Results 91 to 100 of about 40,339 (186)

Characterization of K562 cells: uncovering novel chromosomes, assessing transferrin receptor expression, and probing pharmacological therapies. [PDF]

Cell Mol Life Sci, 2023
Karagiannis TC, Wall M, Ververis K, Pitsillou E, Tortorella SM, Wood PA, Rafehi H, Khurana I, Maxwell SS, Hung A, Vongsvivut J, El-Osta A.   +11 more
europepmc   +1 more source

Bioactive Phytochemical Compounds in Medicago sativa L. (Alfalfa): A Systematic Review of Biological Properties and Therapeutic Relevance in Nutraceutical and Functional Food Implications

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani, Hamid Rashidi Nodeh, Zahra Esfandiari, Giovanna Ferrentino   +3 more
wiley   +1 more source

Smenospongine, a Sesquiterpene Aminoquinone from a Marine Sponge, Induces G1 Arrest or Apoptosis in Different Leukemia Cells

Marine Drugs, 2008
Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells.
Motomasa Kobayashi, Toshiyuki Sakai, Yoshihiro Sowa, Shunji Aoki, Dexin Kong   +4 more
doaj  

Induction of the Erythroid Differentiation of K562 Cells Is Coupled with Changes in the Inter-Chromosomal Contacts of rDNA Clusters. [PDF]

Int J Mol Sci, 2023
Tchurikov NA, Klushevskaya ES, Alembekov IR, Kretova AN, Chechetkin VR, Kravatskaya GI, Kravatsky YV.   +6 more
europepmc   +1 more source

Pigmented Sorghum Phenolic Extracts Regulate the Expression of Cancer Development Pathway Genes in HT‐29 and Hypoxia‐Induced CCD 841 CoN Cells

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
A depiction of reconstituted red sorghum and black sorghum extract effects on HT‐29 and CCD 841 CoN cell cells at 500 and 2000 μg/mL for 12 and 24 h resulting in the decrease of cancer cell viability, modulation of mutation‐associated genes, and suppression of hypoxia and metabolic signaling.
Aduba Collins, Kenneth Chinkwo, Nidhish Francis, Abishek Bommannan Santhakumar, Christopher Blanchard   +4 more
wiley   +1 more source

Study of leukemic stem cell population (CD34+/CD38-) and WT1 protein expression in human leukemic cell lines

Journal of Associated Medical Sciences, 2018
Background: Leukemic stem cells (LSCs) play a central role in relapse and refractory cases of leukemia patients. This cell has been found to resist to a conventional chemotherapy more than leukemic cells.
Pawaret Panyajai, Noppadet Amnajphook, Sommawan Keawsangthongcharoen, Sawitree Chiampanichayakul, Singkome Tima, Songyot Anuchapreeda   +5 more
doaj  

Cerium oxide nanoparticles-assisted aptasensor for chronic myeloid leukaemia detection

ADMET and DMPK
Background and purpose: Chronic myeloid leukaemia (CML) is one of the most lethal types of leukaemia and can rapidly progress if not treated properly. Therefore, having an effective diagnostic strategy is crucial.
Yuspian Nur, Yeni Wahyuni Hartati, Muhammad Ihda HL Zein, Irkham Irkham, Shabarni Gaffar, Toto Subroto   +5 more
doaj   +1 more source

Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells. [PDF]

J Enzyme Inhib Med Chem, 2023
Zhang G, Tang Z, Fan S, Li C, Li Y, Liu W, Long X, Zhang W, Zhang Y, Li Z, Wang Z, Chen D, Ouyang G.   +12 more
europepmc   +1 more source

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source

CD4‐Based Chimeric Antigen Receptor (CAR)‐T Cells With Resistance to HIV‐1 Infection and Enhanced Anti‐HIV Efficacy: Covalent Interaction Between CD4‐CAR and HIV‐1 Envelope Glycoprotein

Journal of Medical Virology, Volume 98, Issue 3, March 2026.
ABSTRACT The current highly active antiretroviral therapy (HAART or ART) effectively suppresses de novo HIV‐1 infection but fails to eliminate HIV reservoir cells, which leads to rapid viral rebound upon ART cessation. Chimeric antigen receptor (CAR) T cells engineered to target HIV‐1 Env⁺ cells offer a promising strategy to eliminate or control these ...
Yaoxian Lou, Xiuting He, Guangming Li, Martin Sikhondze, Jianping Ma, Hongwei Du, Xin Ouyang, Gianpietro Dotti, Mohammad Sajadi, Lishan Su   +9 more
wiley   +1 more source