Structural insights into kainate receptor desensitization [PDF]
Nature CommunicationsKainate receptors (KARs) belong to the ionotropic glutamate receptor (iGluR) family and play critical roles in mediating excitatory neurotransmission and regulating neurotransmitter release.
Changping Zhou +2 more
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Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor [PDF]
Cell Reports, 2016 Synaptic communication between neurons requires the precise localization of neurotransmitter receptors to the correct synapse type. Kainate-type glutamate receptors restrict synaptic localization that is determined by the afferent presynaptic connection.
Christoph Straub +10 more
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Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]
PLoS ONE, 2014 Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chao-Yin Chen +3 more
doaj +20 more sources
Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity [PDF]
Cell Reports, 2017 Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans +4 more
doaj +2 more sources
GluK2 kainate receptor subunit-selective, potentiating RNA aptamer [PDF]
Scientific ReportsKainate receptors are a subtype of ionotropic glutamate receptors. Potent and selective modulatory agents of kainate receptors are potential drug candidates for treatment of various neurological diseases involving receptor dysregulation.
Samantha R. Ingenito +3 more
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Coordinated interplay between palmitoylation, phosphorylation and SUMOylation regulates kainate receptor surface expression [PDF]
Front Mol Neurosci, 2023 Yucel BP +5 more
europepmc +6 more sources
Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice [PDF]
Cell Reports, 2017 Kainate receptors are members of the glutamate receptor family that regulate synaptic function in the brain. They modulate synaptic transmission and the excitability of neurons; however, their contributions to neural circuits that underlie behavior are ...
Jian Xu +10 more
doaj +2 more sources
The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines. [PDF]
Front Cell Neurosci, 2020 Kesaf S +9 more
europepmc +2 more sources
Functional implications of the exon 9 splice insert in GluK1 kainate receptors
eLifeKainate receptors are key modulators of synaptic transmission and plasticity in the central nervous system. Different kainate receptor isoforms with distinct spatiotemporal expressions have been identified in the brain.
Surbhi Dhingra +3 more
doaj +2 more sources
Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors
Membranes, 2021 Kainate receptors are members of the ionotropic glutamate receptor family. They form cation-specific transmembrane channels upon binding glutamate that desensitize in the continued presence of agonists.
Cuauhtemoc U. Gonzalez +3 more
doaj +1 more source