Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages. [PDF]
PLoS Neglected Tropical Diseases, 2011 The mechanisms underlying the development of disease during arenavirus infection are poorly understood. However, common to all hemorrhagic fever diseases is the involvement of macrophages as primary target cells, suggesting that the immune response in ...
Allison Groseth +6 more
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Frontiers in Microbiology, 2021 Ebola virus infection causes severe hemorrhagic fever, and its mortality rates varied from 25 to 90% in the previous outbreaks. The highly infectious and lethal nature of this virus highlights the need for reliable and sensitive diagnostic methods to ...
Wenwu Yao +5 more
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Spatial expansions and travelling waves of rabies in vampire bats [PDF]
, 2016 A major obstacle to anticipating the cross-species transmission of zoonotic diseases and developing novel strategies for their control is the scarcity of data informing how these pathogens circulate within natural reservoir populations.
Benavides, Julio A. +2 more
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Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. [PDF]
PLoS Neglected Tropical Diseases, 2011 Lassa and Junín viruses are the most prominent members of the Arenaviridae family of viruses that cause viral hemorrhagic fever syndromes Lassa fever and Argentine hemorrhagic fever, respectively.
Michelle Mendenhall +6 more
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Junin Virus Infection in Genetically Athymic Mice
Intervirology, 1983 The progression of Junin virus infection was studied in congenitally athymic mice. Immunocompetent littermates were used as infected controls. As expected, the latter developed lethal encephalitis, with viremia and considerable viral replication in the brain.
M C, Weissenbacher +5 more
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Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression [PDF]
, 2017 Junin virus (JUNV), a highly pathogenic New World arenavirus, is the causative agent of Argentine hemorrhagic fever (AHF). The live-attenuated Candid #1 (Can) strain currently serves as a vaccine for at-risk populations. We have previously shown that the
Alexey V. Seregin +7 more
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Pathogens, 2015 Arenaviruses include multiple human pathogens ranging from the low-risk lymphocytic choriomeningitis virus (LCMV) to highly virulent hemorrhagic fever (HF) causing viruses such as Lassa (LASV), Junin (JUNV), Machupo (MACV), Lujo (LUJV), Sabia (SABV ...
Junjie Shao, Yuying Liang, Hinh Ly
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A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease. [PDF]
, 2016 UNLABELLED: Arenaviruses are emerging viruses including several causative agents of severe hemorrhagic fevers in humans. The advent of next-generation sequencing technology has greatly accelerated the discovery of novel arenavirus species.
Bergeron, E. +7 more
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Protection Against Junin Virus by Immunization with Live Tacaribe Virus
Experimental Biology and Medicine, 1965 SummaryAdult guinea pigs immunized with the live Tacaribe virus are able to resist challenge with a large dose of Junin virus to which they are normally susceptible. Sera from the Tacaribe virus-immunized guinea pigs contain abundant homologous antibody demonstrable by both complement-fixation and plaque neutralization tests.
N, TAURASO, A, SHELOKOV
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Biological Activities of Junin Virus Proteins
Intervirology, 1980 In the Junin virus-infected cell, there is a soluble antigen (SAg), which we have detected by complement fixation.
Maria Ines de Mitri +1 more
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