Results 81 to 90 of about 140,660 (311)

K. pneumoniae ST258 genomic variability and bacteriophage susceptibility [PDF]

, 2019
Abstract Multidrug resistant carbapenemase-producing Klebsiella pneumoniae capable of causing severe disease in humans is classified as an urgent threat by health agencies worldwide.
Venturini, Carola, Zakour, Nouri Ben, Bowring, Bethany, Morales, Sandra, Cole, Robert, Kovach, Zsuzsanna, Branston, Steven, Kettle, Emma, Thomson, Nicholas, Iredell, Jonathan   +9 more
openaire   +1 more source

Determinação fenotípica e genotípica de beta-lactamases de espetro estendido em Escherichia coli, Klebsiella pneumoniae e enterobacter spp. de pacientes internados no Hospital Universitário Professor Polydoro Ernani de São Thiago (HU/UFSC) [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.As enterobactérias são patógenos oportunistas responsáveis por cerca de 70% das infecções urinárias e
Zamparette, Caetana Paes
core  

Phenotypic and genotypic characterization of Klebsiella pneumoniae strains from blood culture samples

, 2023
reservedK. pneumoniae è un importante patogeno opportunista responsabile di circa il 30% delle infezioni causate da batteri Gram-negativi. La diffusione di ceppi resistenti agli antibiotici e/o ipervirulenti ha reso questo batterio una minaccia per il ...
SFERRA, ALICE
core  

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Outer Membrane Vesicles Attenuate Klebsiella pneumoniae Infection Injury by Affecting Macrophage Polarisation and Helper T Cell Differentiation

Microorganisms
Klebsiella pneumoniae (K. pneumoniae) is an opportunistic bacteria that can result in severe liver abscesses, pulmonary damage, and potentially fatal outcomes.
Wei Fan, Wei Wang, Lin Kong, Shifan Chen, Xinyu Zhang, Yilu Zhai, Bo Zhang, Yan Wang, Dazhuo Zhao, Xiukai Tang, Jiaqi Fu, Fuliang Sun   +11 more
doaj   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver

PLoS Pathogens, 2022
Polysaccharide capsule is the main virulence factor of K. pneumoniae, a major pathogen of bloodstream infections in humans. While more than 80 capsular serotypes have been identified in K.
Xueting Huang, Xiuyuan Li, Haoran An, Juanjuan Wang, Ming Ding, Lijun Wang, Lulu Li, Quanjiang Ji, Fen Qu, Hui Wang, Yingchun Xu, Xinxin Lu, Yuan He, Jing-Ren Zhang   +13 more
doaj  

Association of Chlamydia pneumoniae with coronary artery disease and its progression is dependent on the modifying effect of mannose-binding lectin

, 2002
Background— The possible association between coronary artery disease (CAD) and Chlamydia pneumoniae (C pneumoniae) infection is controversial. On the basis of the recent suggestion that mannose-binding lectin (MBL) variant alleles are related to an ...
Karádi, István, Burián, Katalin, Valéria Endrész, Hans O. Madsen, Peter Garred, Jenô Duba, George Füst, Éva Gönczöl, Katalin Burián, Endrész, Valéria, Duba, Jenő, Romics, László, Garred, Peter, Gönczöl, Éva, Prohászka, Zoltán, Füst, György, Rugonfalvi-Kiss, Szabolcs, Szabolcs Rugonfalvi-Kiss, Madsen, Hans O., Zoltán Prohászka, István Karádi, László Romics   +21 more
core   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Prevalence, Virulence, and Pathogenic Mechanisms of Mastitis-Associated Klebsiella pneumoniae in Herds and Phage-Based Control Strategies

Veterinary Sciences
Klebsiella pneumoniae (K. pneumoniae) is an opportunistic and environmental mastitis pathogen prevalent in dairy herds worldwide. Owing to their genetic and genomic diversity, K.
Wenhui Li, Jianwei Wang, Yangsen Wang, Pu Yan, Zhihua Ren, Tong Fu   +5 more
doaj   +1 more source