Results 61 to 70 of about 40,339 (186)
Retrovirology, 2004 Background Dendritic cell (DC) transmission of human immunodeficiency virus (HIV) to CD4+ T cells occurs across a point of cell-cell contact referred to as the infectious synapse.
Breun Sabine KJ +4 more
doaj +1 more source
Sitravatinib enhances doxorubicin cytotoxicity in doxorubicin‐resistant K562/ADM cells
Bulletin of the Korean Chemical Society, EarlyView.A repositioning‐based screening identified sitravatinib that synergistically enhances doxorubicin efficacy in doxorubicin‐resistant leukemia cells. Abstract Drug resistance remains a major obstacle in leukemia treatment, and combination therapy has emerged as an effective strategy to overcome this limitation. This study aimed to identify compounds with
Min Jeong Ahn +3 more
wiley +1 more source
PLoS ONE, 2012 High mobility group box 1 (HMGB1) protein is released from cells as a pro-inflammatory cytokine in response to an injury or infection. During dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), a number of pro-inflammatory cytokines are released,
Siew Pei Ong +4 more
doaj +1 more source
Dynamics of natural killer cell function upon recurrent stimulation
Biotechnology Progress, EarlyView.Weekly stimulation of peripheral blood‐derived NK cells with engineered K562 feeder cells resulted in two distinct growth phases, shifting around Day 21–26. Cells in growth phase 2 exhibited slower growth, reduced metabolic activity, and lower cytotoxicity than cells from growth phase 1, which has implications for NK cell biomanufacturing.
Jennifer One +4 more
wiley +1 more source
HematologyBackground Imatinib (IM) is the primary treatment for patients with chronic-phase CML (CML-CP). However, an increasing number of CML-CP patients have developed resistance to IM.
Yaqin Jiang +8 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel +5 more
wiley +1 more source
Effect of interaction of magnetic nanoparticles of Fe3O4 and artesunate on apoptosis of K562 cells
International Journal of Nanomedicine, 2011 Ying Wang1, Yuxiang Han1, Yingying Yang1, Jingci Yang1, Xiaonan Guo1, Jingnan Zhang1, Ling Pan1, Guohua Xia2, Baoan Chen21Department of Hematology, the 2nd Hospital of Hebei Medical University, People’s Republic of China; 2Department of ...
Wang Y +8 more
doaj
Frontiers in Oncology, 2020 The cell-microenvironment communication is essential for homing of hematopoietic stem cells in stromal niches. Recent evidences support the involvement of epithelial-to-mesenchymal (EMT) process in hematopoietic stem cell homeostasis as well as in ...
Roberta Chirillo +14 more
doaj +1 more source
WT1 regulates cyclin�A1 expression in K562�cells
Oncology Reports, 2019 The restricted expression of Wilms tumor 1 (WT1) and cyclin A1 (CCNA1) in normal tissues, as opposed to their abnormal expression in leukemia demonstrates the applicability of WT1 and CCNA1 as cancer antigens for immunotherapy, and as markers for prognosis and relapse.
Sony, Pandey +4 more
openaire +3 more sources
Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security
Journal of the Science of Food and Agriculture, EarlyView.Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori +9 more
wiley +1 more source