Results 91 to 100 of about 11,948,174 (351)

Convergence of carbapenem resistance and hypervirulence leads to high mortality in patients with postoperative Klebsiella pneumoniae meningitis

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The aims of this study were to investigate the characteristics of Klebsiella pneumoniae meningitis and the impact of convergence of carbapenem resistance and hypervirulence on patient mortality.Methods: Antimicrobial resistance and ...
Yuming Li, Dakang Hu, Xiaobo Ma, Dan Li, Dongxing Tian, Ye Gong, Xiaofei Jiang   +6 more
doaj   +1 more source

Management of KPC-Producing Klebsiella pneumoniae Infections [PDF]

, 2015
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic ...
M. Bassetti, D.R. Giacobbe, H. Giamarellou, C. Viscoli, G.L. Daikos, G. Dimopoulos, F.G. De Rosa, E.J. Giamarellos-Bourboulis, G.M. Rossolini, E. Righi, I. Karaiskos, M. Tumbarello, D.P. Nicolau, P.L. Viale, G. Poulakou, Rossolini, Munoz-Price, Grundmann, Maltezou, Giacobbe, Banerjee, Girmenia, Patel, Bauer, Arena, Kostrzewa, Rotova, Gaibani, Hoyos-Mallecot, Salimnia, Vincent, Arena, Paul, Zusman, Dickstein, Tzouvelekis, Tumbarello, Tumbarello, Daikos, Gutiérrez-Gutiérrez, Del Bono, Pea, Tenover, Clinical and Laboratory Standards Institute (CLSI), Nation, Capone, Monaco, Giacobbe, Giamarellou, Spyropoulou, Meletis, Karaiskos, Karaiskos, Sorlí, Sandri, Nation, Gonzalez-Padilla, Machuca, Stankowicz, Poulakou, Bassetti, Montravers, Bassetti, Ramirez, Wiskirchen, Giamarellou, Pontikis, Parker, Albiero, Lepak, Docobo-Pérez, Grabein, Shields, Temkin, Shields, Shields, Perez, Bulik, Giamarellou, Souli, Oliva, Cprek, Poulakou, Lu, Karvouniaris, Kollef, Rello, Solé-Lleonart, Palmer, Kalil, Monogue, Berthoin, Pea, Lorente, Ho, Kim, Keel, Martínez, Patel, Zarkotou, Falcone, Nguyen, de Oliveira, Dimopoulos, Chastre, Capellier, Havey, Matthaiou, Tacconelli, De Rosa, Sypsa, Gagliotti, Lin, Giacobbe, Munoz-Price, Tofteland, Schwaber, Lerner, De Rosa, Abdallah, Tumbarello, Giannella, Giannella, Giacobbe, Salsano, Sbrana, Girmenia, De Rosa, Forcina, Viale, Zuckerman, Saidel-Odes, Lübbert, Tascini, Oren, Tascini, Machuca, Bassetti, Falagas, Sutcliffe, Connors, Zhang, Solomkin   +142 more
core   +2 more sources

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Development and application of an indirect ELISA and nested PCR for the epidemiological analysis of Klebsiella pneumoniae among pigs in China

Frontiers in Microbiology
IntroductionKlebsiella pneumoniae (K. pneumoniae) is an important opportunistic and zoonotic pathogen which is associated with many diseases in humans and animals. However, the pathogenicity of K.
Zengshuai Wu, Na Li, Ziheng Li, Jianlong Wang, Mengmeng Liu, Mengzhu Qi, Shaopeng Wei, Tong Wu, Yu Guo, Junhui Zhu, Hexiang Jiang, Ruixue Xue, Changjiang Sun, Xin Feng, Jingmin Gu, Wenyu Han, Fengyang Li, Liancheng Lei, Liancheng Lei   +18 more
doaj   +1 more source

Klebsiella variicola Is a Frequent Cause of Bloodstream Infection in the Stockholm Area, and Associated with Higher Mortality Compared to K. pneumoniae

PLoS ONE, 2014
Clinical isolates of Klebsiella pneumoniae are divided into three phylogroups and differ in their virulence factor contents. The aim of this study was to determine an association between phylogroup, virulence factors and mortality following bloodstream ...
M. Maãtallah, M. Vading, M. H. Kabir, A. Bakhrouf, M. Kalin, P. Nauclér, S. Brisse, C. Giske   +7 more
semanticscholar   +1 more source

Increased isolation of ESBL producing Klebsiella pneumoniae with emergence of carbapenem resistant isolates in Pakistan: report from a tertiary care hospital [PDF]

, 2010
OBJECTIVE: To report trends of extended spectrum beta lactamase (ESBL), multidrug resistant (MDR) ESBL and emergence of carbapenem resistant ESBL producing isolates of K. pneumoniae from Pakistan.
Ejaz, Muslima, Hasan, Rumina, Inayat, Raunaq, Jabeen, Kauser, Khan, Erum, Shakoor, Sadia, Zafar, Afia   +6 more
core   +1 more source

Bacteremic community-acquired pneumonia due to Klebsiella pneumoniae: Clinical and microbiological characteristics in Taiwan, 2001-2008 [PDF]

, 2010
Background Klebsiella pneumoniae is the major cause of community-acquired pyogenic infections in Taiwan. This retrospective study evaluated the clinical and microbiological characteristics of bacteremic community-acquired ...
Yi-Tsung Lin, Yuan-Yu Jeng, Te-Li Chen, Chang-Phone Fung   +3 more
core   +1 more source

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

Presence of Polyketide Synthase (PKS) Gene and Counterpart Virulence Determinants in Klebsiella pneumoniae Strains Enhances Colorectal Cancer Progression In-Vitro

Microorganisms, 2023
Klebsiella pneumoniae (K. pneumoniae) colonizes the human gut and is a causative factor of pyogenic liver abscess (PLA). Retrospective studies conducted on K.
Christina Parvinder Kaur, Thevambiga Iyadorai, Cynthia Sears, April Camilla Roslani, Jamuna Vadivelu, Chandramathi Samudi   +5 more
doaj   +1 more source

Characteristics of Meropenem Heteroresistance in Klebsiella pneumoniae Carbapenemase (KPC)-Producing Clinical Isolates of K. pneumoniae [PDF]

Journal of Clinical Microbiology, 2010
ABSTRACT Meropenem heteroresistance was investigated in six apparently meropenem-susceptible, Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) clinical isolates, compared with that in carbapenemase-negative, meropenem-susceptible controls.
Pournaras, S., Kristo, I., Vrioni, G., Ikonomidis, A., Poulou, A., Petropoulou, D., Tsakris, A.   +6 more
openaire   +3 more sources