Results 51 to 60 of about 9,296,418 (261)

Pneumonia bacteriana adquirida na comunidade: avaliação clínico-epidemiológica e padronização de métodos moleculares para detecção de Mycoplasma pneumoniae, Haemophilus influenzae e Streptococcus pneumoniae [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.A pneumonia pode ser causada por diversos microrganismos e classificada de forma abrangente, havendo ...
Machado, Lais Del Prá Netto
core  

Seasonality and outbreak of a predominant Streptococcus pneumoniae serotype 1 clone from The Gambia: expansion of ST217 hypervirulent clonal complex in West Africa. [PDF]

, 2008
BACKGROUND: Streptococcus pneumoniae serotype 1 causes > 20% of invasive disease, among all age groups combined, in The Gambia. In contrast, it is rarely detected in carriage studies. This study compares the molecular epidemiology of S.
Greenwood, Brian M, Martin Antonio, Uzochukwu Egere, Egere Uzochukwu, Akisanya, Abiodun, Sankareh Kawsu, George Lahai, Kawsu Sankareh, Timothy Awine, Nsekpong, David, Lahai George, Hakeem Ishrat, Zaman, Syed MA, Hill Philip C, Syed MA Zaman, Awine, Timothy, Egere, Uzochukwu, Secka, Ousman, Sankareh, Kawsu, Awine Timothy, Richard A Adegbola, Godwin Enwere, Ousman Secka, Philip C Hill, Felicity Cutts, Akisanya Abiodun, Nsekpong David, Lahai, George, Cutts Felicity, Secka Ousman, Hakeem, Ishrat, Cutts, Felicity, Antonio Martin, Enwere Godwin, Tumani Corrah, Corrah, Tumani, Adegbola Richard A, Hill, Philip C, Brian M Greenwood, Adegbola, Richard A, David Nsekpong, Corrah Tumani, Enwere, Godwin, Zaman Syed MA, Greenwood Brian M, Antonio, Martin, Ishrat Hakeem, Abiodun Akisanya   +47 more
core   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Supernatant of platelet-Klebsiella pneumoniae coculture induces apoptosis-like death in Klebsiella pneumoniae

Microbiology Spectrum
Multidrug-resistant Klebsiella pneumoniae strains, especially carbapenem-resistant K. pneumoniae, have become a rapidly emerging crisis worldwide, greatly limiting current therapeutic options and posing new challenges to infection management.
Wenting Wang, Yaozhen Chen, Yutong Chen, Erxiong Liu, Jing Li, Ning An, Jinmei Xu, Shunli Gu, Xuan Dang, Jing Yi, Qunxing An, Xingbin Hu, Wen Yin   +12 more
doaj   +1 more source

Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone [PDF]

, 2011
We report on the comparative genomics and characterization of the virulence phenotypes of four <i>S. pneumoniae</i> strains that belong to the multidrug resistant clone PMEN1 (Spain^23F ST81).
Longwell Mark J., Mitchell, T.J., Dawid, S., Sá-Leão, Raquel, Tomasz, Alexander, Dahlgren Margaret E., Earl Joshua P., N Luisa Hiller, Ehrlich Garth D., Hillman, Todd A, Powell, E., Martin, D.P., Hu, F.Z., Tettelin Herve, Hu Fen Z., Hiller N. Luisa, Ehrlich, G.D., Sá-Leão, R., Tettelin, H., Azad Ahmed, Buchinsky, Farrel J, Dahlgren, Margaret E, Ehrlich, Garth D, Daugherty, S.C., Mitchell Timothy J., Timothy J Mitchell, Farrel J Buchinsky, Tomasz Alexander, Margaret E Dahlgren, Ezzo, S., Hiller, N.L., Eutsey, R.A., Powell, Evan, Martin Darren P., Ezzo, Suzanne, Post, J.C., Hiller, N Luisa, Longwell, Mark J, Benjamin Janto, Buchinsky, F.J., Evan Powell, Herve Tettelin, Garth D Ehrlich, de Lencastre Herminia, Dahlgren, M.E., Dawid, Suzanne, Rory A Eutsey, Daugherty Sean C., Tettelin, Herve, Daugherty, Sean C, Eutsey, Rory A, Alexander Tomasz, Fen Z Hu, Sá-Leão Raquel, Herminia de Lencastre, J Christopher Post, Dawid Suzanne, Post, J Christopher, Suzanne Dawid, Mark J Longwell, Powell Evan, Mitchell, Timothy J, Ahmed, Azad, Post J. Christopher, Joshua P Earl, Hillman Todd A., de Lencastre, H., Janto, Benjamin, Todd A Hillman, Janto Benjamin, Ezzo Suzanne, Earl, Joshua P, Tse, H., Raquel Sá-Leão, Eutsey Rory A., Darren P Martin, Buchinsky Farrel J., de Lencastre, Herminia, Ahmed, A., Suzanne Ezzo, Earl, J.P., Hu, Fen Z, Janto, B., Ahmed Azad, Sean C Daugherty, Martin, Darren P, Hillman, T.A., Longwell, M.J., Tomasz, A.   +88 more
core   +2 more sources

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

The role of the Streptococcus pneumoniae capsule in interactions with complement and phagocytes [PDF]

, 2010
The Streptococcus pneumoniae capsule is an essential virulence factor and it is ideally situated to modulate interactions between the bacteria and host immune cells.
Hyams, C.J.
core  

Characterization of novel beta-galactosidase activity that contributes to glycoprotein degradation and virulence in Streptococcus pneumoniae.

, 2010
The pneumococcus obtains its energy from the metabolism of host glycosides. Therefore, efficient degradation of host glycoproteins is integral to pneumococcal virulence.
Andrew, Peter W, Homer, Karen A, Yesilkaya, Hasan, Terra, Vanessa S, Rao, Susmitha G   +4 more
core   +1 more source

Pneumococcal Gene Complex Involved in Resistance to Extracellular Oxidative Stress [PDF]

, 2012
Streptococcus pneumoniae is a Gram-positive bacterium which is a member of the normal human nasopharyngeal flora but can also cause serious disease such as pneumonia, bacteremia, and meningitis. Throughout its life cycle, S.
Cecilia A. Hinojosa, Jong, Anne de,, de Jong, Anne; id_orcid, Jetta J. E. Bijlsma, Anne de Jong, Kuipers, Oscar P.; id_orcid, Kuipers, Oscar P., Oscar P. Kuipers, de Jong, Anne, Orihuela, Carlos J.,, Farshchi Andisi, Vahid,, Bijlsma, Jetta J.E.,, Hinojosa, Cecilia A.,, Vahid Farshchi Andisi, Kuipers, Oscar P.,, Carlos J. Orihuela, Farshchi Andisi, Vahid, Bijlsma, Jetta J. E., Hinojosa, Cecilia A., Orihuela, Carlos J.   +19 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source