Results 61 to 70 of about 9,296,418 (261)

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Outer Membrane Vesicles Attenuate Klebsiella pneumoniae Infection Injury by Affecting Macrophage Polarisation and Helper T Cell Differentiation

Microorganisms
Klebsiella pneumoniae (K. pneumoniae) is an opportunistic bacteria that can result in severe liver abscesses, pulmonary damage, and potentially fatal outcomes.
Wei Fan, Wei Wang, Lin Kong, Shifan Chen, Xinyu Zhang, Yilu Zhai, Bo Zhang, Yan Wang, Dazhuo Zhao, Xiukai Tang, Jiaqi Fu, Fuliang Sun   +11 more
doaj   +1 more source

Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver

PLoS Pathogens, 2022
Polysaccharide capsule is the main virulence factor of K. pneumoniae, a major pathogen of bloodstream infections in humans. While more than 80 capsular serotypes have been identified in K.
Xueting Huang, Xiuyuan Li, Haoran An, Juanjuan Wang, Ming Ding, Lijun Wang, Lulu Li, Quanjiang Ji, Fen Qu, Hui Wang, Yingchun Xu, Xinxin Lu, Yuan He, Jing-Ren Zhang   +13 more
doaj  

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Mycoplasma Pneumoniae infections in the Maltese Islands [PDF]

, 2000
Mycoplasma pneumoniae is a free living micro-organism which is classified in the family Mycoplasmataceae. It is primarily a human respiratory pathogen and the infection may vary from a mild pharyngitis to a pneumonia. M. pneumoniae infections are usually
Portelli, Alfred V., Barbara, Christopher   +1 more
core  

The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae.

, 2008
Streptococcus pneumoniae colonizes the mucin-rich environment of the nasopharynx. As colonization may be the first stage of infection, investigation was carried out as to whether the pneumococcus could utilize mucin as a source of nutrient and whether ...
Manco, Sonia, Kadioglu, Aras, Andrew, Peter W, Yesilkaya, Hasan, Terra, Vanessa S   +4 more
core   +1 more source

Antibiotic sensitivity screening of Klebsiella spp. and Raoultella spp. isolated from marine bivalve molluscs reveal presence of CTX-M-producing K. pneumoniae [PDF]

, 2020
Klebsiella spp. are a major cause of both nosocomial and community acquired infections, with K. pneumoniae being responsible for most human infections. Although Klebsiella spp.
Marit A. K. Hetland, Hetland, Marit A.K., Fredrik Håkonsholm, Bjørn Tore Lunestad, Nachiket P. Marathe, Marathe, Nachiket, Lunestad, Bjørn Tore, Cecilie S. Svanevik, Svanevik, Cecilie Smith, Sundsfjord, Arnfinn, Arnfinn Sundsfjord, Håkonsholm, Fredrik   +11 more
core   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Whole-Genome Sequencing of Human Clinical Klebsiella pneumoniae Isolates Reveals Misidentification and Misunderstandings of Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae

mSphere, 2017
Klebsiella pneumoniae is a major threat to public health, causing significant morbidity and mortality worldwide. The emergence of highly drug-resistant strains is particularly concerning. There has been a recognition and division of Klebsiella pneumoniae
S. Wesley Long, Sarah E. Linson, Matthew Ojeda Saavedra, Concepcion Cantu, James J. Davis, Thomas Brettin, Randall J. Olsen   +6 more
doaj   +1 more source