Results 11 to 20 of about 5,647 (215)
A single mutation (V64G) within the RING Domain of Z attenuates Junin virus. [PDF]
PLoS Neglected Tropical Diseases, 2020 Junin virus (JUNV) is a New World arenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). Candid#1 (Can) is a live-attenuated vaccine strain of JUNV that since its introduction has resulted in a marked decrease in AHF incidence ...
Steven J Hallam +7 more
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RIG-I enhanced interferon independent apoptosis upon Junin virus infection. [PDF]
PLoS ONE, 2014 Junin virus (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF), a human disease with a high case-fatality rate. It is widely accepted that arenaviral infections, including JUNV infections, are generally non-cytopathic. In contrast, here
Olga A Kolokoltsova +10 more
doaj +2 more sources
In situ insights into antibody-mediated neutralization of a pre-fusion Junin virus glycoprotein complex [PDF]
Cell ReportsSummary: A transmembrane glycoprotein complex (GPC) decorates the Junin mammarenavirus (JUNV) that causes New World hemorrhagic fevers. We leveraged single-particle cryoelectron microscopy (cryo-EM) to image the full-length JUNV GPC directly on ...
Lily J. Taylor +10 more
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Antigen vehiculization particles based on the Z protein of Junin virus [PDF]
BMC Biotechnology, 2012 Background Arenavirus matrix protein Z plays an important role in virus budding and is able to generate enveloped virus-like-particles (VLPs) in absence of any other viral proteins.
Borio Cristina S +6 more
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Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages. [PDF]
PLoS Neglected Tropical Diseases, 2011 The mechanisms underlying the development of disease during arenavirus infection are poorly understood. However, common to all hemorrhagic fever diseases is the involvement of macrophages as primary target cells, suggesting that the immune response in ...
Allison Groseth +6 more
doaj +3 more sources
Potent inhibition of Junín virus infection by interferon in murine cells. [PDF]
PLoS Neglected Tropical Diseases, 2014 The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV.
Cheng Huang +6 more
doaj +2 more sources
Vaccine Candidates against Arenavirus Infections
Vaccines, 2023 The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Takeshi Saito +5 more
doaj +1 more source
Junin virus structural proteins [PDF]
Journal of Virology, 1977 Polyacrylamide gel electrophoresis of purified Junin virus revealed six distinct structural polypeptides, two major and four minor ones. Four of these polypeptides appeared to be covalently linked with carbohydrate. The molecular weights of the six proteins, estimated by coelectrophoresis with marker proteins, ranged from 25,000 to 91,000.
Z M, De Martínez Segovia, M I, De Mitri
openaire +2 more sources
Siglec-1 Expressed on Dendritic Cells is a New Receptor Implicated in Arenavirus Uptake
Proceedings, 2020 Arenaviruses are enveloped viruses that cause hemorrhagic fever outbreaks in humans and still lack an effective antiviral treatment. Upon early infection, these viruses target dendritic cells (DCs), which can promote systemic viral dissemination ...
Xabier Muniz-Trabudua +7 more
doaj +1 more source
Антибиотики и Химиотерапия, 2023 The article presents an analysis of studies assessing the effectiveness of new nonspecific medications against hemorrhagic fevers caused by arenaviruses.
Т. Е. Sizikova +2 more
doaj +1 more source