Assembly Stoichiometry of the GluK2/GluK5 Kainate Receptor Complex
Cell Reports, 2012 Ionotropic glutamate receptors assemble as homo- or heterotetramers. One well-studied heteromeric complex is formed by the kainate receptor subunits GluK2 and GluK5.
Andreas Reiner +2 more
doaj +1 more source
AMPA Receptors in NG2 Glia Differently Affect Signal Transduction in the Hippocampus and Cerebellum
Glia, Volume 74, Issue 2, February 2026.Stronger expression of Ca2+ permeable AMPA receptors in cerebellar versus hippocampal NG2 glia. Different expression patterns of glial AMPA receptors and auxiliary subunits in both regions. Higher efficacy of neuron‐NG2 glia synapses in the cerebellum.
Dario Tascio +5 more
wiley +1 more source
Oral Supplementation With a Bovine Thymus Extract Reduces Neuronal Excitability in Aging Mice
FASEB BioAdvances, Volume 8, Issue 2, February 2026.Oral supplementation of aging mice with a nuclear fraction extract of bovine thymus (TNF) leads to significant increases in GAD65, GAD67, and β2/β3 subunits of the GABAA receptor, more so with high dose (HD) TNF treatment compared to low dose (LD) and control condition.
Abdeslem El‐Idrissi +2 more
wiley +1 more source
Neuroprotection by urokinase plasminogen activator in the hippocampus
Neurobiology of Disease, 2012 Tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which are both used for thrombolytic treatment of acute ischemic stroke, are serine proteases that convert plasminogen to active plasmin. Although recent experimental evidences
Eunsil Cho +9 more
doaj +1 more source
Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus [PDF]
, 2003 Several neurotransmitters, including GABA acting at presynaptic GABAB receptors, modulate glutamate release at synapses between hippocampal mossy fibers and CA3 pyramidal neurons.
Bowery, N.G. +5 more
core
Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition [PDF]
, 2015 The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a
Cao, Hong +4 more
core +2 more sources
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Immune checkpoint regulators can improve neurological functions in Alzheimer's disease. However, it remains blurred whether these regulators may ameliorate temporal lobe epilepsy (TLE) and TLE‐related cognitive impairment. This study analyzed the bulk transcriptomic data of human TLE hippocampi by bioinformatics.
Man Li +3 more
wiley +1 more source
Decreased numerical density of kainate receptor-positive neurons in the orbitofrontal cortex of chronic schizophrenics [PDF]
, 2018 We utilised postmortem brain tissue to quantify sections of left and right orbitofrontal cortex (area 11) from nine schizophrenic and eight control patients from the Charing Cross Prospective Schizophrenia Study immunostained for the presence of the ...
Garey, L. +2 more
core
Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]
, 1993 Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer +60 more
core +1 more source
Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey
Hippocampus, Volume 36, Issue 1, January 2026.ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley +1 more source