Results 81 to 90 of about 9,296,418 (261)

jpatirom3/E.-coli-and-K.-pneumoniae-resistance: v0.2-alpha

, 2023
<p>This study employs machine learning and data panel approaches to investigate the widely accepted notion that the consumption of antimicrobials is the primary driver of Escherichia coli and Klebsiella pneumoniae in some European communities.
Jhoana P. Romero-Leiton
core   +1 more source

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing [PDF]

, 2007
Airway infection by the Gram-positive pathogen Streptococcus pneumoniae (Sp) leads to recruitment of neutrophils but limited bacterial killing by these cells.
Adam J Ratner, Thomas B Clarke, Elena S Lysenko, Shchepetov Mikhail, Lysenko, Elena S., Clarke, Thomas B., Dowson, Christopher G., Jeffrey N Weiser, Clarke Thomas B, Christopher G Dowson, Dowson Christopher G, Weiser Jeffrey N, Mikhail Shchepetov, Ratner, Adam J., Shchepetov, Mikhail, Lysenko Elena S, Roper, David I., Weiser, Jeffrey N., David I Roper, Ratner Adam J, Roper David I   +20 more
core   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Genotypes, antibiotic resistance, and virulence diversity among Klebsiella pneumoniae species complex isolates in Taiwan

Gut Pathogens
Background Klebsiella pneumoniae, K. quasipneumoniae, and K. variicola are members of the K. pneumoniae species complex (KpSC) with distinct genotypes, virulence, and antibiotic resistance traits. However, their distribution and characteristics in Taiwan
Chiung-Ju Chen, Chiao-Yu Kao, Ya-Yu Cheng, Rong-Xuan Wu, Yen-Zhen Zhang, Daniel Yeng-Fong Lin, Ming-Cheng Wang, Wei-Hung Lin, Ching-Hao Teng, Hsu-Feng Lu, Yu-Tsung Huang, Pei-Fang Tsai, Ying-Chi Li, Shih-Fen Tseng, Li-Cheng Yen, Cheng-Yen Kao   +15 more
doaj   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

Structural studies on the sialidases from Streptococcus pneumoniae and Pseudomonas aeruginosa [PDF]

, 2009
The sialidases are a group of glycosyl hydrolases that specifically remove terminal sialic acid (Neu5Ac) residues from various glycans. In the two common human pathogenic bacteria Streptococcus pneumoniae and Pseudomonas aeruginosa, these enzymes have
Xu, Guogang
core   +2 more sources

Enhanced invasion and survival of antibiotic- resistant Klebsiella pneumoniae pathotypes in host cells and strain-specific replication in blood

Frontiers in Cellular and Infection Microbiology
BackgroundKlebsiella pneumoniae is one of the most important opportunistic pathogens causing healthcare-associated and community-acquired infections worldwide.
Kathleen Klaper, Kathleen Klaper, Yvonne Pfeifer, Lena Heinrich, Marcel Prax, Oleg Krut, Isabelle Bekeredjian-Ding, Anika Wahl, Martin A. Fischer, Heike Kaspar, Stefan Borgmann, Roman G. Gerlach, Guido Werner   +12 more
doaj   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Overcoming Klebsiella pneumoniae antibiotic resistance: new insights into mechanisms and drug discovery

Beni-Suef University Journal of Basic and Applied Sciences
Background Due to antibiotic overuse, numerous organisms have evolved multidrug resistance, a global health crisis. Klebsiella pneumoniae (K. pneumoniae) causes respiratory, biliary, and urinary infections.
Tran Xuan Ngoc Huy
doaj   +1 more source