Results 101 to 110 of about 11,948,174 (351)

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Angewandte Chemie, EarlyView.
Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham, Edward S. Hems, Daniel C. L. Van, Justin E. Clarke, Sergey Nepogodiev, Julius S. P. Adamson, Christian Bassi, Michael E. Webb, Glyn R. Hemsworth, Orde Q. Munro, Barrie Wilkinson, Ryan F. Seipke   +11 more
wiley   +2 more sources

Supernatant of platelet-Klebsiella pneumoniae coculture induces apoptosis-like death in Klebsiella pneumoniae

Microbiology Spectrum
Multidrug-resistant Klebsiella pneumoniae strains, especially carbapenem-resistant K. pneumoniae, have become a rapidly emerging crisis worldwide, greatly limiting current therapeutic options and posing new challenges to infection management.
Wenting Wang, Yaozhen Chen, Yutong Chen, Erxiong Liu, Jing Li, Ning An, Jinmei Xu, Shunli Gu, Xuan Dang, Jing Yi, Qunxing An, Xingbin Hu, Wen Yin   +12 more
doaj   +1 more source

Critical Issues for Klebsiella Pneumoniae KPC-Carbapenemase Producing K. Pneumoniae Infections: A Critical Agenda

Future Microbiology, 2015
The wide dissemination of carbapenemase producing K. pneumoniae (KPC-Kp) has caused a public health crisis of global dimensions, due to the serious infections in hospitalized patients associated with high mortality. In 2014, we aim to review clinical data on KPC-Kp at a time when a pro-active strategy (combating the problem before it is established) is
DE ROSA, Francesco Giuseppe, CORCIONE, Silvia, CAVALLO, Rossana, DI PERRI, Giovanni, Bassetti M.   +4 more
openaire   +3 more sources

Emergence of an MDR Klebsiella pneumoniae ST231 producing OXA-232 and RmtF in Switzerland [PDF]

, 2017
The increasing incidence of carbapenem-resistant Klebsiella pneumoniae is a major challenge to public health. Despite the fact that the prevalence of carbapenemases among carbapenem-resistant K.
Bassi, Cécile, Lienhard, Reto, Mancini, Stefano, Nordmann, Patrice, Poirel, Laurent, Tritten, Marie-Lise   +5 more
core   +1 more source

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Multivalent Glycopolymer Design Unlocks Antimicrobial Activity of 2‐Deoxyglucose

Angewandte Chemie, EarlyView.
New approaches to combat antimicrobial‐resistant pathogens are needed. Here, scaffolding a nonmetabolizable sugar (2DG) on a polymer backbone is shown to significantly improve its antimicrobial activity. ABSTRACT With the increasing prevalence of multidrug‐resistant (MDR) pathogens, last‐line therapeutics such as cyclic peptides are insufficient ...
Sungjin Jeon, Xianjin Qin, Marjon Zamani, Ariel L. Furst, Cassandra E. Callmann   +4 more
wiley   +2 more sources

Outer Membrane Vesicles Attenuate Klebsiella pneumoniae Infection Injury by Affecting Macrophage Polarisation and Helper T Cell Differentiation

Microorganisms
Klebsiella pneumoniae (K. pneumoniae) is an opportunistic bacteria that can result in severe liver abscesses, pulmonary damage, and potentially fatal outcomes.
Wei Fan, Wei Wang, Lin Kong, Shifan Chen, Xinyu Zhang, Yilu Zhai, Bo Zhang, Yan Wang, Dazhuo Zhao, Xiukai Tang, Jiaqi Fu, Fuliang Sun   +11 more
doaj   +1 more source

Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver

PLoS Pathogens, 2022
Polysaccharide capsule is the main virulence factor of K. pneumoniae, a major pathogen of bloodstream infections in humans. While more than 80 capsular serotypes have been identified in K.
Xueting Huang, Xiuyuan Li, Haoran An, Juanjuan Wang, Ming Ding, Lijun Wang, Lulu Li, Quanjiang Ji, Fen Qu, Hui Wang, Yingchun Xu, Xinxin Lu, Yuan He, Jing-Ren Zhang   +13 more
doaj  

Genome Sequence of a Klebsiella pneumoniae Sequence Type 258 Isolate with Prophage-Encoded K. pneumoniae Carbapenemase [PDF]

Genome Announcements, 2015
ABSTRACT We present the draft genome sequence of a Klebsiella pneumoniae carbapenemase (KPC)-producing sequence type 258 (ST258) K. pneumoniae strain, ST258_FL. Uniquely, strain ST258_FL harbors two copies of the bla KPC gene on the chromosome ...
Chen, Liang, Chavda, Kalyan D., DeLeo, Frank R., Bryant, Kendall A., Jacobs, Michael R., Bonomo, Robert A., Kreiswirth, Barry N.   +6 more
openaire   +2 more sources