Monoclonal antibody therapy for Junin virus infection. [PDF]
Proc Natl Acad Sci U S A, 2016 Significance There are no Food and Drug Administration approved drugs available for preventing or treating Argentine hemorrhagic fever (AHF), and the current treatment option is limited to administration of immune plasma. With the expanding clinical use of monoclonal antibodies (mAbs) for acute and chronic conditions, it has become ...
Zeitlin L +22 more
europepmc +5 more sources
Modulation of the Aryl Hydrocarbon Receptor Signaling Pathway Impacts on Junín Virus Replication. [PDF]
Viruses, 2023 Junín virus (JUNV), a member of the family Arenaviridae, is the etiological agent of the Argentine hemorrhagic fever, an endemic disease in the rural region of Argentina lacking a specific chemotherapy.
Pelaez MA +6 more
europepmc +2 more sources
Inhibitors of the p38 cell signaling pathway as antiviral compounds against Junín virus. [PDF]
Arch Virol, 2022 In the present study, we analyzed the modulation of p38 cell signaling by Junín virus (JUNV) and evaluated the antiviral activity of p38 inhibitors against JUNV. While JUNV induced a progressive activation of p38 throughout the infection in Vero cells, a
Brunetti JE +3 more
europepmc +2 more sources
Immunization with GP1 but Not Core-like Particles Displaying Isolated Receptor-Binding Epitopes Elicits Virus-Neutralizing Antibodies against Junín Virus. [PDF]
Vaccines (Basel), 2022 New World arenaviruses are rodent-transmitted viruses and include a number of pathogens that are responsible for causing severe human disease. This includes Junín virus (JUNV), which is the causative agent of Argentine hemorrhagic fever.
Roman-Sosa G +11 more
europepmc +2 more sources
Second-Generation Live-Attenuated Candid#1 Vaccine Virus Resists Reversion and Protects against Lethal Junín Virus Infection in Guinea Pigs. [PDF]
J Virol, 2021 Our most successful vaccines comprise weakened strains of virus that initiate a limited and benign infection in immunized persons. The live-attenuated Candid#1 strain of Junín virus (JUNV) was developed to protect field workers in Argentina from rodent ...
Gowen BB +7 more
europepmc +2 more sources
Coadministration of LHF-535 and favipiravir protects against experimental Junín virus infection and disease. [PDF]
Antiviral ResArgentine hemorrhagic fever, caused by Junín virus (JUNV), is the most common of the South American arenaviral hemorrhagic fevers. The disease has a case fatality rate of 15–30% in untreated patients.
Westover JB +6 more
europepmc +2 more sources
Alternative translation contributes to the generation of a cytoplasmic subpopulation of the Junín virus nucleoprotein that inhibits caspase activation and innate immunity. [PDF]
J VirolThe highly pathogenic arenavirus, Junín virus (JUNV), expresses three truncated alternative isoforms of its nucleoprotein (NP), i.e., NP53kD, NP47kD, and NP40kD.
Bostedt L +7 more
europepmc +2 more sources
Climate Change Impact on Human-Rodent Interfaces: Modeling Junin Virus Reservoir Shifts. [PDF]
EcohealthThe drylands vesper mouse (Calomys musculinus) is the primary host for Junin mammarenavirus (JUNV), the etiological agent of Argentine hemorrhagic fever in humans. We assessed the potential distribution of C.
Flores-Pérez N +3 more
europepmc +2 more sources
Development of horse neutralizing immunoglobulin and immunoglobulin fragments against Junín virus. [PDF]
Antiviral Res, 2020 Argentine haemorrhagic fever (AHF) is a rodent-borne disease with a lethality as high as ~30%, which is caused by the New World arenavirus, Junín virus (JUNV). It was once a major epidemic in South America and puts millions of people in Argentina at risk.
Pan X, Wu Y, Wang W, Zhang L, Xiao G.
europepmc +2 more sources
The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome. [PDF]
J Virol, 2020 The development of vaccines and therapeutics to combat viral hemorrhagic fevers remains a top priority within the Implementation Plan of the U.S. Department of Health and Human Services Public Health Emergency Medical Countermeasures Enterprise.
Manning JT +8 more
europepmc +2 more sources