection
Nucleic Acids ResearchLarge-genome bacteriophages (jumbo phages) of the proposed family Chimalliviridae assemble a nucleus-like compartment bounded by a protein shell that protects the replicating phage genome from host-encoded restriction enzymes and DNA-targeting CRISPR-Cas
Eray Enustun +20 more
semanticscholar +5 more sources