Results 81 to 90 of about 15,508 (221)

The Effect of long-term rapamycin administration on intracellular calcium quantification and RhoA activity in kainic acid epilepsy model [PDF]

Brazilian Journal of Pharmaceutical Sciences
Epilepsy affects around 50 million people worldwide, with 30% of them being refractory epilepsy. This shows that there is still a need for novel anti-seizure medication that have different mechanisms.
Machlusil Husna, Kusworini Handono, Hidayat Sujuti, Aulanni’am Aulanni’am, Rumman Karimah, Afiyfah Kiysa Waafi, Alya Satira   +6 more
doaj   +1 more source

In vivo measurement of hippocampal GABAA/cBZR density with [18F]-flumazenil PET for the study of disease progression in an animal model of temporal lobe epilepsy.

PLoS ONE, 2014
PurposeImbalance of inhibitory GABAergic neurotransmission has been proposed to play a role in the pathogenesis of temporal lobe epilepsy (TLE). This study aimed to investigate whether [(18)F]-flumazenil ([(18)F]-FMZ) PET could be used to non-invasively ...
Lucy Vivash, Marie-Claude Gregoire, Viviane Bouilleret, Alexis Berard, Catriona Wimberley, David Binns, Peter Roselt, Andrew Katsifis, Damian E Myers, Rodney J Hicks, Terence J O'Brien, Stefanie Dedeurwaerdere   +11 more
doaj   +1 more source

The effects of glycemic control on seizures and seizure-induced excitotoxic cell death

BMC Neuroscience, 2012
Background Epilepsy is the most common neurological disorder after stroke, affecting more than 50 million persons worldwide. Metabolic disturbances are often associated with epileptic seizures, but the pathogenesis of this relationship is poorly ...
Schauwecker Paula
doaj   +1 more source

Simultaneous BOLD fMRI and local field potential measurements during kainic acid–induced seizures [PDF]

, 2012
Antti M. Airaksinen, S. K. Hekmatyar, Neil P. Jerome, Juha‐Pekka Niskanen, J. Huttunen, Asla Pitkänen, Risto A. Kauppinen, Olli Gröhn   +7 more
openalex   +1 more source

Outer hair cells stir cochlear fluids

eLife
We hypothesized that active outer hair cells drive cochlear fluid circulation. The hypothesis was tested by delivering the neurotoxin, kainic acid, to the intact round window of young gerbil cochleae while monitoring auditory responses in the cochlear ...
Choongheon Lee, Mohammad Shokrian, Kenneth S Henry, Laurel H Carney, J Christopher Holt, Jong-Hoon Nam   +5 more
doaj   +1 more source

A short review on toxin-induced animal models of Huntington’s disease

Chronic Diseases Journal
BACKGROUND: Huntington's disease (HD) is a hereditary neurodegenerative motor and cognitive disorder. Different animal models of HD have been provided to study the different aspects of the disease, such as pathophysiology and treatment, and also the cure.
Ahmad Fotoohi
doaj   +1 more source

Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats [PDF]

, 2022
Manana Kandashvili, Georgi Gamkrelidze, Lia Tsverava, Tamar Lordkipanidze, Eka Lepsveridze, Vincenzo Lagani, M. Burjanadze, M. Dashniani, Mérab Kokaia, Revaz Solomonia   +9 more
openalex   +1 more source

REGULATION OF X CHROMOSOME-LINKED INHIBITOR OF APOPTOSIS PROTEIN (XIAP) IN KAINIC ACID INDUCED NEURONAL CELL DEATH IN THE RAT HIPPOCAMPUS

, 2001
Laura Korhonen, Natale Belluardo, Dan Lindholm   +2 more
openalex   +1 more source

Synergistic neuroprotective action of prolactin and 17β-estradiol on kainic acid-induced hippocampal injury and long-term memory deficit in ovariectomized rats. [PDF]

, 2023
Karen De la Torre, Marco Cerbón, Gladys Molina-Salinas, José Eduardo Suárez-Santiago, Jean Pascal Morin, Gabriel Roldán-Roldán, Ofir Picazo   +6 more
openalex   +1 more source

A Formal Synthesis of (–)-Kainic Acid by Means of SmI2-Mediated Radical Cyclization

, 2018
Kazunori Takahashi, Takumi Ito, Wataru Yamada, Masayoshi Tsubuki, Toshio Honda   +4 more
openalex   +1 more source