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Inhibitors of AMPA and Kainate Receptors
Current Medicinal Chemistry, 2001The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
U, Madsen +2 more
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Kainate receptors and synaptic transmission
Progress in Neurobiology, 2003Excitatory glutamatergic transmission involves a variety of different receptor types, each with distinct properties and functions. Physiological studies have identified both post- and presynaptic roles for kainate receptors, which are a subtype of the ionotropic glutamate receptors.
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Kainate receptor pharmacology and physiology
Cellular and Molecular Life Sciences (CMLS), 1999Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have resulted in the emergence of several selective agonists and antagonists.
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Kainate receptors: subunits, synaptic localization and function
Trends in Pharmacological Sciences, 1999Vernon Clarke +2 more
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