Multi-epitope-based vaccine designing against Junín virus glycoprotein: immunoinformatics approach
Future Journal of Pharmaceutical SciencesBackground The Junín virus (JUNV) is well known for causing argentine haemorrhagic fever (AHF), a severe endemic disease in farming premises. The glycoprotein of JUNV is an important therapeutic target in vaccine design.
Mallari Praveen
doaj +2 more sources
Potent inhibition of Junín virus infection by interferon in murine cells. [PDF]
PLoS Neglected Tropical Diseases, 2014 The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV.
Cheng Huang +6 more
doaj +2 more sources
Lassa fever and Argentine hemorrhagic fever treatment in guinea pigs using broad-spectrum cap-dependent endonuclease inhibitors [PDF]
mBioThe class Bunyaviricetes encompasses several highly pathogenic viruses that cause lethal hemorrhagic fevers. Due to their limited prevention and treatment options and high pathogenicity, these viruses require handling in biosafety level-4 facilities ...
Junki Maruyama +18 more
doaj +2 more sources
Comparative studies on Mopeia viruses and other Arenaviridae, particularly Lassa virus [PDF]
, 1983 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Serologically related arenaviruses have been isolated from West Africa, Mozambique, Zimbabwe and the Central African Republic.
Lloyd, Graham
core +7 more sources
Immunogenicity of recombinant vesicular stomatitis virus-vectored vaccines expressing the Machupo virus glycoprotein in different genome positions [PDF]
Journal of VirologyRecombinant vesicular stomatitis virus (rVSV) is a powerful vaccine platform that elicits durable cellular and humoral immune responses. rVSV vaccines have successfully been used for various hemorrhagic fever-causing viruses. Here, we create and evaluate
Rachel Erickson, Paul Bates
doaj +2 more sources
A Proteomics Survey of Junín Virus Interactions with Human Proteins Reveals Host Factors Required for Arenavirus Replication. [PDF]
J Virol, 2018 Ziegler CM +10 more
europepmc +2 more sources
Epistastic Interactions within the Junín Virus Envelope Glycoprotein Complex Provide an Evolutionary Barrier to Reversion in the Live-Attenuated Candid#1 Vaccine. [PDF]
J Virol, 2018 York J, Nunberg JH.
europepmc +2 more sources
A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). [PDF]
J Virol, 2017 King BR +8 more
europepmc +2 more sources
Vaccine Candidates against Arenavirus Infections
Vaccines, 2023 The viral family Arenaviridae contains several members that cause severe, and often lethal, diseases in humans. Several highly pathogenic arenaviruses are classified as Risk Group 4 agents and must be handled in the highest biological containment ...
Takeshi Saito +5 more
doaj +1 more source
Siglec-1 Expressed on Dendritic Cells is a New Receptor Implicated in Arenavirus Uptake
Proceedings, 2020 Arenaviruses are enveloped viruses that cause hemorrhagic fever outbreaks in humans and still lack an effective antiviral treatment. Upon early infection, these viruses target dendritic cells (DCs), which can promote systemic viral dissemination ...
Xabier Muniz-Trabudua +7 more
doaj +1 more source