Results 41 to 50 of about 5,024,889 (297)
GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats [PDF]
, 1991 We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in ...
DiMicco, Joseph A., Soltis, Robert P.
core +2 more sources
Biological and Pharmaceutical Bulletin, 2018 Echinacoside is a major compound of Cistanche Herb and has glutamate release-inhibiting activity in the brain. Given the involvement of excitotoxicity caused by massive glutamate in the pathophysiology of epilepsy, we explored the antiepileptic effect of
Cheng-Wei Lu +5 more
semanticscholar +1 more source
Aminooxadiazolyl kainic acid reveals that kainic acid receptors contribute to astrocytoma glutamate signaling [PDF]
, 2021 ABSTRACTThe excitatory neurotransmitter glutamate triggers a Ca2+rise and the extension of processes in astrocytes. Our results suggest that kainic acid receptors (KAR) can independently initiate glutamate signaling in astrocytoma U118-MG cells. The natural product kainic acid triggered glioexcitablity in cells and was inhibited by the KAR antagonist ...
Mitra Sadat Tabatabaee +3 more
openaire +2 more sources
Biotechnology & Biotechnological Equipment, 2017 Epilepsy is one of most reported neurological disorders after migraine, stroke and Alzheimer's disease. Empiric clinical data reveal that seizures and epilepsy more likely affect men than women.
Slavina Surcheva +4 more
doaj +1 more source
Ceramide is a Mediator of Apoptosis in Retina Photoreceptors [PDF]
, 2006 PURPOSE. The precise mechanisms involved in photoreceptor apoptosis are still unclear. We here investigated the role of ceramide, a sphingolipid precursor that induces apoptosis upon cellular stress, in activating this death in photoreceptors.
Abrahan, Carolina Elizabeth +3 more
core +1 more source
Scientific Reports, 2016 Currently, no reliable markers are available to evaluate the epileptogenic potential of a brain injury. The electroencephalogram is the standard method of diagnosis of epilepsy; however, it is not used to predict the risk of developing epilepsy ...
Svenja Heischmann +6 more
semanticscholar +1 more source
Frontiers in Neurology, 2017 The aim of epilepsy models is to investigate disease ontogenesis and therapeutic interventions in a consistent and prospective manner. The kainic acid-induced status epilepticus (KASE) rat model is a widely used, well-validated model for temporal lobe ...
Daniele Bertoglio +6 more
semanticscholar +1 more source
Molecular Mechanism Involved in the Pathogenesis of Early-Onset Epileptic Encephalopathy [PDF]
, 2019 Recent studies have shown that neurologic inflammation may both precipitate and sustain seizures, suggesting that inflammation may be involved not only in epileptogenesis but also in determining the drug-resistant profile.
Corsello G +5 more
core +1 more source
Everolimus is better than rapamycin in attenuating neuroinflammation in kainic acid-induced seizures
Journal of Neuroinflammation, 2017 BackgroundMicroglia is responsible for neuroinflammation, which may aggravate brain injury in diseases like epilepsy. Mammalian target of rapamycin (mTOR) kinase is related to microglial activation with subsequent neuroinflammation. In the present study,
Ming-Tao Yang +4 more
semanticscholar +1 more source
Nonictal EEG biomarkers for diagnosis and treatment. [PDF]
, 2018 There are no reliable nonictal biomarkers for epilepsy, electroencephalography (EEG) or otherwise, but efforts to identify biomarkers that would predict the development of epilepsy after a potential epileptogenic insult, diagnose the existence of ...
Bragin, Anatol +2 more
core +2 more sources