Results 161 to 170 of about 40,339 (186)

Mechanism of Simvastatin-Induced K562 Cell Apoptosis

Pharmacology, 2009
Statins are being widely used for the therapy and prevention of several types of tumors, including human chronic myelogenous leukemia, but the underlying molecular mechanisms still remain unknown. Therefore, inhibition of cell proliferation, apoptosis and involved molecules were investigated in K562 cells after incubation with simvastatin.The results ...
Yong-Chang, Yang, Dai-Wen, Xiao, Hua, Liu, Liang-Min, Chuan, Ya-Li, Zeng, Ding-An, Zhou, Wen, Liu, Guo-Qiang, Xu, Wen-Fang, Huang   +8 more
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Variation amongst K562 cell cultures.

Experimental hematology, 1983
K562 cell cultures were obtained from three laboratories (A, B and C) outside our institution, and were designated according to source as K562A, K562B or K562C. The cultures obtained were constitutive or "wild type" K562 cell cultures, not cloned sublines.
I W, Dimery, D D, Ross, J R, Testa, S K, Gupta, R L, Felsted, A, Pollak, N R, Bachur   +6 more
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BCL11A represses HBG transcription in K562 cells

Blood Cells, Molecules, and Diseases, 2009
BCL11A on chromosome 2p16 was recently shown to be a major quantitative trait locus for Hb F level and F-cell number in several populations with or without beta-hemoglobinopathy. We now show that BCL11A isoforms are expressed in K562 cells. Butyrate induction of HBG globin production in K562 is associated with reduced BCL11A.
Zhiyi, Chen, Hong-yuan, Luo, Martin H, Steinberg, David H K, Chui   +3 more
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Geldanamycin Induces Cell Cycle Arrest in K562 Erythroleukemic Cells

IUBMB Life, 1999
AbstractGeldanamycin (GA), a benzoquinone ansamycin, is one of the specific inhibitors of 90‐kDa heat shock protein and induces growth inhibition and apoptosis in certain cancer cell lines. We have investigated the mechanism of GA‐induced growth inhibition in K562 erythroleukemic cells.
H R, Kim, C H, Lee, Y H, Choi, H S, Kang, H D, Kim   +4 more
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Stromal cell-dependent terminal maturation of K562 erythroleukaemia cells

Leukemia Research, 1991
K562 cells were cultured over monolayers of various cell types for four days and the characteristics of those cells which became firmly adherent to such monolayers studied. The monolayers used were composed of stromal cells derived from human bone marrow, two human fibroblast lines, human umbilical cord-derived endothelial cells, bone marrow ...
S R, Zuhrie, S N, Wickramasinghe
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Apoptosis inducing effect of meisoindigo on K562 cells

Chinese Journal of Integrated Traditional and Western Medicine, 1999
To study the effect of meisoindigo on human chronic myelogenous leukemia (CML) cell line K562 cells for exploring the mechanism of meisoindigo in treatment of CML.Multiple methods, including dose-response curve, trypan blue exclusion, cytomorphology, DNA electrophoresis, flow cytometry and TUNEL (TdT mediated dUTP nick and labeling), were used to ...
L, Song, L, Qian
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Expression profile of Notch‐related genes in multidrug resistant K562/A02 cells compared with parental K562 cells

International Journal of Laboratory Hematology, 2010
SummaryDrug resistance is the major setback of acute myeloid leukemia (AML) therapy. Notch proteins have demonstrated functional regulation in cell proliferation, differentiation, and apoptosis and thus may affect drug resistance. Our study aimed to identify the Notch‐related gene profile in drug‐resistant AML cells and provide potential strategies for
S, Yan, D, Ma, M, Ji, D, Guo, J, Dai, P, Zhao, C, Ji   +6 more
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Effects of inducers of erythroid differentiation of human leukemia K562 cells on vincristine-resistant K562/VCR cells

Leukemia Research, 1983
K562/VCR cells, which are resistant to the cytotoxicity of vincristine, were isolated from human erythroleukemia K562 cells. Various compounds that induce erythroid differentiation of K562 cells were tested on K562/VCR cells. Differentiation of K562/VCR cells was not induced by actinomycin D or adriamycin alone, but the resistance of these cells to the
J, Okabe-Kado, M, Hayashi, Y, Honma, M, Hozumi, T, Tsuruo   +4 more
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Expression of C antigen in transduced K562 cells

Transfusion, 2001
BACKGROUND: The Rh blood group system is involved in HDN and transfusion reactions. A retrovirus‐expression system was previously used to show that polypeptides carrying the Rh blood group antigens are encoded by the RHD and RHCE genes. This study investigated the structure of the C antigen.STUDY DESIGN AND METHODS: K562 cells were transduced with full‐
J S, Smythe, D J, Anstee
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c-Jun binding site identification in K562 cells

Journal of Genetics and Genomics, 2011
Determining the binding sites of the transcription factor is important for understanding of transcriptional regulation. Transcription factor c-Jun plays an important role in cell growth, differentiation and development, but the binding sites and the target genes are not clearly defined in the whole human genome.
Minli, Li, Qinyu, Ge, Wei, Wang, Jinke, Wang, Zuhong, Lu   +4 more
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