Results 21 to 30 of about 40,339 (186)

Assesment Of The Efficacy Of HESA-A On The Proliferation And Apoptosis Of Chronic Myelogenous Leukemia Cell Line(K562) [PDF]

پیاورد سلامت, 2012
Background and Aim: Chronic myelogenous leukemia is characterized by Philadelphia (Ph) chromosome, the presence of BCR-ABL fusion gene and constitutive activation of the ABL1 tyrosine kinase.
Mahdihe Ghasemi, Fatemeh Nadali, Seyed Naser Ostad, Farhad Zaker, Shahrbanoo Rostamy, Hossein Dargahi   +5 more
doaj   +1 more source

Differences of basic and induced autophagic activity between K562 and K562/ADM cells

Intractable & Rare Diseases Research, 2017
Patients with acute myeloid leukemia (AML) often have a poor prognosis due to drug resistance, which is regarded as a tough problem during the period of clinical therapeutics. It has been reported that autophagy, an important event in various cellular processes, plays a crucial role in mediating drug-resistance to cancer cells.
Feifei, Wang, Jing, Chen, Zhewen, Zhang, Juan, Yi, Minmin, Yuan, Mingyan, Wang, Na, Zhang, Xuemin, Qiu, Hulai, Wei, Ling, Wang   +9 more
openaire   +3 more sources

Calcitonin receptor gene expression in K562 chronic myelogenous leukemic cells

Cancer Cell International, 2003
Background The peptide hormone calcitonin (CT) can significantly effect the proliferation rate of CT receptor (CTR) positive human cancer cells. We wish to identify additional human cancers expressing CTRs and assay the effects of CT on their growth ...
Pondel Marc D, Mould Richard
doaj   +1 more source

Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines

Saudi Pharmaceutical Journal, 2021
Background: Phytoestrogens are polyphenolic plant compounds which are structurally similar to the endogenous mammalian estrogen, 17β-estradiol. Annexin A1 (ANXA1) is an endogenous protein which inhibits cyclo-oxygenase 2 (COX-2) and phospholipase A2 ...
Affidah Sabran, Endang Kumolosasi, Ibrahim Jantan, Jamia Azdina Jamal, Norazrina Azmi, Malina Jasamai   +5 more
doaj   +1 more source

Comparative proteomic analysis of differentially expressed proteins between K562 and K562/ADM cells

Chinese Medical Journal, 2008
Multidrug resistance to chemotherapeutic agents is an important clinical problem during the treatment of leukemia. The resistance process is multifactorial. To realize the total factors involved in multidrug resistance, we analyzed the differentially expressed proteins of K562 and K562/ADM cells and we investigated one of the up-regulated proteins ...
Shao-hua, Shen, Long-jun, Gu, Pei-qing, Liu, Xin, Ye, Wei-shan, Chang, Ben-shang, Li   +5 more
openaire   +2 more sources

Acylphosphatase is involved in differentiation of K562 cells [PDF]

Cell Death & Differentiation, 1997
The level of both isoforms of acylphosphatase was evaluated in the human erythroleukemia K562 cell line during differentiation. K562 cells were treated with PMA, which induces megakaryocytic differentiation, and with aphidicolin or hemin, which stimulate erythrocytic differentiation. While the MT isoform showed an average 10-fold increase independently
CHIARUGI, PAOLA, DEGL'INNOCENTI, DONATELLA, TADDEI, MARIA LETIZIA, RAUGEI, GIOVANNI, BERTI, ANDREA, RIGACCI, STEFANIA, RAMPONI, GIAMPIETRO   +6 more
openaire   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Lycorine attenuated proliferation and induced apoptosis on imatinib-resistant K562 cell by inhibiting autophagy

Discover Oncology
Background Tyrosine kinase inhibitor (TKI) resistance is a significant factor exacerbating the burden on chronic myeloid leukemia (CML) patients and impacting clinical efficacy.
Jun Bai, Zuxi Feng, Yaqiong Chen, Yanhong Li, Liansheng Zhang, Lijuan Li   +5 more
doaj   +1 more source

Specific globin mRNAs in human erythroleukemia (K562) cells [PDF]

Blood, 1984
Abstract Specific globin mRNA accumulation was quantitated in several lines of K562 cells in the absence and the presence of hemin. Using specific cloned DNA probes, the amounts of zeta, alpha, epsilon and gamma mRNAs were shown to be increased 2–3-fold in the presence of 20 microM hemin. No delta- or beta-globin mRNAs were detectable in
C W, Miller, K, Young, D, Dumenil, B P, Alter, J M, Schofield, A, Bank   +5 more
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source