Results 71 to 80 of about 5,024,889 (297)
Gut‐microbiota‐brain Axis and post‐traumatic epilepsy
Epilepsia Open, EarlyView.Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley +1 more source
Frontiers in Neuroscience, 2016 We report the methodology for the chronic delivery of an excitotoxin to the mouse spinal cord via surgically implanted osmotic mini-pumps. Previous studies have investigated the effect of chronic application of excitotoxins in the rat, however there has ...
Catherine A Blizzard +2 more
doaj +1 more source
Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice
Scientific Reports, 2021 MicroRNAs are short non-coding RNAs that negatively regulate protein levels and perform important roles in establishing and maintaining neuronal network function.
Aoife Campbell +9 more
doaj +1 more source
A Literature Review On Intermittent Fasting [PDF]
, 2020 Intermittent fasting has been instructed in the Bible as an implied part of daily living. This paper has reviewed the physical benefits of intermittent fasting. In healthy test subjects, it has led to higher levels of autophagy, gut health, and lifespan.
Carrero, Kylie
core +1 more source
Absence seizures: Update on signaling mechanisms and networks
Epilepsia Open, EarlyView.Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley +1 more source
Differential conserted activity induced regulation of Nogo receptors (1-3), LOTUS and Nogo mRNA in mouse brain. [PDF]
PLoS ONE, 2013 Nogo Receptor 1 (NgR1) mRNA is downregulated in hippocampal and cortical regions by increased neuronal activity such as a kainic acid challenge or by exposing rats to running wheels.
Tobias E Karlsson +4 more
doaj +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
Acacetin Inhibits Glutamate Release and Prevents Kainic Acid-Induced Neurotoxicity in Rats
PLoS ONE, 2014 An excessive release of glutamate is considered to be a molecular mechanism associated with several neurological diseases that causes neuronal damage. Therefore, searching for compounds that reduce glutamate neurotoxicity is necessary. In this study, the
Tzu-Yu Lin +4 more
semanticscholar +1 more source
Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures [PDF]
, 2015 Hippocampal neurogenesis is changed by brain injury. When neuroinflammation accompanies injury, activation of resident microglial cells promotes the release of inflammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO).
Araújo, Inês +4 more
core +4 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra +3 more
wiley +1 more source