Results 71 to 80 of about 140,660 (311)

Convergence of carbapenem resistance and hypervirulence leads to high mortality in patients with postoperative Klebsiella pneumoniae meningitis

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The aims of this study were to investigate the characteristics of Klebsiella pneumoniae meningitis and the impact of convergence of carbapenem resistance and hypervirulence on patient mortality.Methods: Antimicrobial resistance and ...
Yuming Li, Dakang Hu, Xiaobo Ma, Dan Li, Dongxing Tian, Ye Gong, Xiaofei Jiang   +6 more
doaj   +1 more source

Fingolimod synergizes and reverses K. pneumoniae resistance to colistin

Frontiers in Microbiology
Klebsiella pneumoniae (K. pneumoniae) infection and the rapid spread of multi-drug resistant (MDR) bacteria pose a serious threat to global healthcare. Polymyxin E (colistin), a group of cationic antimicrobial polypeptides, is currently one of the last resort treatment options against carbapenem-resistant Gram-negative pathogens.
Xiang Geng, Zhen-Dong Zhang, Yu-Xi Li, Ruo-Chen Hao, Ya-Jun Yang, Xi-Wang Liu, Jian-Yong Li   +6 more
openaire   +3 more sources

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Supernatant of platelet-Klebsiella pneumoniae coculture induces apoptosis-like death in Klebsiella pneumoniae

Microbiology Spectrum
Multidrug-resistant Klebsiella pneumoniae strains, especially carbapenem-resistant K. pneumoniae, have become a rapidly emerging crisis worldwide, greatly limiting current therapeutic options and posing new challenges to infection management.
Wenting Wang, Yaozhen Chen, Yutong Chen, Erxiong Liu, Jing Li, Ning An, Jinmei Xu, Shunli Gu, Xuan Dang, Jing Yi, Qunxing An, Xingbin Hu, Wen Yin   +12 more
doaj   +1 more source

Presence of Polyketide Synthase (PKS) Gene and Counterpart Virulence Determinants in Klebsiella pneumoniae Strains Enhances Colorectal Cancer Progression In-Vitro

Microorganisms, 2023
Klebsiella pneumoniae (K. pneumoniae) colonizes the human gut and is a causative factor of pyogenic liver abscess (PLA). Retrospective studies conducted on K.
Christina Parvinder Kaur, Thevambiga Iyadorai, Cynthia Sears, April Camilla Roslani, Jamuna Vadivelu, Chandramathi Samudi   +5 more
doaj   +1 more source

Genomic Epidemiology of an Endoscope-Associated Outbreak of Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae

PLOS ONE, 2015
Increased incidence of infections due to Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) was noted among patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) at a single hospital. An epidemiologic investigation identified KPC-Kp and non-KPC-producing, extended-spectrum β-lactamase (ESBL)-producing
Marsh, JW, Krauland, MG, Nelson, JS, Schlackman, JL, Brooks, AM, Pasculle, AW, Shutt, KA, Doi, Y, Querry, AM, Muto, CA, Harrison, LH   +10 more
openaire   +4 more sources

Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone [PDF]

, 2011
We report on the comparative genomics and characterization of the virulence phenotypes of four <i>S. pneumoniae</i> strains that belong to the multidrug resistant clone PMEN1 (Spain^23F ST81).
Longwell Mark J., Mitchell, T.J., Dawid, S., Sá-Leão, Raquel, Tomasz, Alexander, Dahlgren Margaret E., Earl Joshua P., N Luisa Hiller, Ehrlich Garth D., Hillman, Todd A, Powell, E., Martin, D.P., Hu, F.Z., Tettelin Herve, Hu Fen Z., Hiller N. Luisa, Ehrlich, G.D., Sá-Leão, R., Tettelin, H., Azad Ahmed, Buchinsky, Farrel J, Dahlgren, Margaret E, Ehrlich, Garth D, Daugherty, S.C., Mitchell Timothy J., Timothy J Mitchell, Farrel J Buchinsky, Tomasz Alexander, Margaret E Dahlgren, Ezzo, S., Hiller, N.L., Eutsey, R.A., Powell, Evan, Martin Darren P., Ezzo, Suzanne, Post, J.C., Hiller, N Luisa, Longwell, Mark J, Benjamin Janto, Buchinsky, F.J., Evan Powell, Herve Tettelin, Garth D Ehrlich, de Lencastre Herminia, Dahlgren, M.E., Dawid, Suzanne, Rory A Eutsey, Daugherty Sean C., Tettelin, Herve, Daugherty, Sean C, Eutsey, Rory A, Alexander Tomasz, Fen Z Hu, Sá-Leão Raquel, Herminia de Lencastre, J Christopher Post, Dawid Suzanne, Post, J Christopher, Suzanne Dawid, Mark J Longwell, Powell Evan, Mitchell, Timothy J, Ahmed, Azad, Post J. Christopher, Joshua P Earl, Hillman Todd A., de Lencastre, H., Janto, Benjamin, Todd A Hillman, Janto Benjamin, Ezzo Suzanne, Earl, Joshua P, Tse, H., Raquel Sá-Leão, Eutsey Rory A., Darren P Martin, Buchinsky Farrel J., de Lencastre, Herminia, Ahmed, A., Suzanne Ezzo, Earl, J.P., Hu, Fen Z, Janto, B., Ahmed Azad, Sean C Daugherty, Martin, Darren P, Hillman, T.A., Longwell, M.J., Tomasz, A.   +88 more
core   +1 more source

Klebsiella pneumoniae in the marine environment [PDF]

, 2023
Klebsiella pneumoniae is an opportunistic pathogen present in a wide range of environments. This species is often associated with antibiotic resistance and is a leading cause of health care associated infections but can also cause community acquired ...
Håkonsholm, Fredrik
core   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

High prevalence of Klebsiella pneumoniae carbapenemase-mediated resistance in K. pneumoniae isolates from Egypt

Eastern Mediterranean Health Journal, 2013
The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. This study in a tertiary care hospital in Egypt used real-time PCR assay to test ertapenem-nonsusceptible isolates of K.
L, Metwally, N, Gomaa, M, Attallah, N, Kamel   +3 more
openaire   +2 more sources