Results 11 to 20 of about 40,339 (186)
High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription. [PDF]
PLoS ONE, 2013 We examined the antileukemic effects of high concentrations of L-ascorbic acid (high AA) on human leukemic cells. In vitro, high AA markedly induced apoptosis in various leukemic cell lines by generating hydrogen peroxide (H2O2) but not in normal ...
Hiroshi Kawada +7 more
doaj +1 more source
Pinellia pedatisecta agglutinin targets drug resistant K562/ADR leukemia cells through binding with sarcolemmal membrane associated protein and enhancing macrophage phagocytosis. [PDF]
PLoS ONE, 2013 Pinelliapedatisecta agglutinin (PPA) has previously been used in labeling fractions of myeloid leukemia cells in our laboratory. We report here that a bacterial expressed recombinant PPA domain b tagged with soluble coxsackie and adenovirus receptor ...
Kan Chen +7 more
doaj +1 more source
Journal of Pharmacological Sciences, 2013 Multiple drug resistance (MDR) occurring during chemotherapy is a major obstacle for treatment of cancers using chemotherapeutic drugs; thus, the mechanisms underlying MDR have attracted intensive attention.
Hong Xin +7 more
doaj +1 more source
Cells, 2020 Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment.
Jui-Hung Yen +5 more
doaj +1 more source
CFTR in K562 human leukemic cells
American Journal of Physiology-Cell Physiology, 2003 In this study, the expression and functional characterization of CFTR (cystic fibrosis transmembrane regulator) was determined in K562 chronic human leukemia cells. Expression of the CFTR gene product was determined by RT-PCR and confirmed by immunohistochemistry and Western blot analysis.
Assef, Yanina Andrea +4 more
openaire +3 more sources
Journal of Experimental & Clinical Cancer Research, 2009 Objective A novel multi-drug resistance gene named as HA117 has been screened and cloned in multidrug resisitant leukemia cell lines in our previous research, but its function is still unknown.
Liu Xiaomei +7 more
doaj +1 more source
HERG1 Currents in Native K562 Leukemic Cells
Journal of Membrane Biology, 2007 The human ether-a-go-go related gene (HERG1) K+ channel is expressed in neoplastic cells, in which it was proposed to play a role in proliferation, differentiation and/or apoptosis. K562 cells (a chronic myeloid leukemic human cell line) express both the full-length (herg1a) and the N-terminally truncated (herg1b) isoforms of the gene, and this was ...
Cavarra, Maria Soledad +4 more
openaire +3 more sources
Journal of Experimental & Clinical Cancer Research, 2009 Background The regulation of growth and apoptosis in K562 cells by human bone marrow mesenchymal stem cells (MSCs) from leukemia patients was investigated. Methods K562 cells were cocultured with leukemic MSCs under serum deprivation. Cell Counting Kit-8
Liu Bin +9 more
doaj +1 more source
In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells [PDF]
International Journal of Biological Sciences, 2016 Chronic myelogenous leukemia (CML) is a malignant hematological disorder mainly caused by the Bcr-Abl tyrosine kinase. While Bcr-Abl inhibitors including Imatinib showed antitumor efficacy on many CML patients, resistance was frequently reported in recent years. Therefore, novel drugs for CML are still expected.
Zhou, Qianxiang +8 more
openaire +2 more sources
Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy [PDF]
Toxicology Mechanisms and Methods, 2012 Arsenic trioxide (As(2)O(3)) has been reported to have potent antitumor effects in vitro and in vivo by inducing cell death via cell cycle arrest and apoptosis in leukemia cells, but the mechanisms of As(2)O(3)-mediated cell death are not fully understood.
Juan, Cheng +3 more
openaire +2 more sources