Results 61 to 70 of about 5,614 (215)

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses. [PDF]

, 2014
Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses.
Davis, Benjamin, Freedman, Bruce D, Han, Ziying, Harty, Ronald N, Lee, Michael S, Liu, Yuliang, Lu, Jianhong, Olson, Mark A, Reitz, Allen B, Ruthel, Gordon, Schnell, Matthias J, Wrobel, Jay E   +11 more
core   +2 more sources

Evaluating the Potential Adverse Effects of Favipiravir on Biochemical, Histopathological, and Spermatological Parameters in Male Rats' Testicular Tissue

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
ABSTRACT Favipiravir is a selective RNA polymerase inhibitor and a broad‐spectrum antiviral drug. Favipiravir reduces cell proliferation by inhibiting RNA transcription, particularly in rapidly proliferating cells such as spermatogonia. The aim of this study was to investigate the effects and mechanism of action of favipiravir (T‐705) on sperm quality ...
Ali Doğan Ömür, Gamze Uçak, Adem Kara, Elif Erbaş, Serkan Ali Akarsu, Seçkin Özkanlar, Nevra Aydemir Celep   +6 more
wiley   +1 more source

Rapid Sequence Identification of Potential Pathogens Using Techniques from Sparse Linear Algebra

, 2015
The decreasing costs and increasing speed and accuracy of DNA sample collection, preparation, and sequencing has rapidly produced an enormous volume of genetic data. However, fast and accurate analysis of the samples remains a bottleneck. Here we present
Chiu, Nelson, Dodson, Stephanie, Kepner, Jeremy, Ricke, Darrell O., Shcherbina, Anna   +4 more
core   +1 more source

The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. [PDF]

, 2018
Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats. Recent studies of diseases caused by several RNA viruses in people and other species indicate that antiviral therapy may be effective against FIP in ...
Bauer, K, Eckstrand, C, Liepnieks, M, Murakami, E, Murphy, BG, Park, Y, Pedersen, NC, Perron, M   +7 more
core   +1 more source

Pests and diseases affecting potato landraces and bred varieties grown in Peru under indigenous farming system [PDF]

, 2015
The major pests and diseases were identified and quantified on thirteen potato landraces and three bred varieties cultivated in Peru. Late blight (Phytophthora infestans) was the primary biotic constraint affecting plants before flowering with an average
Andrade-Piedra, J.L., Barreto Bravo, M., Forbes, G., Pérez, W., Valverde Marival, M.   +4 more
core   +1 more source

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components

WIREs RNA, Volume 16, Issue 2, March/April 2025.
Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus, Eliana Dukhno, Rupali Kapoor, Piotr Gerlach   +3 more
wiley   +1 more source

Enzootic Transmission of Yellow Fever Virus in Peru

Emerging Infectious Diseases, 2003
The prevailing paradigm of yellow fever virus (YFV) ecology in South America is that of wandering epizootics. The virus is believed to move from place to place in epizootic waves involving monkeys and mosquitoes, rather than persistently circulating ...
Juliet E. Bryant, Heiman Wang, Cesar Cabezas, Gladys Ramirez, Douglas Watts, Kevin Russell, Alan Barrett   +6 more
doaj   +1 more source

Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses

Journal of Infection and Public Health, 2023
Background: Multiplex real-time PCR is a quick and cost effective method for detection of various gene simultaneously. HFSV (Hemorrhagic Fever Syndrome Virus) is a newly emerging infectious disease because of globalization and climate change. We tried to
Yoonhyuk Choi, Younghee Kim
doaj   +1 more source

Protection Conferred against Junin Virus Infection in Rats

Intervirology, 1984
2-day-old Wistar rats intracerebrally infected with the XJC13 strain of virus exhibited a 5% survival rate which rose to 71% after immune serum treatment. Brain viral titers were relatively unaffected by this treatment. Histologic studies showed necrosis in the cerebellum and brain cortex with mononuclear cell infiltration in both treated and ...
J L, Blejer, N V, Galassi, V M, Saavedra, M R, Nejamkis   +3 more
openaire   +2 more sources

Tolerance has its limits: how the thymus copes with infection [PDF]

, 2013
The thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture.
AbuAttieh, Ahmed, Auwaerter, Baroni, Borges, Brilot, Brito, Calabro, Calello, Cardenas Palomo, Cavalcante, Cavalcante, Chen, Claudia Nobrega, Cláudio Nunes-Alves, Corbeau, Cotta-de-Almeida, Deobagkar-Lele, Dooley, Douek, Feldman, Francelin, Freitas, Gameiro, Godfraind, Gossmann, Gray, Hale, Ho Tsong Fang, Huldt, Islam, Jamieson, Korostoff, Lamontagne, Margarida Correia-Neves, Martin, Mendes-da-Cruz, Mendes-da-Cruz, Milich, Miller, Mocarski, Nascimbeni, Nascimbeni, Nobrega, Nobrega, Nobrega, Ozeki, Pellegrini, Perez, Prabhu, Proietto, Raviola, Reiley, Ross, Rozmyslowicz, Samuel M. Behar, Sauce, Savino, Savino, Schmitt, Song, Sotomayor, Stanley, Starr, Stevens, Su, Sutton, Takahama, Tsuji, Uldrich, Valentin, Vezys, Vogel, Weiss, Wolf, Wykrzykowska, Yoshimura, Yoshimura   +77 more
core   +1 more source