Results 41 to 50 of about 140,660 (311)

Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics?

Frontiers in Cellular and Infection Microbiology, 2022
Klebsiella pneumoniae (K. pneumoniae) is a typical gram-negative iatrogenic bacterium that often causes bacteremia, pneumonia and urinary tract infection particularly among those with low immunity.
Zihan Liang, Zihan Liang, Zihan Liang, Yiyao Wang, Yiyao Wang, Yiyao Wang, Yixiang Lai, Yixiang Lai, Yixiang Lai, Jingyi Zhang, Jingyi Zhang, Jingyi Zhang, Lanlan Yin, Lanlan Yin, Lanlan Yin, Xiang Yu, Xiang Yu, Xiang Yu, Yongqin Zhou, Yongqin Zhou, Yongqin Zhou, Xinzhi Li, Xinzhi Li, Yinhong Song, Yinhong Song, Yinhong Song   +25 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo [PDF]

, 2012
Lipoproteins are an important class of surface associated proteins that have diverse roles and frequently are involved in the virulence of bacterial pathogens.
Hermans Peter W. M., Brown, J.S., Durmort Claire, Jeremy S. Brown, Jonathan M Cohen, Emilie Camberlein, Hermans, P.W.M., Camberlein Emilie, Durmort, C, Vernet Thierry, MacDonald, N, Chimalapati, S, Claire Durmort, Jeremy S Brown, Timothy Mitchell, Suneeta Chimalapati, Cohen, J.M., Camberlein, E, Peter W. M. Hermans, Brown, JS, Chimalapati, S., Hermans, PWM, Vernet, T., Chimalapati Suneeta, Camberlein, E., Mitchell, T., Mitchell Timothy, MacDonald, N., Peter W M Hermans, Nathanael MacDonald, Thierry Vernet, Vernet, T, Cohen, JM, Cohen Jonathan M., Brown Jeremy S., MacDonald Nathanael, Durmort, C., Jonathan M. Cohen, Mitchell, T   +38 more
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Aspiration pneumonia in association with oral vitamin K [PDF]

Archives of Disease in Childhood - Fetal and Neonatal Edition, 2002
Most infants born in the British Isles now receive vitamin K prophylaxis, and the trend towards oral administration continues.1 With the awareness that vitamin K is well absorbed from the gut2 and following publication of the report linking intramuscular vitamin K and childhood cancer,3 oral vitamin K prophylaxis has become more widespread.
openaire   +1 more source

Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase–producing K. pneumoniae [PDF]

Clinical Microbiology and Infection, 2016
The aim of this study was to identify factors associated with mortality in intensive care unit patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) septic shock. A retrospective analysis of intensive care unit patients with KPC-Kp infection and septic shock observed in a large teaching hospital from November 2010 to ...
FALCONE, MARCO, RUSSO, ALESSANDRO, Iacovelli, Alessandra, Restuccia, G., CECCARELLI, GIANCARLO, GIORDANO, Alessandra, FARCOMENI, Alessio, MORELLI, Andrea, VENDITTI, Mario   +8 more
openaire   +4 more sources

Genome analysis of a highly virulent serotype 1 strain of streptococcus pneumoniae from West Africa [PDF]

, 2012
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and bacteremia, estimated to cause 2 million deaths annually. The majority of pneumococcal mortality occurs in developing countries, with serotype 1 a leading cause in these areas.
Loman Nicholas J., Martin Antonio, Nicholas J Loman, Tiffany M. Williams (126277), Richard A. Adegbola (20657), Pallen, Mark J., Tiffany M. Williams, Weinstock, George M, Mark J. Pallen, Williams, Tiffany M., Loman, Nicholas J., Weinstock, George M., Martin Antonio (42317), Musher, Daniel M., George M. Weinstock, Musher Daniel M., Richard A. Adegbola, Adegbola, Richard A., Richard A Adegbola, Mark J Pallen, George M Weinstock, Daniel M. Musher, Loman, Nicholas J, Nicholas J. Loman (126279), Ebruke Chinelo, Pallen, Mark J, Weinstock George M., Tiffany M Williams, Antonio Martin, Williams, Tiffany M, Ebruke, Chinelo, Daniel M Musher, Mark J. Pallen (8904), Williams Tiffany M., Adegbola Richard A., Pallen Mark J., George M. Weinstock (43281), Daniel M. Musher (126285), Adegbola, Richard A, Chinelo Ebruke (126282), Musher, Daniel M, Antonio, Martin, Nicholas J. Loman, Chinelo Ebruke   +43 more
core   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Clinical Observation and Prognostic Analysis of Patients With Klebsiella pneumoniae Bloodstream Infection

Frontiers in Cellular and Infection Microbiology, 2020
Background and purposeThe clinical prognosis of Klebsiella pneumoniae(K. pneumoniae) bloodstream infection is poor, and the prevalence of drug-resistant bacteria makes clinical anti-infective treatment more challenging. This retrospective study evaluated
Shuguang Zhang, Ziyue Yang, Limin Sun, Zhenhua Wang, Liutao Sun, Liutao Sun, Jinli Xu, Jinli Xu, Li Zeng, Tongwen Sun   +9 more
doaj   +1 more source

Genome Sequence of a Klebsiella pneumoniae Sequence Type 258 Isolate with Prophage-Encoded K. pneumoniae Carbapenemase [PDF]

Genome Announcements, 2015
ABSTRACT We present the draft genome sequence of a Klebsiella pneumoniae carbapenemase (KPC)-producing sequence type 258 (ST258) K. pneumoniae strain, ST258_FL. Uniquely, strain ST258_FL harbors two copies of the bla KPC gene on the chromosome ...
Chen, Liang, Chavda, Kalyan D., DeLeo, Frank R., Bryant, Kendall A., Jacobs, Michael R., Bonomo, Robert A., Kreiswirth, Barry N.   +6 more
openaire   +2 more sources